DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9121 and Asb18

DIOPT Version :9

Sequence 1:	NP_608901.1	Gene:	CG9121 / 33732	FlyBaseID:	FBgn0031675	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001101701.1	Gene:	Asb18 / 316614	RGDID:	1310850	Length:	467	Species:	Rattus norvegicus

Alignment Length:	617	Identity:	132/617 - (21%)
Similarity:	212/617 - (34%)	Gaps:	215/617 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LSYDLNERLLTAVQSGDFE--QALGC--------IMQGAQASYVSPTCGRTAVGTAAILGDAELL 56
            ||.||..||.:|:.:||.:  |.|.|        :::.|...::.....:  :.|.|:|||.:.:
  Rat    12 LSSDLVRRLKSALATGDRDTVQELICTEVEPVDAVLELANDDWMKEPSAK--LPTGALLGDLDHI 74

  Fly    57 ELLLQSCEEPELNVFHQSNTDSLEIERTP------EGMEKLEWVDEFENSAENGAGSGEEDSQLY 115
            :.|...|.. :.||..:.:|:.:|.:.|.      .|:..||:..|........|..|.|.
  Rat    75 QSLTDQCFW-DANVVFEISTEEMEWQVTSLATFGLSGLWTLEYKRELTTPLCIAAAHGHES---- 134

  Fly   116 QYYAKTFETTGEFISSQCCVS---CREHDPHLYDADVATP-----LHYAAYWGHEECVRILLEHN 172
                              ||.   .|:.||.      |:|     ||.|....|..|.|:||:|.
  Rat   135 ------------------CVRHLLSRKADPD------ASPGGRGALHEACLGSHTACARLLLQHG 175

  Fly   173 APINVLNNDGYAPLHL--GAGFAGVTELLIKHGALVNAKTLSDGKTALHMAIESKCAESARLLLQ 235
            |..::|:::|.|||||  .....|..:.|::|||.|..:...:..|.||:|.:....:.|:|.|.
  Rat   176 ADPDLLSSEGLAPLHLCRTPASLGCAQELLEHGATVQLEGGPNRDTPLHVAAQRGLDKHAQLYLG 240

  Fly   236 TNININDTDDDGETPLMAAIACSMLDVAEE---------LVKRGARINIQDKQNHTALQYAVRGR 291
            ....::..:..|||.|.||...:.....|.         |::.||..:::|:...:.|..|....
  Rat   241 CGARVDARNGRGETALSAACGAAARSPEEHARCLRLCALLLRGGAATDMRDEDERSPLHKACGHA 305

  Fly   292 HTQMAKLLLERGARRLASQHLLHLAVESNVKELVELLLQYGESLSVWNLKNFTPIMLAIHRGR-- 354
            ...:..|||..||...|                    |.||.:         :|:..|:....
  Rat   306 RPGLCTLLLRNGADADA--------------------LDYGGA---------SPLARALQTATCA 341

  Fly   355 -----HEMLEYLLNVAEEQRKLGLYSDVHDEGLVLFAVQQNFWVKEFSRILRVLLAKSPSARNDF 414
                 ...::.|||              |.        .::.|...|.::||
  Rat   342 PPTAPQRTVQALLN--------------HG--------SRSVWPDAFPKVLR------------- 371

  Fly   415 YDSCA--PTIVCGLIYCHTPLSRAINLHRLEVAEFLIHEGCNLAQICREHVVNELRSNCTPTRLA 477
              :||  |.::..|...:|.|                    .:::..||.:..|:
  Rat   372 --TCAPVPAVIEVLFNSYTQL--------------------RVSESWREAIPEEV---------- 404

  Fly   478 FARLLCNAGFQFPHKHRPLPKDWPPARLEFEREMCLLGTQPRSLQSLARLEIRRSL-LRCLQTRP 541
                     :|.   |:|           |.|.:..|...||.||...|..||:.. ..|:...|
  Rat   405 ---------YQM---HKP-----------FYRSLFALAHTPRCLQHFCRCAIRKLFGKECIHLVP 446

  Fly   542 EVQERYLPTQERSSLGRIVDEFAIPATLKRYL 573
            :     ||               :|.||:.||
  Rat   447 Q-----LP---------------LPETLQNYL 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9121	NP_608901.1	ANK	151..300	CDD:238125	45/164 (27%)
		ANK repeat	151..179	CDD:293786	11/32 (34%)
		Ank_2	153..244	CDD:289560	30/92 (33%)
		ANK repeat	181..210	CDD:293786	12/30 (40%)
		ANK repeat	213..244	CDD:293786	7/30 (23%)
		Ank_2	218..304	CDD:289560	22/94 (23%)
		ANK	241..362	CDD:238125	24/136 (18%)
		ANK repeat	246..277	CDD:293786	10/39 (26%)
		ANK repeat	279..304	CDD:293786	5/24 (21%)
		Ank_4	311..362	CDD:290365	5/57 (9%)
		SOCS_box	518..574	CDD:284857	16/57 (28%)
Asb18	NP_001101701.1	ANK	122..237	CDD:238125	38/142 (27%)
		ANK repeat	122..149	CDD:293786	8/54 (15%)
		Ank_2	124..214	CDD:289560	33/117 (28%)
		ANK repeat	151..182	CDD:293786	10/30 (33%)
		ANK repeat	184..214	CDD:293786	12/29 (41%)
		Ank_5	204..254	CDD:290568	13/49 (27%)
		ANK	218..>358	CDD:238125	35/190 (18%)
		ANK repeat	218..249	CDD:293786	7/30 (23%)
		Ank_5	283..334	CDD:290568	15/79 (19%)
		ANK repeat	293..324	CDD:293786	8/50 (16%)
		ANK repeat	326..357	CDD:293786	6/53 (11%)
		SOCS_ASB4_ASB18	420..467	CDD:239693	16/59 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	77	1.000	Inparanoid score	I5149
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.980