DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp28d2 and CYP3A5

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_000768.1	Gene:	CYP3A5 / 1577	HGNCID:	2638	Length:	502	Species:	Homo sapiens

Alignment Length:	503	Identity:	140/503 - (27%)
Similarity:	239/503 - (47%)	Gaps:	58/503 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VTTFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDID-DIYEKY 67
            |.|:|:|.:: |||:|::.|.....:::.||......|.:|:..|.    |...:..| :.|:||
Human     9 VETWLLLAVS-LVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY----RQGLWKFDTECYKKY 68

  Fly    68 KDTDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTG--- 129
               ..|.|.:..::|.|.:..|:.|..:...:..|.       |.|:::   ||...|:.:.
Human    69 ---GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSV-------FTNRRS---LGPVGFMKSAISL 120

  Fly   130 ---DEWKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEV 191
               :|||..||.:.|..:..::|.::|:........|..:||:.:  ..:.:...|:...|:.:|
Human   121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAE--KGKPVTLKDIFGAYSMDV 183

  Fly   192 VSDCGLGVSAQSFTDTPTPLLKMIKRVFNTSF------EFIFYSVVTNLWQKVRKFYSVPFFNKE 250
            ::....||:..|..:...|.::..|:.....|      ..|.:..:|.:::.:    :|..|.|:
Human   184 ITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEAL----NVSLFPKD 244

  Fly   251 TEVFFLDIIRRCITLRLEKPEQQRDDFLNYMLQLQEKKGLHTDNIL------INTMTFILDGFET 309
            |..|....:.|....||...::.|.|||..|:..|..|...:...|      ..::.||..|:||
Human   245 TINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309

  Fly   310 TALVLAHIMLMLGRNPEEQDKVRKEI-----GSADLTFDQMSELPHLDACIYETLRLFSPQVAAR 369
            |:.||:..:..|..:|:.|.|::|||     ..|..|:|.:.::.:||..:.||||||...:...
Human   310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLE 374

  Fly   370 KLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRG 434
            :...:..|.   ||  |.:..|.:|.||..||||||:|:.:|..|:||||.:.     |...|..
Human   375 RTCKKDVEI---NG--VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-----KDSIDPY 429

  Fly   435 VYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQID 482
            :|..||.|||:|.||||||..:|.||:.:|:||..|...:|:...::|
Human   430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	127/460 (28%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	129/472 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820