DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp6d5

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	137/490 - (27%)
Similarity:	251/490 - (51%)	Gaps:	41/490 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLVLTLLVLVYVFLTWNFNYWRKRGI-KTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKDTD 71
            :.|::..:.|:||:|.|.|:||.::|. .|..:.|| |:..|:...||:....|.|:|:..|:.
  Fly     4 IYLLIAAVTLLYVYLKWTFSYWDRKGFPSTGVSIPF-GALESVTKGKRSFGMAIYDMYKSTKEP- 66

  Fly    72 NMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWKERR 136
             ::|::.|..|.|||...:..|.:...||.|||:.  ..:|::|.|. :..:.|.:.|..|:..|
  Fly    67 -VIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDR--GVYVDEKNDP-MSASLFQMEGASWRALR 127

  Fly   137 SEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLGVSA 201
            :::.|:.:..::||::..|.||..|.|:.||:|.....::.|:...|...|..::::....|:..
  Fly   128 NKLTPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPANGAKELELKKLMATYAIDIIATTIFGLDV 192

  Fly   202 QSFTDTPTPLLKMIKRVFNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDIIRRCITLR 266
            .||.|.......:.|:|...:.|.|.....:.|:..:.||:....:.:|......::..|.:.||
  Fly   193 DSFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVKIGWKQEATERMRELSNRTVDLR 257

  Fly   267 LEKPEQQRDDFLNYMLQLQEKKGLHTDNIL---------INTMT----------FILDGFETTAL 312
             |:....|.|.|..:|||:.:..::||:.:         :.:|:          |.:.|:||||.
  Fly   258 -EQNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNGVKSMSKDLIAGQLFLFYVAGYETTAS 321

  Fly   313 VLAHIMLMLGRNPEEQDKVRKEIGSA------DLTFDQMSELPHLDACIYETLRLFSPQVAARKL 371
            ..:..:..|.:|||..:|.::::.||      .||:|.:|::.:|:|||.||.|.:.......::
  Fly   322 TTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPALPLLNRI 386

  Fly   372 VTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVY 436
            .|:.:...:..   :.::.|..:.|.:..:|.|.:|:.|||.:||||:|| ||   |.| .:..|
  Fly   387 CTKDYPVPDSK---LVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYLE-NG---KDY-TQAAY 443

  Fly   437 LAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKV 471
            |.||:|||.|.|.|.....:|.|:.::|.||::::
  Fly   444 LPFGEGPRMCIGARMGKVNVKIAIAKVLSNFDLEI 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	126/459 (27%)
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	116/425 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460862
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	1	0.950	-	0	Normalized mean entropy	S5364
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.850