DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	144/485 - (29%)
Similarity:	241/485 - (49%)	Gaps:	43/485 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74
            ::|.||.|:|...|.....:||:|||..|..||:|:..:.:  |....:|:    |.||....|.
  Rat    14 LLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYY--KGLGRFDM----ECYKKYGKIW 72

  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKERRAEV 139
            |:|..:.|...:...|....:.|.:..|...|.    .|.....|:.....|...|.||..||.:
  Rat    73 GLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNR----RDFGPVGIMGKAVSVAKDEEWKRYRALL 133

  Fly   140 TPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGISAQSF 204
            :|..::.|:|..:|:..:.....|:|:::::  ...:.:..|.:...|:.:||:....|::..|.
  Rat   134 SPTFTSGRLKEMFPIIEQYGDILVKYLKQEA--ETGKPVTMKKVFGAYSMDVITSTSFGVNVDSL 196

  Fly   205 TDNPTPMVGMTKRVFEQSFGF---IFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLMQKCI 263
            .:...|.|..||::..  |.|   :|.:||  |:|   ||.:..::.:|.||..|||...:.:..
  Rat   197 NNPKDPFVEKTKKLLR--FDFFDPLFLSVV--LFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIK 257

  Fly   264 QVRRESPAAQQRDDFLNYMLQLQEK-------KGLNAAELTSHTMTFLTDGFETTAQVLTHTLLF 321
            :.|.:| ..:.|.|||..||.....       |.|:..|:.:.::.|:..|:|||:..|:..|.|
  Rat   258 ETRLDS-KHKHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQSVIFIFAGYETTSSTLSFVLYF 321

  Fly   322 LARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELTN 381
            ||.:|..|.||:|||     ..|..|::.:.|:.:.:..::||||::.......:|..:..||
  Rat   322 LATHPDIQKKLQEEIDGALPSKAPPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIEL-- 384

  Fly   382 KNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRIC 446
             :|:.:.  .|.||.||..|||||||::.:|:.|.||||...|.|:   .|..::..||:|||.|
  Rat   385 -DGLFIP--KGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGS---IDPYVYLPFGNGPRNC 443

  Fly   447 PGMRFSLTQIKAALVEIVRNFDIKVNPKTR 476
            .||||:|..:|.||.::::||..:...:|:
  Rat   444 IGMRFALMNMKLALTKVLQNFSFQPCKETQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	134/460 (29%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	124/426 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920