DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and cyp-13B2

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_510369.2	Gene:	cyp-13B2 / 187068	WormBaseID:	WBGene00010606	Length:	511	Species:	Caenorhabditis elegans

Alignment Length:	517	Identity:	127/517 - (24%)
Similarity:	226/517 - (43%)	Gaps:	83/517 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDE--------IYEQY 67
            :.||:.::..:..|..||||:|||......||:|||           ||:.:        |.:..
Worm     7 LVAIIGVVAGYFKWIHSYWKRRGIEGPVGLPFIGSF-----------YDLADREKPRGFIINKWT 60

  Fly    68 KNTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTD-----SKTDPILANNPFVL 127
            |....:.|.::..||.|:|:..:...::::..|..|:..:......     |:.:|.:  |.|..
Worm    61 KMFGKVFGYYEGVIPVLVVSDLDMLQEMFIKKFDCFYARKTTNLIHGNLECSQEEPRV--NLFAA 123

  Fly   128 TGEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVI 192
            .|..||..||..:|..|...:|..:..........|:::.:|   ...:..|..:....:|.:||
Worm   124 RGARWKRLRALASPAFSVKALKQIHETMEDSVFSMVDHMSKQ---VNGEAFNIHEYYQEFTYDVI 185

  Fly   193 SDCVLGISAQSFTDN-PTPMVGMTKRVFEQSFGFIFYTVVANLWPPI------TKFYSVSLFAKD 250
            |...:|   |::::. ....|.:.|::|.:. ..::...:|.::|..      |.|...::...|
Worm   186 SRLAMG---QTYSEQFNNEGVDIVKKIFLRK-NRVYPWYLAVMFPGFENTIKNTFFNHEAVRGGD 246

  Fly   251 VAAFF-------YD-LMQKCIQVRR--ESPAAQQRDDFLNYMLQ---------LQEKKGLNAAEL 296
            |....       :| |.::...|.:  |:|.....|.||:|...         ::.:|.:.:.::
Worm   247 VGKLLKFCETAVHDRLKERADNVEQGIENPHNDFIDMFLDYYTDTNIEDNAFGIKVEKKVTSEDV 311

  Fly   297 TSHTMTFLTDGFETTAQVLTHTLLFLARNPKEQMKLREEIG---TAE-LTFEQISELPFTEACIH 357
            ......||..||:|||..|.:....||::|:|..|:::||.   |:| ::::.|.:|.:.:|.|.
Worm   312 IGACFVFLLAGFDTTANTLAYASYLLAKHPQEMRKVQDEIDRICTSEHISYDDIGKLRYMDAVIR 376

  Fly   358 ETLRIFSPV--LAARKVVTEPCELTN---KNGVSVKLRPGDVVIIPVNALHHDPQYY-EEPQSFK 416
            |.||:: ||  .|..:...:...|.|   :.||.::        ..|.|||:..:.: :....|.
Worm   377 EALRMY-PVAWFACSRECVQATTLGNYYIEKGVRIE--------ADVRALHYSEEIWGKNANEFV 432

  Fly   417 PERFLNINGGAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKD 478
            |||:|.     ...|....:..||.|||.|.|||..|::.|.||..::|.|.|...|||.|:
Worm   433 PERWLE-----SSPRHNMSWIPFGAGPRQCVGMRLGLSEAKTALAHLLRRFSILAGPKTEKE 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	116/490 (24%)
cyp-13B2	NP_510369.2	p450	32..490	CDD:278495	117/492 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820