DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9121 and ASB18

DIOPT Version :9

Sequence 1:	NP_608901.1	Gene:	CG9121 / 33732	FlyBaseID:	FBgn0031675	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_997721.2	Gene:	ASB18 / 401036	HGNCID:	19770	Length:	466	Species:	Homo sapiens

Alignment Length:	607	Identity:	136/607 - (22%)
Similarity:	216/607 - (35%)	Gaps:	196/607 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LSYDLNERLLTAVQSGDFEQA----------LGCIMQGAQASYVSPTCGRTAVGTAAILGDAELL 56
            |:.||.:||.:|:.:.|.|:.          :..:::.|...::.....:  :.|..:|||.:.|
Human    12 LNSDLVKRLKSALDAKDEERVRDLICTEITPVDAVIELANDDWMKDPSAQ--LPTGMLLGDLDHL 74

  Fly    57 ELLLQSCEEPELNVFHQSNTDSLEIERTPEGMEKLEWVDEFENSAENGAGSGEEDSQLYQYYAKT 121
                    :|.::.|.|......||.:     :::||  :.::.|..|.      |.|:     |
Human    75 --------KPLMDQFFQDANVVFEINK-----DEMEW--QVKSPATFGL------SGLW-----T 113

  Fly   122 FETTGEFISSQCCVSCREHDP---HLY----DADVATP-----LHYAAYWGHEECVRILLEHNAP 174
            .|...|..:..|..:...|..   ||.    |.| |:|     ||.|...||..|||:||:|.|.
Human   114 LEYKRELTTPLCIAAAHGHTACVRHLLGRGADPD-ASPGGRGALHEACLGGHTACVRLLLQHRAD 177

  Fly   175 INVLNNDGYAPLHL--GAGFAGVTELLIKHGALVNAKTLSDGKTALHMAIESKCAESARLLLQTN 237
            .::|:.:|.|||||  .|...|..:.|::|||.|.....:...|.||:|.:....|.|||.|...
Human   178 PDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLDEHARLYLGRG 242

  Fly   238 ININDTDDDGETPLMAAIACS--------MLDVAEELVKRGARINIQDKQNHTALQYAVRGRHTQ 294
            .:::..:..|||.|.||...:        .|.:...|::|||..:.:|:...:.|..|.......
Human   243 AHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDEDERSPLHKACGHASHS 307

  Fly   295 MAKLLLERGARRLASQHLLHLAVESNVKELVELLLQYGESLSVWNLKNFTPIMLAIHRGRHEMLE 359
            :|:|||..||...|                    |.||.:..:..:  ......|:.......::
Human   308 LARLLLRHGADAGA--------------------LDYGGASPLGRV--LQTASCALQASPQRTVQ 350

  Fly   360 YLLNVAEEQRKLGLYSDVHDEGLVLFAVQQNFWVKEFSRILRVLLAKSPSARNDFYDSCA--PTI 422
            .|||              |....|        |...|.::|:               :||  |.:
Human   351 ALLN--------------HGSPTV--------WPDAFPKVLK---------------TCASVPAV 378

  Fly   423 VCGLIYCHTPLSRAINLHRLEVAEFLIHEGCNLAQICREHVVNELRSNCTPTRLAFARLLCNAGF 487
            :                      |.|.:   :..|:|    ::|......|..:          |
Human   379 I----------------------EVLFN---SYPQLC----LSESWKEVIPEEV----------F 404

  Fly   488 QFPHKHRPLPKDWPPARLEFEREMCLLGTQPRSLQSLARLEIRRSL-LRCLQTRPEVQERYLPTQ 551
            |.   |:|           |.:.:..|...||.||.|.|..:||.. .||....|     .||
Human   405 QM---HKP-----------FYQSLFALALTPRCLQHLCRCALRRLFGKRCFDLIP-----LLP-- 448

  Fly   552 ERSSLGRIVDEFAIPATLKRYL 573
                         :|..|:.||
Human   449 -------------LPKPLQNYL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9121	NP_608901.1	ANK	151..300	CDD:238125	52/163 (32%)
		ANK repeat	151..179	CDD:293786	13/32 (41%)
		Ank_2	153..244	CDD:289560	35/92 (38%)
		ANK repeat	181..210	CDD:293786	13/30 (43%)
		ANK repeat	213..244	CDD:293786	9/30 (30%)
		Ank_2	218..304	CDD:289560	26/93 (28%)
		ANK	241..362	CDD:238125	25/128 (20%)
		ANK repeat	246..277	CDD:293786	11/38 (29%)
		ANK repeat	279..304	CDD:293786	6/24 (25%)
		Ank_4	311..362	CDD:290365	4/50 (8%)
		SOCS_box	518..574	CDD:284857	17/57 (30%)
ASB18	NP_997721.2	ANK 1	119..148		7/29 (24%)
		ANK	122..237	CDD:238125	40/115 (35%)
		ANK repeat	122..149	CDD:293786	6/27 (22%)
		Ank_2	124..214	CDD:289560	34/90 (38%)
		ANK repeat	151..182	CDD:293786	12/30 (40%)
		ANK 2	151..180		12/28 (43%)
		ANK repeat	184..214	CDD:293786	13/29 (45%)
		ANK 3	184..213		13/28 (46%)
		ANK repeat	217..249	CDD:293786	9/31 (29%)
		ANK 4	218..247		9/28 (32%)
		ANK	221..330	CDD:238125	33/128 (26%)
		Ank_2	223..323	CDD:289560	29/119 (24%)
		ANK repeat	251..290	CDD:293786	11/38 (29%)
		ANK 5	251..288		11/36 (31%)
		ANK repeat	292..323	CDD:293786	9/50 (18%)
		ANK 6	292..321		8/28 (29%)
		ANK repeat	325..356	CDD:293786	5/46 (11%)
		SOCS_ASB4_ASB18	420..466	CDD:239693	17/58 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156767
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I4955
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.980