Protein Alignment Cyp28d2 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_608911.1
• Gene: Cyp28d2 / 33748
• FlyBaseID: FBgn0031688
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 123/560 - (21%)
• Similarity: 220/560 - (39%)
• Gaps: 128/560 - (22%)

  Fly     8 LVLVLTLLVLVYVFLTWNFNYWRK-RGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKDTD 71
            |:||....:|.:| |.|.:.::.. |.::..|..|           :||..:....:....::..
Human    22 LLLVGASWLLAHV-LAWTYAFYDNCRRLRCFPQPP-----------RRNWFWGHQGMVNPTEEGM 74

  Fly    72 NMVGVFTTRVPQ-----------LLVMC-PEYIHKIYATD---------FRSFHNNEWRNFVNKK 115
            .::.......||           ||.:| |:.|..:....         |.|| ...|
Human    75 RVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSF-LEPW------- 131

  Fly   116 TDMILGNNPFVLTGDEWKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDA 180
                ||:...:..||:|...|..:.||...|.:|..    ..:..:.|..:..:.|:..|||...
Human   132 ----LGDGLLLSAGDKWSRHRRMLTPAFHFNILKPY----MKIFNESVNIMHAKWQLLASEGSAC 188

  Fly   181 MD----LSLCYTTEVVSDCGLGVSAQSFTDTPTPLLKMI--------KRVFN--TSFEFIFYSVV 231
            :|    :|| .|.:.:..|.....:.. .:.|:..:..|        ||...  ...:|::|  :
Human   189 LDMFEHISL-MTLDSLQKCVFSFDSHC-QEKPSEYIAAILELSALVSKRHHEILLHIDFLYY--L 249

  Fly   232 TNLWQKVRKFYSVPFFNKETEVFFLDII----RRCITLRLEKPEQQRDDFL------------NY 280
            |...|:.|:...:..       .|.|.:    ||.:      |.|..||||            :.
Human   250 TPDGQRFRRACRLVH-------DFTDAVIQERRRTL------PSQGVDDFLQAKAKSKTLDFIDV 301

  Fly   281 MLQLQEKKG--LHTDNILINTMTFILDGFETTALVLAHIMLMLGRNPEEQDKVRKEIGS------ 337
            :|..:::.|  |..::|.....||:.:|.:|||..|:.::..|.::||.|::.|:|:..
Human   302 LLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDRE 366

  Fly   338 -ADLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPFEFANKNGRTVHLKPGDVVTIPVKAL 401
             .::.:|.::.||.|..|:.|:|||..|.....:.||:  :....:||.:  ..|.:..|.|...
Human   367 PKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQ--DIVLPDGRVI--PKGIICLISVFGT 427

  Fly   402 HHDPQYYEDPLTFKPERFLESNGGGMKSYRDRG--VYLAFGDGPRHCPGMRFALTQLKAALVEIL 464
            ||:|..:.||..:.|.||...|      .::|.  .::.|..|||:|.|..||:.::|..|...|
Human   428 HHNPAVWPDPEVYDPFRFDPEN------IKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTL 486

  Fly   465 RNFEI---KVNPKTRSDNQIDDTFFMATLKGGIYLDFKDL 501
            ..|.:   ...|:.:.:       .:...:||::|..:.|
Human   487 LRFRVLPDHTEPRRKPE-------LVLRAEGGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	CYP6-like	74..495	CDD:410679	109/485 (22%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	109/490 (22%)