Protein Alignment Cyp28d2 and CYP3A43

DIOPT Version :9

• Sequence 1: NP_608911.1
• Gene: Cyp28d2 / 33748
• FlyBaseID: FBgn0031688
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 142/496 - (28%)
• Similarity: 238/496 - (47%)
• Gaps: 49/496 - (9%)

  Fly     9 VLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDID-DIYEKYKDTDN 72
            |||.|.|||:|::.|.:...::|.||......||:|   :|....|.: ::.| :..|||.:
Human    13 VLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLG---TILFYLRGL-WNFDRECNEKYGE--- 70

  Fly    73 MVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTG------DE 131
            |.|::..:.|.|::|.|:.|..:...:..|...|:          |.||...|:.:.      :|
Human    71 MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQ----------MPLGPMGFLKSALSFAEDEE 125

  Fly   132 WKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCG 196
            ||..|:.:.||.:..:.|.:.|:........|..:|  |:...|:.::..|....||.:|::...
Human   126 WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLR--QEAENSKSINLKDFFGAYTMDVITGTL 188

  Fly   197 LGVSAQSFTDTPTPLLKMIKRVFNTSF--EFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDII 259
            .||:..|..:...|.||.:|::....|  .|:....:......|.:..::..|.|:...|..:.|
Human   189 FGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSI 253

  Fly   260 RRCITLRLEKPEQQRDDFLNYMLQLQEK------KGLHTDNILINTMTFILDGFETTALVLAHIM 318
            .|....||:..::.|.||...|:..|..      |.|....::..::..|...::||:..|..||
Human   254 ERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIM 318

  Fly   319 LMLGRNPEEQDKVRKEI-----GSADLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPFEF 378
            ..|..:|:.|.|:::||     ..|.:|:|.:.::.:||..:.||||||.......::..:..|.
Human   319 YELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEI 383

  Fly   379 ANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPE-RFLESNGGGMKSYRDRGVYLAFGDG 442
               ||  |.:..|..|.:|:.||||||:|:.:|..|.|| ||.:.|...:..||    |:.||.|
Human   384 ---NG--VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYR----YIPFGAG 439

  Fly   443 PRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDD 483
            ||:|.|||||||.:|.|::..|:||..|...:|:...::|:
Human   440 PRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	128/457 (28%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	130/470 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820