DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp7b1

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_031851.3	Gene:	Cyp7b1 / 13123	MGIID:	104978	Length:	507	Species:	Mus musculus

Alignment Length:	532	Identity:	112/532 - (21%)
Similarity:	212/532 - (39%)	Gaps:	136/532 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PISTALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSW-PFVGSFPSVFTQKRNVVYDIDEIYEQ 66
            |::....:.||.|.|..:||....:. :.|..|..|.| |::|.....|   ::.:..:..:..|
Mouse    14 PLALLGLLFAATLLLSALFLLTRRTR-RPREPPLIKGWLPYLGMALKFF---KDPLTFLKTLQRQ 74

  Fly    67 YKNTDSI--VGVFQTRIPQLMVTTP-EYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLT 128
            :.:|.::  ||.:.|     .|..| :|.:                          :..||..|:
Mouse    75 HGDTFTVFLVGKYIT-----FVLNPFQYQY--------------------------VTKNPKQLS 108

  Fly   129 GEAWKERRAEVTPGLSANRVKAAYPVSLRVCKKFV------EYIRRQSLMAPAQGLNA-KDLCLC 186
            .:.:..|       |||.    |:.|     ||.:      |.:.|..|:...:.|:| .:..:.
Mouse   109 FQKFSSR-------LSAK----AFSV-----KKLLTDDDLNEDVHRAYLLLQGKPLDALLETMIQ 157

  Fly   187 YTTEVISDCVLGISAQSFTDNPTPMVGMTKRVFEQSFGFIFYTVVA------------------N 233
            ...|:....:|.|:..: |:......|  ..|||.:|..::..::|                  :
Mouse   158 EVKELFESQLLKITDWN-TERIFAFCG--SLVFEITFATLYGKILAGNKKQIISELRDDFFKFDD 219

  Fly   234 LWPPITKFYSVSLFAKDVAAFFYDLMQ----KCI------QVRRESPAAQQRDDFLNYMLQLQEK 288
            ::|.:.....:.|...:      :.||    ||:      |::.:|...|:|.|.|....:..:
Mouse   220 MFPYLVSDIPIQLLRNE------ESMQKKIIKCLTSEKVAQMQGQSKIVQERQDLLKRYYRHDD- 277

  Fly   289 KGLNAAELTSHTMTFLTDGFETTAQVLTHTLLFLARNPKEQMKLREEIG--------------TA 339
                 .|:.:|.:.||......|...:...:.::.|:|:....||:||.              :.
Mouse   278 -----PEIGAHHLGFLWASLANTIPAMFWAMYYILRHPEAMEALRDEIDSFLQSTGQKKGPGISV 337

  Fly   340 ELTFEQISELPFTEACIHETLRI--FSPVLAARKVVTEPCELTNKNGVSVKLRPGDVVIIPVNAL 402
            ..|.||:..|...|:.|.|.||:  :|.::   :.|.|...|:.:: .|..||.||.|.:....:
Mouse   338 HFTREQLDSLVCLESTILEVLRLCSYSSII---REVQEDMNLSLES-KSFSLRKGDFVALFPPLI 398

  Fly   403 HHDPQYYEEPQSFKPERFLNING--------GAKKYRDQGLFFGFGDGPRICPGMRFSLTQIKAA 459
            |:||:.::.|:.|:.:||:. :|        |.||.:...:.||.|...  |||..|::.::|..
Mouse   399 HNDPEIFDAPKEFRFDRFIE-DGKKKSTFFKGGKKLKTYVMPFGLGTSK--CPGRYFAVNEMKLL 460

  Fly   460 LVEIVRNFDIKV 471
            |:.::..||:::
Mouse   461 LIMLLTYFDLEI 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	104/500 (21%)
Cyp7b1	NP_031851.3	p450	50..487	CDD:386267	102/495 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5580
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860