DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d1 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	488	Identity:	145/488 - (29%)
Similarity:	247/488 - (50%)	Gaps:	36/488 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISTALFVIAAI-LALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQY 67
            :|...:|:.|| |.|:|.:.|.....:||:|||..|..||:|:..:.:  |....:|: |.|::|
Mouse     7 LSLETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTVLNYY--KGLWKFDM-ECYKKY 68

  Fly    68 KNTDSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAW 132
            ..|   .|:|..:.|.|.||.||....:.|.:..|...|.    .|.....|::....:...:.|
Mouse    69 GKT---WGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNR----RDFGPVGIMSKAISISKDDEW 126

  Fly   133 KERRAEVTPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCVL 197
            |..||.::|..::.::|..:||..:.....|:|:|:::  ...:.:..||:...|:.:||:....
Mouse   127 KRYRALLSPTFTSGKLKEMFPVIEQYGDILVKYLRQKA--KKGKPVTMKDVLGAYSMDVITSTSF 189

  Fly   198 GISAQSFTDNPTPMVGMTKRVFEQSF--GFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLMQ 260
            |::..|..:...|.|...|::....|  ..:|..|:.....|:.:..::.:|.||...||...:.
Mouse   190 GVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTPVYEMLNICMFPKDSIEFFKKFVD 254

  Fly   261 KCIQVRRESPAAQQRDDFLNYMLQLQEK-------KGLNAAELTSHTMTFLTDGFETTAQVLTHT 318
            :..:.|.:| ..:.|.|||..|:.....       |.|:..|:|:.::.|:..|:|||:..|:.|
Mouse   255 RMKESRLDS-KQKHRVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSIIFIFAGYETTSSTLSFT 318

  Fly   319 LLFLARNPKEQMKLREEI-----GTAELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCE 378
            |..||.:|..|.||::||     ..|..|::.:.|:.:.:..::||||::.......:|..:..|
Mouse   319 LHSLATHPDIQKKLQDEIDEALPNKAPPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVE 383

  Fly   379 LTNKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGP 443
            |   |||.:.  .|..|:||..|||||||::.||:.|:||||...|.|:   .|..::..||:||
Mouse   384 L---NGVYIP--KGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGS---IDPYVYLPFGNGP 440

  Fly   444 RICPGMRFSLTQIKAALVEIVRNFDIKVNPKTR 476
            |.|.||||:|..:|.||.:|::||..:...:|:
Mouse   441 RNCLGMRFALMNMKLALTKIMQNFSFQPCKETQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	133/456 (29%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	133/456 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820