DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp6a22

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001286431.1	Gene:	Cyp6a22 / 49847	FlyBaseID:	FBgn0013773	Length:	499	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	145/512 - (28%)
Similarity:	240/512 - (46%)	Gaps:	40/512 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKDTD- 71
            :.|:|..|.:.:.|:...::||.:|||.:.|....||:... |.:.::....:..||||:|...
  Fly     5 VALLLIALAVGFWFVRTRYSYWTRRGIGSEPARFPVGNMEG-FRKNKHFIDIVTPIYEKFKGNGA 68

  Fly    72 NMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWKERR 136
            ...|.|....|.:||...|...:|...||.:|   |.|...:.:.|..|..:.|.:.|.:|:..|
  Fly    69 PFAGFFMMLRPVVLVTDLELAKQILIQDFANF---EDRGMYHNERDDPLTGHLFRIDGPKWRPLR 130

  Fly   137 SEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLGVSA 201
            .::.|..:..::|.::|....|.::..:........|....|:..||...||::|:..|..||..
  Fly   131 QKMSPTFTSAKMKYMFPTVCEVGEELTQVCGELADNAMCGILEIGDLMARYTSDVIGRCAFGVEC 195

  Fly   202 QSFTDTPTPLLKMIKRVFNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDIIRRCITLR 266
            ....:.......|.:|.|:..............:.:|.:|..:...:::...|::.|:|..:..|
  Fly   196 NGLRNPEAEFAIMGRRAFSERRHCKLVDGFIESFPEVARFLRMRQIHQDITDFYVGIVRETVKQR 260

  Fly   267 LEKPEQQ---RDDFLNYMLQLQEKKGLHTDNILINTMTFILDGFETTALVLAHIMLMLGRNPEEQ 328
                |:|   |.||:|.:::::::..|..:.:......|...||:|:|..|...:..|.:.|..|
  Fly   261 ----EEQGIVRSDFMNLLIEMKQRGELTIEEMAAQAFIFFAAGFDTSASTLGFALYELAKQPALQ 321

  Fly   329 DKVRKEIGSA------DLTFDQMSELPHLDACIYETLRLFS--PQVA--ARKLVTEPFEFANKNG 383
            .|:|:||..|      :.|:|.|.||.:::..|.||||.:.  ||:.  :|.|      :|.|..
  Fly   322 AKLREEIDQALRLHNGEFTYDSMQELRYMELVIAETLRKYPILPQLTRISRHL------YAAKGD 380

  Fly   384 RTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFGDGPRHCPG 448
            |..:::||.::.|||..:||||..|.:|..|.|||||    ....:.|....:|.||||||:|.|
  Fly   381 RHFYIEPGQMLLIPVYGIHHDPALYPEPHKFIPERFL----ADQLAQRPTAAWLPFGDGPRNCIG 441

  Fly   449 MRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMATL----KGGIYLDFKDL 501
            |||...|....||.:||||...|.|:|  |.:|:  |..:.:    ..||||..:.|
  Fly   442 MRFGKMQTTIGLVSLLRNFHFSVCPRT--DPKIE--FLKSNILLCPANGIYLKVQQL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	127/450 (28%)
Cyp6a22	NP_001286431.1	p450	35..491	CDD:278495	135/477 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460963
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900