DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp28d1 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	140/517 - (27%)
Similarity:	245/517 - (47%)	Gaps:	57/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74
            ::|..|.|.|::.|::...:||.|||..|..|..|   ::|.....:....|:.|::|   ..|.
  Rat    14 LLATSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFG---TIFNYGDGMWKFDDDCYKKY---GKIW 72

  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNE--------MAKFTDSKTDPILANNPFVLTGEA 131
            |.::...|.|.:..||....:.|.:..|...|.        |.|......|            |.
  Rat    73 GFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPMGFMKKAITMSED------------EE 125

  Fly   132 WKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCV 196
            ||..|..::|..::.::|..:|:..:.....::.:||:.  |..:.:|.||:...|:.:||:...
  Rat   126 WKRLRTILSPTFTSGKLKEMFPLMRQYGDTLLKNLRREE--AKGEPINMKDIFGAYSMDVITGTS 188

  Fly   197 LGISAQSFTDNPTPMVGMTKRVFE-QSFGFIFYTVVANLWPPITKFYSV---SLFAKDVAAFFYD 257
            .|::..|..:...|.|...|::.: |.|.....:||  |:|.:|..|.:   |:|.:....||..
  Rat   189 FGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVV--LFPFLTPIYEMLNFSIFPRQSMNFFKK 251

  Fly   258 LMQKCIQVRRESPAAQQRDDFLNYMLQLQEKKG------LNAAELTSHTMTFLTDGFETTAQVLT 316
            .: |.::..|.....:.|.|||..|:..|..||      |:..|:.:..:.|:..|::.|:..::
  Rat   252 FV-KTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAIIFIFGGYDATSTSIS 315

  Fly   317 HTLLFLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEP 376
            ..:..||..|..|.||:.||     ..|.:|::.:.|:.:.:..::|:||::.......:|..:.
  Rat   316 FIMYELATRPNVQKKLQNEIDRALPNKAPVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKD 380

  Fly   377 CELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGD 441
            .|:   |||.:.  .|.||.||:..||.:|:|:.||:.|.||||...|.|:   .|..::..||:
  Rat   381 VEI---NGVFIP--KGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKENKGS---IDPYVYLPFGN 437

  Fly   442 GPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEID-DTYFMPALKGGVWLDFVERN 502
            |||.|.||||:|..:|.|::.:::||:|:...||:...:|. ...|.|  :|.:.|..|.|:
  Rat   438 GPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQPIFQP--EGPIILKLVSRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	124/464 (27%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	121/454 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820