DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn11 and Mpnd

DIOPT Version :9

Sequence 1:	NP_608905.1	Gene:	Rpn11 / 33738	FlyBaseID:	FBgn0028694	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_080806.4	Gene:	Mpnd / 68047	MGIID:	1915297	Length:	487	Species:	Mus musculus

Alignment Length:	346	Identity:	71/346 - (20%)
Similarity:	117/346 - (33%)	Gaps:	127/346 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GGAMPQAAPP----TDAPVV---------DTAEQ----VYISSLALLKMLKHGRAGVP------- 48
            |...|:|.||    ...||.         |:|..    |.::|.|.:...:.....|.
Mouse   204 GSLEPEATPPGKRMDKVPVPIRYCMLGSRDSARNPHTLVEVTSFAAINKFQPFNVAVSSNVLFLL 268

  Fly    49 --------MEVMGLMLGEFVDDYTVQVIDVF-AMP------QTGTGVSVEAVDPVFQAKMLDMLK 98
                    .||:|.:.|.:  |...|::.|. |.|      .|.|..:||  :.::|...|
Mouse   269 DFHCHLTRSEVVGYLGGRW--DINNQMLTVLRAFPCRSRLGDTDTAATVE--EEIYQVLFL---- 325

  Fly    99 QTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERA-------VAVVVDPIQS----VKGK 152
               |...:||||||||......|..||:.|..::...:.:       :|::..|..|    .:.|
Mouse   326 ---RGLSLVGWYHSHPHSPAVPSLQDIDAQMEYQLRLQGSSNGFQPCLALLCSPYYSGNPGPESK 387

  Fly   153 VVIDAFRLINPNMLVLGQEPRQTTSNLGHLQKPSVQALIHGLNRHYYSISINYRKNELEQKMLLN 217
            :.  .|.::.|        |.|..|:                    |.|.::.....::...|.|
Mouse   388 IC--PFWVMPP--------PEQRPSD--------------------YGIPMDVEMAYVQDSFLTN 422

  Fly   218 LHKKSWKDGLTLSDYNEHCSINEDTVAEMLDLAKNYNKSLED----EEKMTPEQLAI----KNVG 274
                                   |.:.||:.||:.| |...|    :|..:||...:    .::.
Mouse   423 -----------------------DVLQEMVMLAEFY-KGAPDLVKFQEAWSPEHTYLDKLKMSLA 463

  Fly   275 KQDPKR----HLEEKVDKVMQ 291
            .:.||.    |:.|:|..|::
Mouse   464 SRTPKDQGMCHVLEQVCSVLK 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn11	NP_608905.1	MPN_RPN11_CSN5	19..284	CDD:163700	63/322 (20%)
Mpnd	NP_080806.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..217		5/12 (42%)
		MPN_2A_DUB	252..436	CDD:163698	48/248 (19%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	335..348		5/12 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810