DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9121 and asb3

DIOPT Version :9

Sequence 1:	NP_608901.1	Gene:	CG9121 / 33732	FlyBaseID:	FBgn0031675	Length:	600	Species:	Drosophila melanogaster
Sequence 2:	NP_001191998.1	Gene:	asb3 / 100497433	XenbaseID:	XB-GENE-989169	Length:	522	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	126/557 - (22%)
Similarity:	197/557 - (35%)	Gaps:	162/557 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 TAVGTAAILGDAELLELLLQ---SCEEPELN---VFHQS----NTDSLEIERTPEGMEKLEWVDE 96
            ::||.||.:|||:.|..|::   |.:.|:..   ..|::    :|..|::
Frog    12 SSVGHAARIGDAKSLRKLIKKGSSVDVPDNRGWMPIHEAAFSKSTHCLQL--------------- 61

  Fly    97 FENSAENGAGSGEEDSQLYQYYAKTFETTGEFISSQCCVSCREHDPHLYDADVATPLHYAAYWGH 161
            ..:||.:.:          ...|||||  ||                       |.||.||..|.
Frog    62 LIHSAPSSS----------YIRAKTFE--GE-----------------------TALHLAAKSGS 91

  Fly   162 EECVRILLEHNAPINVLNNDGYAPLHLG--AGFAGVTELLIKHGALVNAKTLSDGKTALHMAIES 224
            ..||::||:..|..|.:.|:...||.|.  .|...|.|||:|:.|.:|......|...||.|...
Frog    92 VRCVQLLLQAGADPNEVTNEETTPLFLAVEGGHKEVVELLLKNKANINGPHSCSGWNPLHQASLM 156

  Fly   225 KCAESARLLLQTNININDTDDDGETPLMAAIACSMLDVAEELVKRGARINIQDKQNHTALQYAVR 289
            ...:...|||:..::....||.|.||...|......:....|:..||..:.|.|...|.|..|.:
Frog   157 GRTDIILLLLENGVDKECEDDFGITPTFIASQYGKYESLNLLLLHGANSDCQAKDKATPLFIAAQ 221

  Fly   290 GRHTQMAKLLLERGARRLASQHL----------LHLAVESNVKELVELLLQYGESLSVWNLKNFT 344
            ..|.:..:|||.:|    |..:|          :|.|.:....:.::|||...:|.........:
Frog   222 EGHDKCVELLLSKG----ADPNLYCNDDNWQLPIHAAAQMGQSKTLDLLLPVTDSAGGVENGKVS 282

  Fly   345 PIMLAIHRGRHEMLEYLLNVAEEQRKLGLYSDVHDEGLVLFAVQQNFWVKEFSRILRVLLAKSPS 409
            |:..|::.|..:.||.||                                        :...||.
Frog   283 PVYSAVYGGHKDCLEKLL----------------------------------------MSGYSPE 307

  Fly   410 ARNDFYDSCAPTIVCGLIYCHTPLSRAINLHRLEVAEFLIHEGCNLA----QICREHVVNE---- 466
            |:.           |.|..|.||:.........|:...|:..|..|:    ..|.|:...:
Frog   308 AQK-----------CPLFGCETPMCMVFQRRHFEMVPVLLKYGFRLSSAHLMCCLENKTFDLFRY 361

  Fly   467 -LRSNC-TPTR---LAFARLLCNAGFQFPHKHRPLPKDWPPARLEFEREMCLLGTQPRSL----- 521
             |...| .|:.   .|.::.:|||..::        ::|.|       ::.|.|..|..|
Frog   362 FLNQRCPLPSGKEVAALSQYVCNAQREW--------EEWLP-------DLLLAGFDPLLLLEATW 411

  Fly   522 QSLARLEIRRSLLRCLQTR--PEVQERYLPTQERSSL 556
            .|.|..:|....|.....:  |...|:||.||.::|:
Frog   412 MSSANDDILNFTLEFSDWKRLPRHVEQYLSTQGKASV 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9121	NP_608901.1	ANK	151..300	CDD:238125	47/150 (31%)
		ANK repeat	151..179	CDD:293786	12/27 (44%)
		Ank_2	153..244	CDD:289560	30/92 (33%)
		ANK repeat	181..210	CDD:293786	11/30 (37%)
		ANK repeat	213..244	CDD:293786	7/30 (23%)
		Ank_2	218..304	CDD:289560	24/85 (28%)
		ANK	241..362	CDD:238125	32/130 (25%)
		ANK repeat	246..277	CDD:293786	7/30 (23%)
		ANK repeat	279..304	CDD:293786	7/24 (29%)
		Ank_4	311..362	CDD:290365	12/60 (20%)
		SOCS_box	518..574	CDD:284857	13/46 (28%)
asb3	NP_001191998.1	PHA02874	17..>267	CDD:165205	76/303 (25%)
		ANK repeat	42..76	CDD:293786	6/58 (10%)
		ANK repeat	78..109	CDD:293786	15/55 (27%)
		Ank_2	83..176	CDD:372319	30/92 (33%)
		ANK repeat	111..142	CDD:293786	11/30 (37%)
		ANK repeat	145..176	CDD:293786	7/30 (23%)
		ANK repeat	178..209	CDD:293786	7/30 (23%)
		ANK repeat	211..240	CDD:293786	9/32 (28%)
		ANK repeat	314..339	CDD:293786	5/24 (21%)
		SOCS_ASB3	456..506	CDD:239692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	73	1.000	Inparanoid score	I5117
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.050