Protein Alignment Cyp28d1 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_608912.1
• Gene: Cyp28d1 / 33749
• FlyBaseID: FBgn0031689
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 139/539 - (25%)
• Similarity: 232/539 - (43%)
• Gaps: 77/539 - (14%)

  Fly     5 STALFVIAA--ILALIYVFLTWNFSYWKKRGIPT-AKSWPFVGSFPSVFTQKRNVVYDIDEIYEQ 66
            ::||.:..|  :|:|:....::...:.:.|.||| |:::|.||....:....|.....|.|..|:
Human    19 ASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEE 83

  Fly    67 YKNTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEA 131
            |::. .::.::...:|.:.:...|....|..|. :....:.|.||    .:|.|.......||..
Human    84 YRHM-PLLKLWVGPVPMVALYNAENVEVILTSS-KQIDKSSMYKF----LEPWLGLGLLTSTGNK 142

  Fly   132 WKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDL----------CLC 186
            |:.||..:||           .....:.:.|::.:..|:      .:..|.|          |..
Human   143 WRSRRKMLTP-----------TFHFTILEDFLDIMNEQA------NILVKKLEKHINQEAFNCFF 190

  Fly   187 YTT----EVISDCVLG--ISAQSFTDNPTPMVGMTKRVFEQSFGFI---------FYTVVANLWP 236
            |.|    ::|.:..:|  |.|||..|  :..|....|:.|..|..|         :|.:....|.
Human   191 YITLCALDIICETAMGKNIGAQSNDD--SEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWE 253

  Fly   237 PITKFYSVSLFAKDVAAFFYDLM---QKCI-QVRRESPAAQQRDDFLNYMLQLQEKKG--LNAAE 295
            .......:..|...|.|...:.|   :.|. ..|..:|:..:|..||:.:|.:.:.:|  |:..:
Human   254 HKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHED 318

  Fly   296 LTSHTMTFLTDGFETTAQVLTHTLLFLARNPKEQMKLREEI----GTAE--LTFEQISELPFTEA 354
            :.....||:.:|.:|||..:..:|..|..||:.|.|:..|:    |.::  .|.|.:.:|.:.|.
Human   319 IREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLEC 383

  Fly   355 CIHETLRIFSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPER 419
            .|.||||:|..|....:.|:|.||:.   |..| |:..:.||||. |||.||:|:..|:.|:|||
Human   384 VIKETLRLFPSVPLFARSVSEDCEVA---GYRV-LKGTEAVIIPY-ALHRDPRYFPNPEEFQPER 443

  Fly   420 FLNING-GAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDD 483
            |...|. |...|    .:..|..|||.|.|.:|::.:.|..|..|:|:|.|:.|.|..:......
Human   444 FFPENAQGRHPY----AYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQ 504

  Fly   484 TYFMPALKGGVWLDFVERN 502
            ....|:  .|:|:....||
Human   505 LILRPS--NGIWIKLKRRN 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	CYP6-like	69..495	CDD:410679	118/463 (25%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	122/474 (26%)