DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn11 and MYSM1

DIOPT Version :9

Sequence 1:	NP_608905.1	Gene:	Rpn11 / 33738	FlyBaseID:	FBgn0028694	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_001078956.1	Gene:	MYSM1 / 114803	HGNCID:	29401	Length:	828	Species:	Homo sapiens

Alignment Length:	276	Identity:	77/276 - (27%)
Similarity:	118/276 - (42%)	Gaps:	59/276 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVD-DYTVQVIDVFAMPQTGTGVSVEAVDPVFQA 91
            ||.::|.|||.|..|....: .||:||:.|.:.: |..|:|..........||:..| :|||.|.
Human   576 QVKVASEALLIMDLHAHVSM-AEVIGLLGGRYSEVDKVVEVCAAEPCNSLSTGLQCE-MDPVSQT 638

  Fly    92 KMLDMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVID 156
            :..:.|...|  ..|:|||||||.|....|..||:||..:::...|..|..:.        :::.
Human   639 QASETLAVRG--FSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKFIG--------MIVS 693

  Fly   157 AFRLINP------NMLVLGQEPRQTTSNLGHLQKP---SVQALIH----GL---------NRHYY 199
            .:...||      ..||:.:|    .|..|..:.|   .||.::.    ||         .::..
Human   694 PYNRNNPLPYSQITCLVISEE----ISPDGSYRLPYKFEVQQMLEEPQWGLVFEKTRWIIEKYRL 754

  Fly   200 SIS------INYRKNELE--QKMLLNLHKKSWKDGLTLSDYNEHCSINEDTVAEMLDL-AKNYNK 255
            |.|      |..|.::|.  ||:|..:.|       |||... :|.:.|:.:.|:.:| ..||..
Human   755 SHSSVPMDKIFRRDSDLTCLQKLLECMRK-------TLSKVT-NCFMAEEFLTEIENLFLSNYKS 811

  Fly   256 SLED---EEKMTPEQL 268
            :.|:   ||..|.|.|
Human   812 NQENGVTEENCTKELL 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn11	NP_608905.1	MPN_RPN11_CSN5	19..284	CDD:163700	77/276 (28%)
MYSM1	NP_001078956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		SANT	120..164	CDD:197842
		Myb_DNA-binding	120..162	CDD:278669
		SWIRM	382..461	CDD:282311
		MPN_2A_DUB	571..753	CDD:163698	53/192 (28%)
		JAMM motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01182	656..669		6/12 (50%)
		LXXLL motif	774..778		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810