Protein Alignment Cyp28d1 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_608912.1
• Gene: Cyp28d1 / 33749
• FlyBaseID: FBgn0031689
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 111/515 - (21%)
• Similarity: 193/515 - (37%)
• Gaps: 94/515 - (18%)

  Fly     4 ISTALFVIAAILALIYVF-LTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQK-----RNVVYDIDE 62
            :|..|...|..|:|:|:. |..........|:   ||.|::.| |..|...     ::.:..::.
Human    33 LSMLLIACAFTLSLVYLIRLAAGHLVQLPAGV---KSPPYIFS-PIPFLGHAIAFGKSPIEFLEN 93

  Fly    63 IYEQYKNTDSIVGVFQTRIPQLMVTTPEYAHKIYVSD-----FRSFHDNEMAKFTDSK-TDPILA 121
            .||:|....|...|.:|           :.: :..||     |.|.:::..|:...|: |.|:..
Human    94 AYEKYGPVFSFTMVGKT-----------FTY-LLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG 146

  Fly   122 N-------NPFVLTGEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLN 179
            .       ||..|      |::..:..||:....|....:..:..|::.|          :.|.:
Human   147 KGVAYDVPNPVFL------EQKKMLKSGLNIAHFKQHVSIIEKETKEYFE----------SWGES 195

  Fly   180 AKDLCLCYTTEVI----SDCVLGISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVANLWPPITK 240
            .:.......:|:|    |.|:.|...:|..:..     :.:...:...||.....:...|.|:..
Human   196 GEKNVFEALSELIILTASHCLHGKEIRSQLNEK-----VAQLYADLDGGFSHAAWLLPGWLPLPS 255

  Fly   241 FYSVSLFAKDVAAFFYDLMQKCIQVRRESPAAQQRDDFLNYMLQLQEKKG--LNAAELTSHTMTF 303
            |.......:::...||    |.||.||:|  .::.||.|..:|....|.|  |...|:....:..
Human   256 FRRRDRAHREIKDIFY----KAIQKRRQS--QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGL 314

  Fly   304 LTDGFETTAQVLTHTLLFLARNPKEQMKLREEIGTA------ELTFEQISELPFTEACIHETLRI 362
            |..|..|::........||||:...|.|...|..|.      .||::|:.:|...:.||.||||:
Human   315 LLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRL 379

  Fly   363 FSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNIN-GG 426
            ..|::...::...|     :......:.||..|.:...........:.|...|.|:|:|..| ..
Human   380 RPPIMIMMRMARTP-----QTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPAS 439

  Fly   427 AKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYF 486
            .:|:    .:..||.|...|.|..|:..|||.....::|.::.          ::.|.||
Human   440 GEKF----AYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEF----------DLIDGYF 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	CYP6-like	69..495	CDD:410679	94/444 (21%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	97/450 (22%)