DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp308a1

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	143/531 - (26%)
Similarity:	240/531 - (45%)	Gaps:	79/531 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCPVTTFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYE 65
            |.|:..|::|..|||     |..|..|:||:.|::....||.||:.......:|:......:||.
  Fly     1 MLPLVLFILLAATLL-----FWKWQGNHWRRLGLEAPFGWPLVGNMLDFALGRRSYGEIYQEIYT 60

  Fly    66 -----KYKDTDNMVGVFTT-RVPQLLVMCPEYIHKI-YATDFRSFHNNEWRNFVNKKTDMILGNN 123
                 ||      ||.:.. ..|.:||...|.:.:| ...:|....:|  ..:|:.:.|::..:|
  Fly    61 RNPGLKY------VGFYRLFNEPAILVRDQELLRQILVGRNFADCADN--AVYVDHQRDVLASHN 117

  Fly   124 PFVLTGDEWKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYT 188
            ||:..||.|:..|::::|..:|:||:...|.....|    :.:|.|..:...|   |.||:..||
  Fly   118 PFIANGDRWRVLRADLVPLFTPSRVRQTLPHVARAC----QLLRDQVPLGRFE---AKDLATRYT 175

  Fly   189 TEVVSDCGLGVSAQSF------TDTPTPLLKMIKRVFNTSFEFIFYSVVTNLWQ--KVRKFYSVP 245
            .:||:....|:.|...      ...|:..|:.:..:|..|           :|.  :.......|
  Fly   176 LQVVASAIFGLDAHCLGIHMRVAHEPSRWLEWLAPLFQPS-----------VWSLLETMSLLHTP 229

  Fly   246 FFNKETEVFFLDIIRRCITLRLE-------KPEQQRDDFLNYMLQLQEKKGLHTDNILINTMTFI 303
            ...:.       |..|.:.|.|:       :.....|:.|.::  .:.|:||..:.:..:..|.:
  Fly   230 RLGRL-------IGHRYVPLPLQHWFRELVEARSGGDNLLQWL--AESKRGLGKEELAGHATTLL 285

  Fly   304 LDGFETTALVLAHIMLMLGRNPEEQDKVRKEIGS-----ADLTFD--QMSELPHLDACIYETLRL 361
            |:|:||:|::||..:..|..|.:.|.::..|:..     |....|  .:.||.:.:|.:.|.|||
  Fly   286 LEGYETSAMLLAFALYELALNEDAQRRLHIELDEVAQRHAGNLIDPVALGELRYSEAALLEALRL 350

  Fly   362 FSPQVAARKLVTEPFEFAN-KNGRTVHLKP--GDVVTIPVKALHHDPQYYEDPLTFKPERFLESN 423
            .....|.:|..|:.|...: |:|.:..||.  |.|:.:||:|:|.||..|..|..|:|||||...
  Fly   351 HPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTVLVLPVQAIHLDPALYPAPNQFRPERFLNQP 415

  Fly   424 GGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMA 488
            ..|.:       :|.||.|||.|||||..|.|.||||..:|::..:::..:.:...::....|:.
  Fly   416 PMGCR-------FLGFGAGPRMCPGMRLGLLQTKAALTTLLQDHCVQLADEDQCRVEVSPLTFLT 473

  Fly   489 TLKGGIYLDFK 499
            ..:.||:|.||
  Fly   474 ASRNGIWLSFK 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	124/468 (26%)
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	127/490 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45472980
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900