DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	506	Identity:	137/506 - (27%)
Similarity:	236/506 - (46%)	Gaps:	57/506 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKDT 70
            |.:.||:|||   |::..|...:::|.||.....|||.|:|.| :| |....:|: :..:||
Zfish    12 TLVFLVITLL---YMYGVWPHGFFKKLGIPGPRPWPFFGTFLS-YT-KGFFNFDM-ECAKKY--- 67

  Fly    71 DNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWKER 135
            ..:.|::..|:|.|:|...|.|..|...:..|...|  |..||......|.:....:..:.||..
Zfish    68 GKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTN--RREVNVDLAGPLADGISAVKDERWKRI 130

  Fly   136 RSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLGVS 200
            |..:.|..:..|:|.::|::.:...:|   |:..|:....:.:...::...|:.:||:.....|.
Zfish   131 RGTLSPYFTSGRLKEIFPIAMTHADRF---IKNMQKRDHEQPVKIKEVVAPYSLDVVTSSSFSVD 192

  Fly   201 AQSFTDTPTPLLKMIKR-----VFNTSFEFI-FYSVVTNLWQKVRKFYSVPFFNKETEVFFLDII 259
            ..|..:...|.:..||.     :|:....|: .:..:.||..|:    .:..|::....||...:
Zfish   193 IDSINNPDDPFVTNIKNFLKFSLFSPLILFLTLFPSIANLLGKM----GISVFSRSIMNFFYTAL 253

  Fly   260 RRCITLRLE-KPEQQRDDFLNYMLQ-------------LQEKKGLHTDNILINTMTFILDGFETT 310
            |:   ::.| |....|.|||..|:|             .|..|||....||..:..|||.|:|||
Zfish   254 RK---IKDEHKDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGGYETT 315

  Fly   311 ALVLAHIMLMLGRNPEEQDKVRKEIG-----SADLTFDQMSELPHLDACIYETLRLFSPQVAARK 370
            :..|:.::..|..||:..:|:.:||.     ...:::|.:.::.:|:..|.|::||........:
Zfish   316 STTLSFLLHNLATNPDCLEKLVEEIDKNFPLDTPISYDALMKMDYLEMSINESMRLLPTAPRLER 380

  Fly   371 LVTEPFEFANKNGRTVHLKPGD-VVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRG 434
            :..:..|.   ||.|:   |.| :|.||...|:.|||.::.|..|:||||...|......|
Zfish   381 VCKKTVEL---NGITI---PKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFLQY---- 435

  Fly   435 VYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTF 485
            .::.||.|||:|.||||||..:|..:|::|:||.::...:|:...::...|
Zfish   436 AFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLELTPVF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	124/462 (27%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	126/477 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820