DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9121 and ASB16

DIOPT Version :9

Sequence 1:	NP_608901.1	Gene:	CG9121 / 33732	FlyBaseID:	FBgn0031675	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_543139.4	Gene:	ASB16 / 92591	HGNCID:	19768	Length:	453	Species:	Homo sapiens

Alignment Length:	547	Identity:	128/547 - (23%)
Similarity:	176/547 - (32%)	Gaps:	193/547 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TCGRTAVGTAAILGDAELLELLLQSCEEPELNVFHQSNTDSLEIERTPEGMEKLEWVDEFENSAE 102
            :|...||..|...|:.:.::.|.|..|...:.|...||              :|.|      |||
Human    55 SCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSN--------------QLAW------SAE 99

  Fly   103 NGAGSGEEDSQLYQYYAKTFETTGEFISSQCCVSCREHDPHLYDADVATPLHYAAYWGHEECVRI 167
            .|         .:....||.:|                          .||..|...|:.:|.|.
Human   100 QG---------FWVLTPKTKQT--------------------------APLAIATARGYTDCARH 129

  Fly   168 LLEHNAPINVLNNDGYAPLHLGAGFA--GVTELLIKHGALVNAKTLSDGKTALHMAIESKCAESA 230
            |:...|.::. ...|.|.||.....|  ....||:..||..|..| .:|.|.||:....:..:.|
Human   130 LIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVLT-EEGTTPLHLCTIPESLQCA 192

  Fly   231 RLLLQTNININ-DTDDDGETPLMAAIACSMLDVAEELVKRGARINIQDKQNHTALQYAVRG---- 290
            :|||:....:| ...:..||||..|.|..:.......::.||.:.::..|..|||..|..|
Human   193 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGP 257

  Fly   291 ----RHTQMAKLLLERGARRLAS---QHL-LHLAVESNVKELVELLLQYGESLSVWNLKNFTPIM 347
                ||...|:.|||.||...|:   :|. ||.|..:....|.||||:||....|.|....||:.
Human   258 GSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMD 322

  Fly   348 LAIHRGRHEMLEYLLNVAEEQRKLGLYSDVHD----EGLVLFAVQQNFWVK-----------EFS 397
            .|:..                        |.|    |..||||...::..:           .|.
Human   323 CALQA------------------------VQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCANFP 363

  Fly   398 RILRVLLAKSPSARNDFYDSCAPTIVCGLIYCHTPLSRAINLHRLEVAEFLIHEGCNLAQICREH 462
            |.|.|||...|         |.|:       |.|.:...
Human   364 RALEVLLNAYP---------CVPS-------CETWVEAV-------------------------- 386

  Fly   463 VVNELRSNCTPTRLAFARLLCNAGFQFPHKHRPLPKDWPPARLEFEREMCLLGTQPRSLQSLARL 527
                                             ||:.|......:...:|:: .|||.||.||||
Human   387 ---------------------------------LPELWKEHEAFYSSALCMV-NQPRQLQHLARL 417

  Fly   528 EIRRSL-LRCLQ--TR---PEVQERYL 548
            .:|..| .||.|  ||   |.:...||
Human   418 AVRARLGSRCRQGATRLPLPPLLRDYL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9121	NP_608901.1	ANK	151..300	CDD:238125	45/159 (28%)
		ANK repeat	151..179	CDD:293786	8/27 (30%)
		Ank_2	153..244	CDD:289560	27/93 (29%)
		ANK repeat	181..210	CDD:293786	10/30 (33%)
		ANK repeat	213..244	CDD:293786	9/31 (29%)
		Ank_2	218..304	CDD:289560	27/94 (29%)
		ANK	241..362	CDD:238125	40/133 (30%)
		ANK repeat	246..277	CDD:293786	8/30 (27%)
		ANK repeat	279..304	CDD:293786	12/32 (38%)
		Ank_4	311..362	CDD:290365	16/51 (31%)
		SOCS_box	518..574	CDD:284857	18/37 (49%)
ASB16	NP_543139.4	ankyrin repeat 1	56..85		8/28 (29%)
		Ank_2	62..171	CDD:289560	34/164 (21%)
		ankyrin repeat 2	110..139		9/54 (17%)
		ANK	114..228	CDD:238125	34/115 (30%)
		ANK repeat	114..140	CDD:293786	8/26 (31%)
		ankyrin repeat 3	142..171		9/28 (32%)
		ANK repeat	143..173	CDD:293786	10/29 (34%)
		Ank_2	147..239	CDD:289560	26/92 (28%)
		ANK repeat	175..207	CDD:293786	9/31 (29%)
		ankyrin repeat 4	175..204		8/28 (29%)
		ANK repeat	209..239	CDD:293786	8/29 (28%)
		ankyrin repeat 5	209..238		8/28 (29%)
		Ank_2	214..308	CDD:289560	30/93 (32%)
		ANK repeat	242..314	CDD:293786	27/71 (38%)
		ankyrin repeat 6	242..279		14/36 (39%)
		ankyrin repeat 7	283..312		11/28 (39%)
		ANK	285..>350	CDD:238125	23/88 (26%)
		ANK repeat	316..348	CDD:293786	10/55 (18%)
		SOCS box domain	398..450		20/48 (42%)
		SOCS_ASB_like	406..447	CDD:239686	19/39 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4955
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050