DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	138/487 - (28%)
Similarity:	239/487 - (49%)	Gaps:	46/487 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDID-DIYEKYKDTDN 72
            :|:.|:|||:|::.|.....::|.||......||||:..:.    |:..::.| ..::||.|
  Rat    13 MLLATILVLLYLYGTSTHGNFKKLGISGPKPLPFVGNILAY----RHGFWEFDRHCHKKYGD--- 70

  Fly    73 MVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNF----VNKKTDMILGNNPFVLTGD-EW 132
            :.|.:..|.|.|.:..|:.|..:...:..|...|. |:|    :.||.        ..|:.| ||
  Rat    71 IWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNR-RSFGPAGILKKA--------ITLSEDEEW 126

  Fly   133 KERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGL 197
            |..|:.:.|..:..::|.::|:........|:.::.:.:....  :...|:...|:.:|::....
  Rat   127 KRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKGNP--ITMKDIFGAYSMDVITGTSF 189

  Fly   198 GVSAQSFTDTPTPLLKMIKRVFNTSF-EFIFYSVVT-NLWQKVRKFYSVPFFNKETEVFFLDIIR 260
            ||:..|..:...|.::.:|::...:| :..|.||:. .....|.:.:.:..|.|:...||...:.
  Rat   190 GVNVDSLNNPQNPFVQKVKKLLKFNFLDPFFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVE 254

  Fly   261 RCITLRLEKPEQQRDDFLNYMLQLQEK------KGLHTDNILINTMTFILDGFETTALVLAHIML 319
            |....|:::..:||.|||..|:..|..      :||....|:..::.||..|:|||:..|:..:.
  Rat   255 RMKENRMQEKVKQRLDFLQLMINSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALY 319

  Fly   320 MLGRNPEEQDKVRKEI-----GSADLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPFEFA 379
            :|..:|:.|.|::.||     ..|.:|:|.:.|:.:||..:.||||||.......::..:..|.
  Rat   320 LLATHPDLQKKLQDEIDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEI- 383

  Fly   380 NKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFGDGPR 444
              ||  |.:..|.||.:|..|||.||:.:.:|..|.||||.:.|...:..|    :||.||:|||
  Rat   384 --NG--VFIPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPY----IYLPFGNGPR 440

  Fly   445 HCPGMRFALTQLKAALVEILRNFEIKVNPKTR 476
            :|.||||||..:|.|||.:|:||...:..:|:
  Rat   441 NCIGMRFALMNMKIALVRVLQNFSFGLCKETQ 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	127/455 (28%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	128/461 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820