Protein Alignment CG9121 and ASB3

DIOPT Version :10

• Sequence 1: NP_608901.1
• Gene: CG9121 / 33732
• FlyBaseID: FBgn0031675
• Length: 600
• Species: Drosophila melanogaster
• Sequence 2: NP_057199.1
• Gene: ASB3 / 51130
• HGNCID: 16013
• Length: 518
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 147/633 - (23%)
• Similarity: 221/633 - (34%)
• Gaps: 182/633 - (28%)

  Fly    18 DFEQALGCIMQGAQASYVSPTCGRTAVGTAAILGDAELLELLLQSCEEPELNVFHQSNTDSLEIE 82
            ||.:|            .:.||  :.||.||..|:.::|..||:.                   .
Human     2 DFTEA------------YADTC--STVGLAAREGNVKVLRKLLKK-------------------G 33

  Fly    83 RTPEGMEKLEWVD----EFENSAE-----NGAGSGEEDSQLYQYYAKTFETTGEFISSQCCVSCR 138
            |:.:..:...|:.    .:.||.|     ..|.|.|...::     ||||       ..|.
Human    34 RSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKM-----KTFE-------GFCA---- 82

  Fly   139 EHDPHLYDADVATPLHYAAYWGHEECVRILLEHNAPINVLNNDGYAPLHLGA--GFAGVTELLIK 201
                          ||.||..||.:.|:||||..|..|....:...||.|..  |...|..||::
Human    83 --------------LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133

  Fly   202 HGALVNAKTLSDGKTALHMAIESKCAESARLLLQTNININDTDDDGETPLMAAIACSMLDVAEEL 266
            |||.||......|..:||.|...:.||..:|||:...|....||.|.|||..|.....|:....|
Human   134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 198

  Fly   267 VKRGARINIQDKQNHTALQYAVRGRHTQMAKLLLERGA------RRLASQHLLHLAVESNVKELV 325
            :..||.:|.|.....|.|..|.:..||:..:|||..||      ...:.|..:|.|.:....:::
Human   199 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKIL 263

  Fly   326 ELLLQYGESLSVWNLKNFTPIMLAIHRGRHEMLEYLLN-----VAEEQRKLGLYSDVHDEGLVLF 385
            :||:..........|...:|:..|:..|..:.||.||.     .|:.....|..|.      |..
Human   264 DLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSP------VCM 322

  Fly   386 AVQQNFWVKEFSRILRVLLAKSPSARNDFYDSCAPTIVCGLIYCHTPLSRAINLHRLEVAEFLIH 450
            |.|::.   ||..|:.:|| |..:..|:.:          |.||       :...:..:..:.:.
Human   323 AFQKDC---EFFGIVNILL-KYGAQINELH----------LAYC-------LKYEKFSIFRYFLR 366

  Fly   451 EGCNLAQICREHVVNELRSNCTPTRLAFAR--------------LLCNA------------GFQF 489
            :||:|..  ..|:. |..::....:..:..              ||||:            ..:|
Human   367 KGCSLGP--WNHIY-EFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEF 428

  Fly   490 PHKHRPLPKDWPPARLEFEREMCL-----------LGTQPRSLQSLARLEIRRSLLRCLQTRPEV 543
                    .:|.......||.:..           :.|.| ||..|.|||||.||
Human   429 --------TNWKTLAPAVERMLSARASNAWILQQHIATVP-SLTHLCRLEIRSSL---------- 474

  Fly   544 QERYLPTQERSSLGRIVDEFAIPATLKRYLSDFD-----ELPPVRGME 586
                  ..||......:.:..:|.:|..||...|     |:|.:..::
Human   475 ------KSERLRSDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQ 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9121	NP_608901.1	ANKYR	141..362	CDD:440430	69/228 (30%)
		ANK repeat	151..179	CDD:293786	13/27 (48%)
		ANK repeat	181..210	CDD:293786	12/30 (40%)
		ANK repeat	213..244	CDD:293786	10/30 (33%)
		ANK repeat	246..277	CDD:293786	10/30 (33%)
		ANK repeat	279..304	CDD:293786	8/24 (33%)
		SOCS_box	517..573	CDD:462192	15/55 (27%)
ASB3	NP_057199.1	ANK 1	9..38		11/49 (22%)
		ANKYR	16..269	CDD:440430	82/301 (27%)
		ANK repeat	42..76	CDD:293786	7/38 (18%)
		ANK 2	42..71		7/28 (25%)
		ANK repeat	78..109	CDD:293786	15/55 (27%)
		ANK 3	78..107		14/53 (26%)
		ANK 4	111..140		11/28 (39%)
		ANK repeat	111..139	CDD:293786	10/27 (37%)
		ANK 5	145..174		10/28 (36%)
		ANK repeat	146..176	CDD:293786	10/29 (34%)
		ANK repeat	178..209	CDD:293786	10/30 (33%)
		ANK 6	178..207		9/28 (32%)
		ANKYR	192..>368	CDD:440430	45/202 (22%)
		ANK repeat	211..240	CDD:293786	10/28 (36%)
		ANK 7	211..240		10/28 (36%)
		ANK repeat	245..279	CDD:293786	5/33 (15%)
		ANK 8	246..275		5/28 (18%)
		ANK 9	279..308		7/28 (25%)
		ANK repeat	281..309	CDD:293786	7/27 (26%)
		ANK repeat	314..346	CDD:293786	11/41 (27%)
		ANK 10	315..346		11/40 (28%)
		ANK 11	348..373		6/41 (15%)
		SOCS_ASB3	457..507	CDD:239692	19/66 (29%)