Protein Alignment Cyp28d2 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_608911.1
• Gene: Cyp28d2 / 33748
• FlyBaseID: FBgn0031688
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 139/489 - (28%)
• Similarity: 241/489 - (49%)
• Gaps: 41/489 - (8%)

  Fly     4 VTTFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYK 68
            |.|:|:|.:: |:|:|::.|.....::|.||......||:|:  ::..||....:|: :.|:||:
Human     9 VETWLLLAVS-LILLYLYGTRTHGLFKKLGIPGPTPLPFLGN--ALSFRKGYWTFDM-ECYKKYR 69

  Fly    69 DTDNMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILG---NNPFVLTGD 130
               .:.|::..:.|.|.:..|:.|..:...:..|.       |.|::....:|   |...:...:
Human    70 ---KVWGIYDCQQPMLAITDPDMIKTVLVKECYSV-------FTNRRPFGPVGFMKNAISIAEDE 124

  Fly   131 EWKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDC 195
            |||..||.:.|..:..::|.:.|:........|..:||:.:  |.:.:....:...|:.:|::..
Human   125 EWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE--TGKPVTLKHVFGAYSMDVITST 187

  Fly   196 GLGVSAQSFTDTPTPLLKMIKRV--FNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDI 258
            ..|||..|..:...|.::..|::  ||....|:....|......:.:..::..|.::...|....
Human   188 SFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKS 252

  Fly   259 IRRCITLRLEKPEQQRDDFLNYMLQLQEKKGLHTD------NILINTMTFILDGFETTALVLAHI 317
            :::....||::.::.|.|||..|:..|..|...|.      .::..::.||..|:|||:.||:.|
Human   253 VKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFI 317

  Fly   318 MLMLGRNPEEQDKVRKEI-----GSADLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPFE 377
            :..|..:|:.|.||:|||     ..|..|:|.:.:|.:||..:.||||||...:...::..:..|
Human   318 IYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVE 382

  Fly   378 FANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFGDG 442
            .   ||  :.:..|.||.||...|||||:|:.:|..|.||||.:.|...:..|    :|..||.|
Human   383 I---NG--MFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPY----IYTPFGSG 438

  Fly   443 PRHCPGMRFALTQLKAALVEILRNFEIKVNPKTR 476
            ||:|.||||||..:|.|||.:|:||..|...:|:
Human   439 PRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQ 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	CYP6-like	74..495	CDD:410679	119/419 (28%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	121/427 (28%)