DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	492	Identity:	141/492 - (28%)
Similarity:	247/492 - (50%)	Gaps:	47/492 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNTDSIV 74
            ::|..|.|:|::.|.....:|:.|||.....|.:|:..|.    |..::..|.  |.||....:.
Human    14 LLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY----RQGLWKFDT--ECYKKYGKMW 72

  Fly    75 GVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDN--EMAKFTDSKTDPILANNPFVLTGEAWKERRA 137
            |.::.::|.|.:|.|:....:.|.:..|...|  .:......|:...||.:      |.||..|:
Human    73 GTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAED------EEWKRIRS 131

  Fly   138 EVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVLGISAQ 202
            .::|..::.::|..:|:..:.....|..:||::  ...:.:..||:...|:.:||:....|::..
Human   132 LLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREA--EKGKPVTLKDIFGAYSMDVITGTSFGVNID 194

  Fly   203 SFTDNPTPMVGMTKRVFEQSFGF---IFYTVVANLWP---PITKFYSVSLFAKDVAAFFYDLMQK 261
            |..:...|.|..||:..:  |||   :|.:::  |:|   |:.:..:||||.||...|....:.:
Human   195 SLNNPQDPFVESTKKFLK--FGFLDPLFLSII--LFPFLTPVFEALNVSLFPKDTINFLSKSVNR 255

  Fly   262 CIQVRRESPAAQQRDDFLNYMLQLQEK------KGLNAAELTSHTMTFLTDGFETTAQVLTHTLL 320
             ::..|.:...:.|.|||..|:..|..      |.|:..||.:.::.|:..|:|||:.||:.||.
Human   256 -MKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 319

  Fly   321 FLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELT 380
            .||.:|..|.||::||     ..|..|::.:.::.:.:..::||||:|...:...:...:..|:
Human   320 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI- 383

  Fly   381 NKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRI 445
              |||.:.  .|.:|:||..||||||:|:.||:.|:||||    ...|...|..::..||.|||.
Human   384 --NGVFIP--KGSMVVIPTYALHHDPKYWTEPEEFRPERF----SKKKDSIDPYIYTPFGTGPRN 440

  Fly   446 CPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEID 482
            |.||||:|..:|.||:.:::||..|...:|:...::|
Human   441 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	132/460 (29%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	133/467 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820