DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	534	Identity:	138/534 - (25%)
Similarity:	248/534 - (46%)	Gaps:	75/534 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYK 68
            :|....::..::.|:.::..|...::||.|||..:..||||:  ::...|....:||    |..|
Zfish     7 LSVTWTLVVLVITLLLIYGVWPHGFFKKLGIPGPRPLPFVGT--ALSYSKGICNFDI----ECSK 65

  Fly    69 NTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDF-------RSFHDNEMAKFTDSKTDPILANNPFV 126
            ....:.|::..|:|.|:||..|....|.|.|.       |:.:.:.:..|.|..|         :
Zfish    66 KYGKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNPDLVGPFADGIT---------L 121

  Fly   127 LTGEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEV 191
            :..|.|:..|:.::|..::.|:|..:|:::....:|::.:.::.   |...|..||:...|:.:|
Zfish   122 VKDERWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKD---PNLPLKIKDVVAPYSLDV 183

  Fly   192 ISDCVLGISAQSFTDNPTPMVGMTKRVFEQS------FGFIFYTVVANLWPPITKFYSVSLFAKD 250
            ::.....:...|..:...|.|...|..|..:      ....|....|||   :.|. .:|:|::.
Zfish   184 VASSSFSVDFDSINNPDDPFVTSIKSFFNINPLSPLFLLLAFCPSAANL---LAKM-GISVFSRS 244

  Fly   251 VAAFFYDLMQKCIQVRRESPAAQQRDDFLNYMLQ-------------LQEKKGLNAAELTSHTMT 302
            ...|:|..::|   ::.|...:..|.|||..|:|             .|..|||...|:.|.:..
Zfish   245 TTDFYYKALRK---IKDEHNESNGRVDFLKLMIQNQIPDDQVKDTASEQPVKGLTDHEILSQSFI 306

  Fly   303 FLTDGFETTAQVLTHTLLFLARNPKEQMKLREEIG-----TAELTFEQISELPFTEACIHETLRI 362
            |:..|:|||:..|::.|..||.||....||.|||.     ...:|::.:..:.:.|..|||::|:
Zfish   307 FILGGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLDIPITYDALMRMDYLEMAIHESMRV 371

  Fly   363 FSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVI-IPVNALHHDPQYYEEPQSFKPERFLNINGG 426
            |.......:|..:..|:   ||:::   |.:.:: ||:..|..||..:|.|..||||||   :..
Zfish   372 FPAGPRLERVCKKTVEI---NGITI---PKNTLVGIPLYVLSRDPDLWESPNEFKPERF---SPE 427

  Fly   427 AKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEID---DTYFMP 488
            :|...:|..|..||.|||.|.||||:|..:|..:|::::.:.:    :|.|:.:|.   :.:|.|
Zfish   428 SKTEINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTV----ETCKETQIPVQLNFFFQP 488

  Fly   489 ALKGGVWLDFVERN 502
              |..:.|..:.|:
Zfish   489 --KVPITLKLIPRS 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	124/473 (26%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	130/497 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910