DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	154/513 - (30%)
Similarity:	252/513 - (49%)	Gaps:	42/513 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAY-DID-DIYEKYK 68
            |.||||.|:.:|:||.|.|:::||.:||:.......|.|:...:   .|::.: ||: .||.|::
  Fly     3 TLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGL---GRDLHWTDINLRIYRKFR 64

  Fly    69 DTDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWK 133
            ..:...|.||.....|.:|..|.|..|...||.||.:...  |.|.:.|.:.||..| |.|.||:
  Fly    65 GVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGL--FHNVRDDPLTGNLLF-LDGPEWR 126

  Fly   134 ERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLG 198
            ..|..:....:..::|.::|....|.:|..:..|.|    ..| ::|.||...:||:|:..|..|
  Fly   127 WLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQ----VGE-IEAKDLCARFTTDVIGSCAFG 186

  Fly   199 VSAQSFTDTPTPLLKMIKRVFNTSFEFI----FYSVVTNLWQKVRKFYSVPFFNKETEVFFLDII 259
            :...|..|..:...:|.:.|.......:    |......|.:|:|    ...|..|...||||.:
  Fly   187 LECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLR----FRLFRPEVSEFFLDTV 247

  Fly   260 RRCITLRLEKPEQQRDDFLNYMLQLQE---KKGLHTDNILINTMTFILDGFETTALVLAHIMLML 321
            |:.:..| .:....|:|.:..:::|.|   |..|..:.|....:.|.|.||:|::..::..:..|
  Fly   248 RQTLDYR-RRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYEL 311

  Fly   322 GRNPEEQDKVRKEI------GSADLTFDQMSELPHLDACIYETLRLFS--PQVAARKLVTEPFEF 378
            ..||:.|:::|.|:      .:..||:|.:.|:|:||..:.||||.:.  |.:..|.  |:.::.
  Fly   312 ALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRS--TKEYQI 374

  Fly   379 ANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFGDGP 443
            .|.|   :.|:||..:.|||.::||||:.|.||..|.|.||....   :|: |....||.||:||
  Fly   375 PNSN---LILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEE---IKA-RHPFAYLPFGEGP 432

  Fly   444 RHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMATLKGGIYLDFKDL 501
            |:|.|.||...|:|..||.:||:|:...:.||:...:.....|:.:.:.|::|..:.|
  Fly   433 RNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRMEGL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	133/453 (29%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	135/467 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460964
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900