DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp6v1

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	133/537 - (24%)
Similarity:	247/537 - (45%)	Gaps:	71/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TTFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIY--EKY 67
            |..|:.::|:|..|:::....:.||::|.:|.......:|:...:...:.:.|..:...|  |::
  Fly     5 TNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERF 69

  Fly    68 KDTDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEW 132
            :: :.:||::....|.||:...:.:..:...||.||.|...:  .:.::|.:...:.|:....||
  Fly    70 RN-EPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAK--CDGRSDKMGALSLFLAKQPEW 131

  Fly   133 KERRSEIMPALSPNRVKAVYPVSQSV-C------KKFVEYIRR--QQQMATSEGLDAMDLSLCYT 188
            :|.|:.:.||.:..::|.::.:.:.: |      |:....:||  .::.|.....|..||   |.
  Fly   132 REIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDL---YN 193

  Fly   189 TEVVSDCGLGVSAQSFTDTPTPLLKMIKRVFNTSFE------FIFYSVVTNLWQKVR-KFYSVPF 246
            |::::....|:.:.|..:|.:.:....:.:|..:..      .|||  :..|...:| |.::.|
  Fly   194 TDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIFY--LPKLVPLLRPKLFTEP- 255

  Fly   247 FNKETEVFFLDIIRRCITLRLEKPEQ---QRDDFLNYMLQLQEKKGL---------HTDNILINT 299
                    ..:.:||.|.|.:|:.|:   .|:|.:..:|.|:::..|         |.|.:....
  Fly   256 --------HAEFLRRVIQLVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLAAQA 312

  Fly   300 MTFILDGFETTALVLAHIMLMLGRNPEEQDKVRKEIGSA-------DLTFDQMSELPHLDACIYE 357
            .:|.:.|.||.:..::..:..|.:.|..|.::|:||..|       .||::.::.:..||..:.|
  Fly   313 ASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEE 377

  Fly   358 TLRLFSPQVAARKLVTEPFEFANKNGRTVHLKP--------GDVVTIPVKALHHDPQYYEDPLTF 414
            |||.: |.|...:....|.   ||. |...|:|        |..|.|...|:||||:|:.||..|
  Fly   378 TLRKY-PIVPLLERECTPI---NKK-RFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRF 437

  Fly   415 KPERFLESNGGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDN 479
            .||||..:|    |:.:....|:.||.|||:|.||:..|.|:|..||..|....:::..:|....
  Fly   438 DPERFSAAN----KALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERI 498

  Fly   480 QIDDTFFMATLKGGIYL 496
            |.|..|.:...:..|||
  Fly   499 QFDAKFALLASEQRIYL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	117/481 (24%)
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	122/483 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460829
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900