DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn11 and RPN11

DIOPT Version :9

Sequence 1:	NP_608905.1	Gene:	Rpn11 / 33738	FlyBaseID:	FBgn0028694	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_116659.1	Gene:	RPN11 / 850554	SGDID:	S000001900	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	308	Identity:	198/308 - (64%)
Similarity:	238/308 - (77%)	Gaps:	2/308 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDRLLRLGGAMPQAAPPTDAPVVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTV 65
            |:||.||  .|.......|....||.|.|||||:|||||||||||||||||||||||||||||||
Yeast     1 MERLQRL--MMNSKVGSADTGRDDTKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTV 63

  Fly    66 QVIDVFAMPQTGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQS 130
            .|:|||||||:||||||||||.||||||:||||||||.:|||||||||||||||||.||:|||:|
Yeast    64 NVVDVFAMPQSGTGVSVEAVDDVFQAKMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKS 128

  Fly   131 FEALSERAVAVVVDPIQSVKGKVVIDAFRLINPNMLVLGQEPRQTTSNLGHLQKPSVQALIHGLN 195
            ||.|:.|||||||||||||||||||||||||:...|:...||||||||.|.|.|.::||||||||
Yeast   129 FEQLNSRAVAVVVDPIQSVKGKVVIDAFRLIDTGALINNLEPRQTTSNTGLLNKANIQALIHGLN 193

  Fly   196 RHYYSISINYRKNELEQKMLLNLHKKSWKDGLTLSDYNEHCSINEDTVAEMLDLAKNYNKSLEDE 260
            |||||::|:|.|...|.|||:||||:.|:.||.:.||.|....|......|:.:|:.|:|.:|:|
Yeast   194 RHYYSLNIDYHKTAKETKMLMNLHKEQWQSGLKMYDYEEKEESNLAATKSMVKIAEQYSKRIEEE 258

  Fly   261 EKMTPEQLAIKNVGKQDPKRHLEEKVDKVMQNNIVQCLGAMLDTIVFK 308
            :::|.|:|..:.||:||||:||.|..|:.::||||..|.|.::::..|
Yeast   259 KELTEEELKTRYVGRQDPKKHLSETADETLENNIVSVLTAGVNSVAIK 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn11	NP_608905.1	MPN_RPN11_CSN5	19..284	CDD:163700	183/264 (69%)
RPN11	NP_116659.1	MPN_RPN11_CSN5	22..282	CDD:163700	182/259 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344010
Domainoid	1	1.000	201	1.000	Domainoid score	I559
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4240
Inparanoid	1	1.050	394	1.000	Inparanoid score	I321
Isobase	1	0.950	-	0.802101	Normalized mean entropy	S108
OMA	1	1.010	-	-		QHG53757
OrthoFinder	1	1.000	-	-		FOG0004641
OrthoInspector	1	1.000	-	-		oto99983
orthoMCL	1	0.900	-	-		OOG6_101835
Panther	1	1.100	-	-	LDO	PTHR10410
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1200
SonicParanoid	1	1.000	-	-		X3258
TreeFam	1	0.960	-	-
	16	15.740