DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	142/519 - (27%)
Similarity:	236/519 - (45%)	Gaps:	52/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLVLVLTLLVLV-YVFLTWN--FNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYK 68
            :.||:..::||| |:.|.|.  .:||:...|........:||...:.| .|:.:....|.|.|::
  Fly     4 YSVLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPHILMGSLTGVQT-SRSFSAIWMDYYNKFR 67

  Fly    69 DTDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWK 133
            .|....|.:..:.|.:||:.......|...:|..|.:   |.|.:...|..|....|:|.|.:||
  Fly    68 GTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTD---RGFYHNTEDDPLSGQLFLLDGQKWK 129

  Fly   134 ERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLG 198
            ..||::....:..::|.::|....|..:|:|..  .|.|..|..::..|:...:||:|:..|..|
  Fly   130 SMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVF--GQAMEKSPIVEVRDILARFTTDVIGTCAFG 192

  Fly   199 VSAQSFTDTPTPLLKMIKRVFNTSFE---------FIFYSVVTNLWQKVRKFYSVPFFNKETEVF 254
            :...|..|.......|.:|..   ||         ||      |.:|.:.:...:....:|.|.|
  Fly   193 IECSSLKDPEAEFRVMGRRAI---FEQRHGPIGIAFI------NSFQNLARRLHMKITLEEAEHF 248

  Fly   255 FLDIIRRCITLRLEKPEQQRDDFLNYMLQLQ----------EKKGLHTDNILINTMTFILDGFET 309
            ||.|:|..:..| ||...:|:||::.::.|:          |...|..:.:......|...||||
  Fly   249 FLRIVRETVAFR-EKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQAFVFFGAGFET 312

  Fly   310 TALVLAHIMLMLGRNPEEQDKVRKE----IG--SADLTFDQMSELPHLDACIYETLRLFSPQVAA 368
            ::..:...:..|.::.:.||:||||    ||  :.::|::.|.::.:||..|.|||||::.....
  Fly   313 SSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPVL 377

  Fly   369 RKLVTEPFEFANKNGRTVH-LKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRD 432
            .:...|.:|..   |...: :|.|..|.||..|:|.|.:.|.:|.||.|:.|....   :|. ||
  Fly   378 NRECLEDYEVP---GHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPER---VKE-RD 435

  Fly   433 RGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMATLKGGIYL 496
            ...:|.||||||:|.||||...|.::.|..::..|:..|..:|..........|:.:.:.||:|
  Fly   436 SVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLISSETGIFL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	126/462 (27%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	130/486 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460956
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900