DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	143/490 - (29%)
Similarity:	241/490 - (49%)	Gaps:	51/490 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKDTDNM 73
            ||:..:|||:|...|.....::|:||......||:|:..:.:  |....:|: :.|:||   ..:
  Rat    13 VLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYY--KGLGRFDM-ECYKKY---GKI 71

  Fly    74 VGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNF--VNKKTDMILGNNPFVLTGDEWKERR 136
            .|:|..:.|...:|..|.|..:...:..|...|. |:|  |.     |:|....|...:|||..|
  Rat    72 WGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNR-RDFGPVG-----IMGKAVSVAKDEEWKRYR 130

  Fly   137 SEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLGVSA 201
            :.:.|..:..|:|.::|:.:......|:|::  |:..|.:.:....:...|:.:|::....||:.
  Rat   131 ALLSPTFTSGRLKEMFPIIEQYGDILVKYLK--QEAETGKPVTMKKVFGAYSMDVITSTSFGVNV 193

  Fly   202 QSFTDTPTPLLKMIKRVFNTSFEF---IFYSVV-----TNLWQKVRKFYSVPFFNKETEVFFLDI 258
            .|..:...|.::..|::..  |:|   :|.|||     |.:::.:    ::..|.|::..||...
  Rat   194 DSLNNPKDPFVEKTKKLLR--FDFFDPLFLSVVLFPFLTPIYEML----NICMFPKDSIAFFQKF 252

  Fly   259 IRRCITLRLEKPEQQRDDFLNYMLQLQEK-------KGLHTDNILINTMTFILDGFETTALVLAH 316
            :.|....||:...:.|.|||..||.....       |.|....|:..::.||..|:|||:..|:.
  Rat   253 VHRIKETRLDSKHKHRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQSVIFIFAGYETTSSTLSF 317

  Fly   317 IMLMLGRNPEEQDKVRKEI-----GSADLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPF 376
            ::..|..:|:.|.|:::||     ..|..|:|.:.|:.:||..:.|||||:.......::..:..
  Rat   318 VLYFLATHPDIQKKLQEEIDGALPSKAPPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDI 382

  Fly   377 EFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFGD 441
            |...     :.:..|.|||||..|||||||::..|..|.||||.:.|.|.:..|    |||.||:
  Rat   383 ELDG-----LFIPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPY----VYLPFGN 438

  Fly   442 GPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTR 476
            |||:|.||||||..:|.||.::|:||..:...:|:
  Rat   439 GPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQ 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	132/458 (29%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	127/433 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920