DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and erg5

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_593788.2	Gene:	erg5 / 2542469	PomBaseID:	SPAC19A8.04	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	533	Identity:	110/533 - (20%)
Similarity:	204/533 - (38%)	Gaps:	128/533 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 NYWRKRGIKTAPTW--PFVGSFPSIFTRKRNIAYDIDDI---YEKYK---DTD--NMVGVFTTRV 81
            :|..::|....|.:  ||:|||             :|.:   :|||.   .|.  :.|.||...|
pombe    46 SYQMQKGHIPGPRFKIPFMGSF-------------LDSMKPTFEKYNAKWQTGPLSCVSVFHKFV 97

  Fly    82 --------PQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDEWKERRSE 138
                    .:.::..|.|:...               .|:....::...|...|.|.:..|.|..
pombe    98 VIASERDLARKILNSPSYVQPC---------------VVDAGKKILKHTNWVFLDGRDHIEYRKG 147

  Fly   139 IMPALSPNRVKAVYPVSQSVCKK-FVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGLGVSAQ 202
            :....:...:.:..|..::|..| |.|::...:.......:...|:::  .|...:.||..:|..
pombe   148 LNGLFTTRALASYLPAQEAVYNKYFKEFLAHSKDDYAQYMIPFRDINV--ATSCRTFCGYYISDD 210

  Fly   203 SFTDTPTPLLKMIKRVFNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDIIRRCITLRL 267
            :.........|:     ..:.|.:.:.:|            :||    |:|:: .|..|.:.:|.
pombe   211 AIKHIADEYWKI-----TAAMELVNFPIV------------LPF----TKVWY-GIQSRKVVMRY 253

  Fly   268 ---------------EKPEQQRDDFLNYMLQL-----QEKKGLHTDNILINT----------MTF 302
                           ..|....:::::.|::.     :.|:|....::||..          ::|
pombe   254 FMKAAAESRKNMEAGNAPACMMEEWIHEMIETRKYKSENKEGAEKPSVLIREFSDEEISLTFLSF 318

  Fly   303 ILDGFETTALVLAHIMLMLGRNPEEQDKVRKE-----IGSAD--LTFDQMSELPHLDACIYETLR 360
            :....:.|:..:..:..:|..:|:...|||:|     .|..|  |:.|.|.::.:..|.:.|.||
pombe   319 LFASQDATSSAMTWLFQLLADHPDVLQKVREEQLRIRKGDIDVPLSLDLMEKMTYTRAVVKECLR 383

  Fly   361 LFSPQVAARKLVTEPFEFANKNGRTVHLKPGDVVTIPV--KALHHDPQYYEDPLTFKPERFLESN 423
            |..|.:.....|.:.|.....     :..|.|.:.||.  .|| ||.:.|.:|.||.|:|: ..|
pombe   384 LRPPVLMVPYRVKKAFPITPD-----YTVPKDAMVIPTLYGAL-HDSKVYPEPETFNPDRW-APN 441

  Fly   424 GGGMKSYRDRGVYLAFGDGPRHCPGMRFALTQLKAAL--VEILRNFEIKVNPKTRSDNQIDDTFF 486
            |...:|.::   ::.||:||..|.|.|:|:..|.|.:  ..|:.:::.|..|.  ||.|:   .|
pombe   442 GLAEQSPKN---WMVFGNGPHVCLGQRYAVNHLIACIGKASIMLDWKHKRTPD--SDTQM---IF 498

  Fly   487 MATLKGGI-YLDF 498
            ..|....: ||.|
pombe   499 ATTFPQDMCYLKF 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	100/496 (20%)
erg5	NP_593788.2	CypX	57..505	CDD:225035	105/514 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
TreeFam	0	0.000	Not matched by this tool.
	3	3.050