DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp28d2 and Cyp3a59

DIOPT Version :9

Sequence 1:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster
Sequence 2:	NP_001098630.1	Gene:	Cyp3a59 / 100041449	MGIID:	3769707	Length:	503	Species:	Mus musculus

Alignment Length:	487	Identity:	128/487 - (26%)
Similarity:	236/487 - (48%)	Gaps:	46/487 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYDIDDIYEKYKDTDNM 73
            ||::|.||..|::.|::...::|.||......|..|:..:.|.....  :| :|.|:||   ..:
Mouse    13 VLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFDGMWK--FD-EDCYKKY---GKI 71

  Fly    74 VGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPF------VLTGDEW 132
            .|.:....|.|.:|.||.|..:...:..|.       |.|:.|   ||...|      :...:||
Mouse    72 WGFYVGPKPILAIMDPEIIKIVLVKECYSV-------FTNRPT---LGPVGFLKKSITISEDEEW 126

  Fly   133 KERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEGLDAMDLSLCYTTEVVSDCGL 197
            |..|:.:.|..:..::|.::|:.:......|..:||:::  ..|.::..|:...|:.:|::....
Mouse   127 KRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEE--KGEPINMKDIFGAYSMDVITGTSF 189

  Fly   198 GVSAQSFTDTPTPLLKMIKRV--FNTSFEFIFYSVVTNLWQKVRKFYSVPFFNKETEVFFLDIIR 260
            ||:..|..:...|.::..|::  |.....|:..:::......:.:..::..|.:::..||...::
Mouse   190 GVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLSTILFPFLTPIYEMLNLSIFPRDSMNFFKKFVK 254

  Fly   261 RCITLRLEKPEQQRDDFLNYMLQLQEKKGLHTDNIL------INTMTFILDGFETTALVLAHIML 319
            |....||...::.|.|||..|:..|..||..:...|      ...:.||..|::.|:..::.||.
Mouse   255 RMKKERLASKQKNRVDFLQLMMNTQNSKGQESQKALSDLEMAAQAVIFIFGGYDATSTSISLIMY 319

  Fly   320 MLGRNPEEQDKVRKEI-----GSADLTFDQMSELPHLDACIYETLRLFSPQVAARKLVTEPFEFA 379
            .|..:|:.|.|::.||     ..|.:|:|.:.::.:||..:.|:|||:...:...::..:..|.
Mouse   320 ELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEI- 383

  Fly   380 NKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMKSYRDRGVYLAFGDGPR 444
              ||  |.:..|.||.||:..||.:|:|:.:|..|.|.||.:.|.|.:..|    :|:.||:|||
Mouse   384 --NG--VFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPGRFSKENEGNIDPY----IYMPFGNGPR 440

  Fly   445 HCPGMRFALTQLKAALVEILRNFEIKVNPKTR 476
            :|..|||||..:|.|::.:|:||.::...:|:
Mouse   441 NCLDMRFALISMKLAVIGVLQNFTVQPCEETQ 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	117/455 (26%)
Cyp3a59	NP_001098630.1	p450	39..493	CDD:278495	118/461 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820