DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp3a9

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_671739.2	Gene:	Cyp3a9 / 171352	RGDID:	708392	Length:	503	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	142/490 - (28%)
Similarity:	246/490 - (50%)	Gaps:	52/490 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDS 72
            |.||:  |.|:|::.|.:...:||.|||..|..||:|:..:.    |...::.|:..  :|....
  Rat    14 LLVIS--LVLLYLYGTHSHGIFKKLGIPGPKPLPFLGTILAY----RKGFWEFDKYC--HKKYGK 70

  Fly    73 IVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKT-DP--ILANNPFVLTGEAWKE 134
            :.|::..|.|.|.:|.|:....:.|.:..|       .||:.:. .|  ||.....:...|.||.
  Rat    71 LWGLYDGRQPVLAITDPDIIKTVLVKECYS-------TFTNRRNFGPVGILKKAISISEDEEWKR 128

  Fly   135 RRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGI 199
            .||.::|..::.::|..:|:..:.....|..:|:.|  ...:..:.||:...|:.:||:....|:
  Rat   129 IRALLSPTFTSGKLKEMFPIINQYTDMLVRNMRQGS--EEGKPTSMKDIFGAYSMDVITATSFGV 191

  Fly   200 SAQSFTDNPTPMVGMTKRVFE-QSFGFIFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLMQ 260
            :..|..:...|.|...|::.: ..|..:|.:|  .|:|   |:.:..:||:|.:||..||...::
  Rat   192 NVDSLNNPQDPFVEKIKKLLKFDIFDPLFLSV--TLFPFLTPLFEALNVSMFPRDVIDFFKTSVE 254

  Fly   261 KCIQVRRESPAAQQRDDFLNYMLQLQEK------KGLNAAELTSHTMTFLTDGFETTAQVLTHTL 319
            : ::..|.....:||.|||..|:..|..      |.|:..|:.:.::.|:..|:|||:..|:..|
  Rat   255 R-MKENRMKEKEKQRMDFLQLMINSQNSKVKDSHKALSDVEIVAQSVIFIFAGYETTSSALSFVL 318

  Fly   320 LFLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCEL 379
            ..||.:|..|.||::||     ..|..|::.:.::.:.:..::||||::.......:|.....|:
  Rat   319 YLLAIHPDIQKKLQDEIDAALPNKAHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEI 383

  Fly   380 TNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQ---GLFFGFGD 441
               |||.:.  .|.||:||..|||.||.|:.||:.|:||||      :||.:|.   .::..||:
  Rat   384 ---NGVFIP--KGTVVMIPTFALHKDPHYWPEPEEFRPERF------SKKNQDNINPYMYLPFGN 437

  Fly   442 GPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTR 476
            |||.|.||||:|..:|.|||.:::||..:...:|:
  Rat   438 GPRNCIGMRFALMNMKVALVRVLQNFSFQPCKETQ 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	131/463 (28%)
Cyp3a9	NP_671739.2	p450	39..493	CDD:278495	131/463 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820