DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	508	Identity:	121/508 - (23%)
Similarity:	238/508 - (46%)	Gaps:	35/508 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LVLTLLVLVYVFLTWN---FNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKDTD 71
            :.|.|:|:.|:...|:   |..:.:|.:.....:||||:..:...:|.:....:.:.||:.:. .
  Fly     6 ICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLTEFYERTRQ-H 69

  Fly    72 NMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWKERR 136
            .:||.|..|.|.:.:..||.|.|:...||..|.|::  .|:. ..|.:..:...|:....||..|
  Fly    70 KLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQ--PFIT-SNDRLFNDMLSVMRDQRWKHMR 131

  Fly   137 SEIMPALSPNRVKAVYPVSQSVCKKFVEYIRR----QQQMATSEGLDAMDLSLC--YTTEVVSDC 195
            :.:.|..:..:::.::.:..   :.|.|.::.    .:.:...:|.:.....:|  .:.::::..
  Fly   132 NTLTPVFTAAKMRNMFTLMN---ESFAECLQHLDSSSKTLPGRKGFEVDMKVMCNKLSNDIIATT 193

  Fly   196 GLGVSAQSFTDTPTPLLKMIKR--VFNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDI 258
            ..|:...|: |.|......|.:  ||:...:| |..:::.|..|:.....:..|:.....:|..:
  Fly   194 AFGLKVNSY-DNPKNEFYEIGQSLVFSRGLQF-FKFMLSTLVPKLFSLLKLTIFDSAKVDYFARL 256

  Fly   259 IRRCITLRLEKPEQQRDDFLNYMLQLQ-EKKGLHTDN-ILINTMTFILDGFETTALVLAHIMLML 321
            :...:..| ||....|.|.:..:::.: |.:...||: |:.....|....||..:.::......|
  Fly   257 VVEAMQYR-EKHNITRPDMIQLLMEAKNESEDKWTDDEIVAQCFIFFFAAFENNSNLICTTTYEL 320

  Fly   322 GRNPEEQDKV-------RKEIGSADLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPFEFA 379
            ..||:.|:::       :|.:..|.||:|.:.::.::|..|.|:||.::...|..:|.::.:...
  Fly   321 LYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWTLAAATDRLCSKDYTLT 385

  Fly   380 NKNG-RTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFGDGP 443
            :.:| :....|.||.:.||:..||.|.:|:.:|..|.|:||.|...|.|..|    .||.||.||
  Fly   386 DDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPY----TYLPFGVGP 446

  Fly   444 RHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMATLKGGIYL 496
            |:|.|.|:||.|:|..|..:|.:::|:.:|:|..|.....:.|..|.:.|.::
  Fly   447 RNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTPRSGFWM 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	109/454 (24%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	109/454 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460899
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	1	0.950	-	0	Normalized mean entropy	S5364
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.850