Protein Alignment Cyp28d2 and CYP3A7-CYP3A51P

DIOPT Version :10

• Sequence 1: NP_608911.1
• Gene: Cyp28d2 / 33748
• FlyBaseID: FBgn0031688
• Length: 501
• Species: Drosophila melanogaster
• Sequence 2: NP_001243426.2
• Gene: CYP3A7-CYP3A51P / 100861540
• HGNCID: 51504
• Length: 535
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 87/497 - (17%)
• Similarity: 181/497 - (36%)
• Gaps: 141/497 - (28%)

  Fly     5 GSATLPFNTAGATVEETLNQIQEYIKL--------TTNLISSVQ--------IDNVSGVGRRQQR 53
            |.|.:||.|...:         |::::        ..::.:..:        ||.:..:||::.|
Human   229 GEANVPFITVNGS---------EFLEMFVGVGPARVRDMFAMARKHAPCILFIDEIDAIGRKRGR 284

  Fly    54 QRSMGDESCYFVPINSATLE-DVRHSDTEVRLSLNGGPRPQSVQSIST-----NQSTTPVPPSAS 112
            .. :|.:|.....:|...:| |..:|.|.| :.|.|..||..:....|     ::.....||...
Human   285 GH-LGGQSEQENTLNQMLVEMDGFNSSTNV-VVLAGTNRPDILDPALTRPGRFDRQIYIGPPDIK 347

  Fly   113 CDELRYRMETQ------SKNMQALKEQQAHLLR----------LQQAARQQLQEMESIRHMHSAS 161
            .....:::..:      |.:..||..:.|.|..          ..:||      :.:.||:
Human   348 GRSSIFKVHLRPLKLDGSLSKDALSRKLAALTPGFTGADISNVCNEAA------LIAARHL---- 402

  Fly   162 VAPPIESFQTVEQVQDGIGSIMERMRVL----STFIQNQQELSNMLG--PEHDADVMADQVILQQ 220
             :|.::.....:.::..||.:.::.:||    .|.:...:....::|  .||...::...:|.:.
Human   403 -SPSVQERHFEQAIERVIGGLEKKTQVLQPSEKTTVAYHEAGHAVVGWFLEHADPLLKVSIIPRG 466

  Fly   221 K---FAELRDKKSQMHNLVSELQNLNMDANRQFDGEAAAVPAEPRNVPIELTHAPAPASDARNAT 282
            |   :|:...::..::.           ..:.||.....:                   ..|.|.
Human   467 KGLGYAQYLPREQFLYT-----------REQLFDRMCMML-------------------GGRVAE 501

  Fly   283 KIFLNGGGSTMEGTSGGLNPVATVEGMSVPAHRQLGEEQRANGHMA------SSAAVDEEDDE-- 339
            ::|..      :.|:|..:.:..|...:.....|.|..::. |.::      ....|::...|
Human   502 QLFFG------QITTGAQDDLRKVTQSAYAQIVQFGMSEKL-GQVSFDFPRQGETMVEKPYSEAT 559

  Fly   340 GQLNEEEA-----SVLNGTADMLS---EKINEINAMKSQLRRL--KEMMDTVKLIEM-------- 386
            .||.:||.     |..|.|.::|:   |::.::.      |||  ||:::...:||:
Human   560 AQLIDEEVRCLVRSAYNRTLELLTQCREQVEKVG------RRLLEKEVLEKADMIELLGPRPFAE 618

  Fly   387 KTGHESIDE---EEEDEEDAPEDEEEGDDEEEEGATAIAMQQ 425
            |:.:|...|   ..|::...||..::.:...|||.|...:|:
Human   619 KSTYEEFVEGTGSLEEDTSLPEGLKDWNKGREEGGTERGLQE 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	CYP6-like	74..495	CDD:410679	72/411 (18%)
CYP3A7-CYP3A51P	NP_001243426.2	CYP3A	67..492	CDD:410743	49/295 (17%)