Protein Alignment Cyp28d2 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_608911.1
• Gene: Cyp28d2 / 33748
• FlyBaseID: FBgn0031688
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 135/538 - (25%)
• Similarity: 230/538 - (42%)
• Gaps: 96/538 - (17%)

  Fly    10 LVLTLLVLVYVFLTWNFNYWRK----RGIKT-APTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKD 69
            |||:||..|       .:|.||    |.|.| |..:|.||....:....|.....|.:..|:|:.
Human    29 LVLSLLQRV-------ASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRH 86

  Fly    70 TDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWKE 134
            .. ::.::...||.:.:...|.: ::..|..:....:....|:    :..||......||::|:.
Human    87 MP-LLKLWVGPVPMVALYNAENV-EVILTSSKQIDKSSMYKFL----EPWLGLGLLTSTGNKWRS 145

  Fly   135 RRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSE-----GLDAMD----LSLCYTTE 190
            ||..:.|..           ..::.:.|::.:..|..:...:     ..:|.:    ::|| ..:
Human   146 RRKMLTPTF-----------HFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLC-ALD 198

  Fly   191 VVSDCGLG--VSAQSFTDTPTPLLKMIKRVFNTSFEFIF-------------YSVVTNLWQKVRK 240
            ::.:..:|  :.|||..|:     :.::.|:..| |.||             |.:....|:..:.
Human   199 IICETAMGKNIGAQSNDDS-----EYVRAVYRMS-EMIFRRIKMPWLWLDLWYLMFKEGWEHKKS 257

  Fly   241 FYSVPFFNKETEVFFLDIIRRCITLRLEK-----------PEQQRDDFLNYMLQLQEKKG--LHT 292
            ...:..|....      |..|...:...:           .:.:|..||:.:|.:.:.:|  |..
Human   258 LQILHTFTNSV------IAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSH 316

  Fly   293 DNILINTMTFILDGFETTALVLAHIMLMLGRNPEEQDKVRKEI----GSAD--LTFDQMSELPHL 351
            ::|.....||:.:|.:|||..:...:.:||.|||.|.||..|:    |.:|  .|.:.:.:|.:|
Human   317 EDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYL 381

  Fly   352 DACIYETLRLFSPQVAARKLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKP 416
            :..|.||||||.......:.|:|..|.|   |..| ||..:.|.||. |||.||:|:.:|..|:|
Human   382 ECVIKETLRLFPSVPLFARSVSEDCEVA---GYRV-LKGTEAVIIPY-ALHRDPRYFPNPEEFQP 441

  Fly   417 ERFLESNGGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQI 481
            |||...|..|...|    .|:.|..|||:|.|.:||:.:.|..|..|||:|.|:.|.| |.:..:
Human   442 ERFFPENAQGRHPY----AYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQK-REELGL 501

  Fly   482 DDTFFMATLKGGIYLDFK 499
            :....:.. ..||::..|
Human   502 EGQLILRP-SNGIWIKLK 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	CYP6-like	74..495	CDD:410679	113/463 (24%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	117/479 (24%)