DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpn11 and COPS6

DIOPT Version :9

Sequence 1:	NP_608905.1	Gene:	Rpn11 / 33738	FlyBaseID:	FBgn0028694	Length:	308	Species:	Drosophila melanogaster
Sequence 2:	NP_006824.2	Gene:	COPS6 / 10980	HGNCID:	21749	Length:	327	Species:	Homo sapiens

Alignment Length:	217	Identity:	52/217 - (23%)
Similarity:	82/217 - (37%)	Gaps:	53/217 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VIDVFAMPQTGTGVSVEAVDPVFQAKMLD----MLKQTGRPEMVVGWYHSHPGFGCWLSGVDINT 127
            |..|.|...||: ||| |:.|:....:.|    |..|.|||..|:|......      .|.:|..
Human    27 VPSVMACGVTGS-VSV-ALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQ------EGRNIEV 83

  Fly   128 QQSFEALSERAVAVVVDPIQSVKGKVVID---------AFRLINPNMLVLGQEPRQTTSNLGHLQ 183
            ..|||.||           .:|:.|::||         .|:.:...:..||.   .||..
Human    84 MNSFELLS-----------HTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGW---YTTGG----- 129

  Fly   184 KPSVQALIHGLNRHYYSISINYRKNELEQKMLLNLHKKSWKDGLTLSDYNEHCS-INEDTVAEML 247
             |...:.|| :::....|        :|..:.|.|:..:....|.:|.:..... ||.:  |.||
Human   130 -PPDPSDIH-VHKQVCEI--------IESPLFLKLNPMTKHTDLPVSVFESVIDIINGE--ATML 182

  Fly   248 DLAKNYNKSLEDEEKMTPEQLA 269
            .....|..:.|:.|::..:.:|
Human   183 FAELTYTLATEEAERIGVDHVA 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpn11	NP_608905.1	MPN_RPN11_CSN5	19..284	CDD:163700	52/217 (24%)
COPS6	NP_006824.2	MPN_CSN6	39..321	CDD:163694	47/204 (23%)
COPS6	NP_006824.2	Interaction with Vpr	211..327
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1310
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810