Protein Alignment Cyp28d2 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_608911.1
• Gene: Cyp28d2 / 33748
• FlyBaseID: FBgn0031688
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 608
• Identity: 140/608 - (23%)
• Similarity: 230/608 - (37%)
• Gaps: 161/608 - (26%)

  Fly     3 PVTTFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKY 67
            |:.| :.|.:.||.|:..:.|..|:...|.|::.....||:|          |:.:.....:|..
Human    14 PMVT-VALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIG----------NLTFFRQGFWESQ 67

  Fly    68 KDTDN----MVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNN-----EWRNFVNKKTDMILGNN 123
            .:...    :.|.:..|...:::..|:.|.::...:|.:|.|.     |:::.    .|.:|
Human    68 MELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV----ADSVL--- 125

  Fly   124 PFVLTGDEWKERRSEIMPALSP------------NRVK---------------------AVY--- 152
              .|....|:|.|..:|.|.||            .|:|                     .:|
Human   126 --FLRDKRWEEVRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNL 188

  Fly   153 ----------PVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLC---YTTEVVSDCGLGVSAQSF 204
                      |:....|...:.:::|.     :|..||.|:..|   |||:||:....|....|:
Human   189 HYATLPFCMVPLISQACDLLLAHLKRY-----AESGDAFDIQRCYCNYTTDVVASVAFGTPVDSW 248

  Fly   205 TDTPTPLLKMIKRVFN-----------TSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDI 258
            .....|.:|..||.|.           .||..|...:...|..|.|         .|...||..:
Human   249 QAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNR---------DELNGFFNKL 304

  Fly   259 IRRCITLR-LEKPEQQRDDFLNYMLQLQEK----------------------------------- 287
            ||..|.|| .:..|::|.|||..:|..:..
Human   305 IRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMA 369

  Fly   288 KGLHTDNILINTMTFILDGFETTALVLAHIMLMLGRNPEEQDKVRKEIGSADL--------TFDQ 344
            :.|..|.|:.....|::.|:|.....|:....:|..||:.|:|:.:|:   |:        .|..
Human   370 RPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV---DVFKEKHMAPEFCS 431

  Fly   345 MSE-LPHLDACIYETLRLFSPQVAARKLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYY 408
            :.| ||:||..|.||||::.|.....:...:..|...:     .:..|.|:.:.|.||||||:::
Human   432 LEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQ-----RIPAGAVLEMAVGALHHDPEHW 491

  Fly   409 EDPLTFKPERFLESNGGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNP 473
            ..|.||.||||........:.:    .||.||.|||.|.|:|..|.::|..|:.:|..|..:..|
Human   492 PSPETFNPERFTAEARQQHRPF----TYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACP 552

  Fly   474 KTRSDNQIDDTFFMATLKGGIYL 496
            :|:...|::....:.. |.|:|:
Human   553 ETQVPLQLESKSALGP-KNGVYI 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	CYP6-like	74..495	CDD:410679	124/530 (23%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	124/535 (23%)