DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Col4a1 and CG42342

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001189234.1	Gene:	CG42342 / 7354466	FlyBaseID:	FBgn0259244	Length:	831	Species:	Drosophila melanogaster

Alignment Length:	813	Identity:	270/813 - (33%)
Similarity:	329/813 - (40%)	Gaps:	273/813 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   532 RPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGAR 596
            |.....||.|...:|.:|                 ||:| .|:.||.
  Fly   217 RQAAEAAAAAASGEGGSG-----------------GGQC-QCQPGPP------------------ 245

  Fly   597 GPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGA 661
            |||                  ||||::|:.|:                        |||.|..|.
  Fly   246 GPP------------------GPPGKRGKRGK------------------------KGDSGEKGD 268

  Fly   662 PGAKGVQGFKGAEGLPGIPGPKGEFG------FKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSI 720
            ||..|:.|.|||.|.||..|.||:.|      |:..|||.    ...|....|..||..|.....
  Fly   269 PGLNGISGEKGAAGKPGDKGQKGDVGHPGMDVFQTVKGLK----RSVTTLHGGTLGYAEIVAVKD 329

  Fly   721 KGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGER 785
            ..|.|.:                      ..|...||:     |||||:.|.||||||.|.|
  Fly   330 LQEAGVN----------------------VSASTVIKL-----KGEPGEPGPPGPPGEAGQP--- 364

  Fly   786 GYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGI 850
                        |.||..||                              ||..|..||:||.|
  Fly   365 ------------GAPGERGP------------------------------PGEIGAQGPQGEAG- 386

  Fly   851 SRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGP 915
             :||..||||:.|..|.|||:                  |||||.||...     |.|::...|.
  Fly   387 -QPGVAGPPGVAGAPGTKGDK------------------GDRGDRGLTTT-----IKGDEFPTGI 427

  Fly   916 I-GPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGND--GPKGF-------- 969
            | ||.|.|||||.|      |..||:||||..|..|.||.||.||..|..  ||.|.
  Fly   428 IEGPPGPAGPPGPP------GEPGARGEPGPIGPAGPPGEKGPRGKRGKRIFGPGGTKIDEDYDD 486

  Fly   970 AGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQG 1034
            ..||..   |||.|.||::|.         .|.||..|.:|.||.||..|..|.:||.|.||:.|
  Fly   487 PPVTLL---RGPPGPPGIAGK---------DGRDGRDGSKGEPGEPGEPGSLGPRGLDGLPGEPG 539

  Fly  1035 LDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHG 1099
            ::|.|      |.||..||||      |||.:|:.||.||.|..|..|.||:||.|
  Fly   540 IEGPP------GLPGYQGPPG------EKGDRGDIGPPGLMGPPGLPGPPGYPGVK--------- 583

  Fly  1100 RAGPPGEKGDQGRSGIDGR----DGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGA 1160
                 |:|||:|.|....|    ||::.......::.::|.||..|.:|.||..|:.|..||.|.
  Fly   584 -----GDKGDRGDSYRKMRRRQDDGMSDAPHMPTIEYLYGPPGPPGPMGPPGHTGSQGERGLDGR 643

  Fly  1161 AGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIR 1225
            .|.||..|:.||:|..|.|            ||:|::|.:|..||.|:.||.|.|||.
  Fly   644 KGDPGEKGHKGDQGPMGLP------------GPMGMRGESGPSGPSGKAGIPGPPGLD------- 689

  Fly  1226 GDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGY 1290
            |.||:|||   ||.|||:|:.||.|..|:.|.:|.||.||..|.:|..|..|.|||.|.:||.|.
  Fly   690 GMKGAQGE---TGHKGERGDPGLPGTDGIPGQEGPRGEQGSRGDAGPPGKRGRKGDRGDKGEQGV 751

  Fly  1291 PGVTIK---GEKGLPGRPG---RNGRQGLIGAP 1317
            ||:...   |..||| .||   |..::.:|..|
  Fly   752 PGLDAPCPLGADGLP-LPGCGWRPPKEPIISTP 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968
		Collagen	322..380	CDD:189968
		Collagen	413..465	CDD:189968
		Collagen	499..561	CDD:189968	6/28 (21%)
		Collagen	574..632	CDD:189968	11/57 (19%)
		Collagen	657..714	CDD:189968	24/62 (39%)
		Collagen	765..824	CDD:189968	18/58 (31%)
		Collagen	854..911	CDD:189968	19/56 (34%)
		Collagen	884..943	CDD:189968	24/59 (41%)
		Collagen	923..982	CDD:189968	28/68 (41%)
		Collagen	1028..1085	CDD:189968	24/56 (43%)
		Collagen	1229..1287	CDD:189968	28/57 (49%)
		Collagen	1318..1376	CDD:189968	270/813 (33%)
		Collagen	1399..1458	CDD:189968
		Collagen	1477..1534	CDD:189968
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
CG42342	NP_001189234.1	DUF4763	130..>210	CDD:292582
		Collagen	366..413	CDD:189968	28/96 (29%)
		Collagen	660..718	CDD:189968	32/79 (41%)
		Collagen	690..748	CDD:189968	30/60 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24023
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010