DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col24a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_082046.2	Gene:	Col24a1 / 71355	MGIID:	1918605	Length:	1733	Species:	Mus musculus

Alignment Length:	1680	Identity:	560/1680 - (33%)
Similarity:	675/1680 - (40%)	Gaps:	580/1680 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 MEGPSGDKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIP 175
            :.||.||.|..|.|||         .|.||..|:.|..|:.||.||||.|
Mouse   506 LRGPKGDPGPPGPPGP---------MGIPGPSGKRGPRGIPGPHGNPGLP--------------- 546

  Fly   176 GLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGD 240
                  |:|||         ||.||:|....|..|.||||:|   |..||.||.|..|.|
Mouse   547 ------GLPGP---------KGPKGDPGLSPGQAASGEKGDP---GLLGLVGPPGLQGAK----- 588

  Fly   241 SGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGE 305
                         ||||.          ||.||::||.|.|                |..|..|.
Mouse   589 -------------GLKGH----------PGLPGLRGEHGLP----------------GLAGNIGS 614

  Fly   306 PGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPG 370
            ||..||:|..||||:.|..|.:|..|.||..|..|.:|..|.||..|:||.:|..|.      ||
Mouse   615 PGYPGRQGLAGPEGNPGSKGVRGFIGSPGEVGQLGPEGERGTPGVRGKKGPKGRQGF------PG 673

  Fly   371 QKGEPGRAGATGKPGLLGPPGPPG--GGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYN 433
            ..|:.|.||..|.|||:|..||||  |..|:.||.||.||   .|||||.||:|..|..|.:|..
Mouse   674 DFGDRGPAGLDGSPGLVGGTGPPGFPGVTGSVGPAGPTGP---PGAPGPMGLSGSRGPSGIKGDK 735

  Fly   434 GQKGGAGLPGRP------GNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGY 492
            |::|.||.||.|      ||.|.||..|.:|.:|.:|..|..||.|..|||||||..||.|:||.
Mouse   736 GEQGVAGEPGEPGYPGDKGNIGSPGPPGIRGKSGPSGQPGDPGPQGPSGPPGPEGFPGDIGIPGQ 800

  Fly   493 ----GIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGT 553
                |.:|..|:.|.||.|||||::||.|           .:|..|..|:.|.||:||..|.||.
Mouse   801 NGPEGPKGHLGNRGPPGPPGLKGTQGEEG-----------PIGPFGELGSRGKPGRKGYMGEPGP 854

  Fly   554 PGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTG 618
            .|.||::|.:||:         |..|:.|..||||..|..|:.|..||||.|         |..|
Mouse   855 EGLKGEVGDQGDI---------GKTGETGPVGLPGEVGITGSIGEKGERGSP---------GPLG 901

  Fly   619 PPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPK 683
            |.||||.                              .||||.|||               |||.
Mouse   902 PQGEKGV------------------------------MGYPGPPGA---------------PGPM 921

  Fly   684 GEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEP 748
            |..|..|..|..||||:.|.                 ||:.|..|.||..||:|..|
Mouse   922 GPLGLPGLVGARGAPGSPGP-----------------KGQRGPRGPDGLAGDQGGHG-------- 961

  Fly   749 GSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRG 813
                       |||.||..|:.|:||.||:.|||||||.
Mouse   962 -----------AKGEKGNQGKRGLPGLPGKAGSPGERGV-------------------------- 989

  Fly   814 EKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIG 878
                         .||.|.:|:||.:|..||.||     |||.|.||:.||.||.|..||.|..|
Mouse   990 -------------QGKPGFQGLPGSSGDVGPAGE-----PGPRGLPGIAGLPGEMGVEGPPGTEG 1036

  Fly   879 FPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEP 943
            ..|..|..|..||.|.||..|.:|.||..||               ||.||.:|::|:||.||.|
Mouse  1037 DSGLQGEPGAKGDGGPAGSAGATGEPGPRGE---------------PGAPGEEGLQGKDGLKGAP 1086

  Fly   944 GSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGG 1008
            |..||.|..|:||:.|.||..||.|..|..|.||..|..|.||..|..|.||..|..|..|..|.
Mouse  1087 GGSGLPGEDGDKGEMGLPGTAGPVGRPGQMGLPGPEGIVGTPGQRGRLGKKGDKGQVGPTGEAGS 1151

  Fly  1009 RGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSG 1073
            |||||:.|..|.||.:|..||.|..||.|..||            ||:||   .:|.:|:|||||
Mouse  1152 RGPPGSVGENGPKGARGTRGAVGPLGLMGPEGE------------PGIPG---YRGHQGQPGPSG 1201

  Fly  1074 LRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPG 1138
            |   .||.|..|:|||..    .|.|..|||||.|..               ||||..|..|:.|
Mouse  1202 L---PGPKGEKGYPGEDS----TVLGPPGPPGEPGPM---------------GEQGETGEHGEEG 1244

  Fly  1139 EKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAP 1203
            .||.:|.||:.||.|..|.||.         |||:|.:|.         |||.|..|.||..|.|
Mouse  1245 YKGHMGVPGLRGATGQQGPPGE---------PGDQGGQGP---------KGERGSEGPQGKRGVP 1291

  Fly  1204 GPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPG 1268
            ||.|:.||.|.||.|                                        |.:||||.||
Mouse  1292 GPSGKPGIPGVPGFP----------------------------------------GPKGLQGYPG 1316

  Fly  1269 ASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPG 1333
            ..|::|.||..|              :.|::||.|.||..||.|:.|:|   |.:|..|.:|.||
Mouse  1317 VDGMSGYPGKPG--------------LPGKQGLLGVPGSPGRTGVAGSP---GPQGGKGASGPPG 1364

  Fly  1334 LVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDR 1398
            ..|.|||      |||:||.|.||.|||.|..|.|      |.||.:|..||   :||.|:.||:
Mouse  1365 SPGAPGP------KGEQGLPGQPGVPGQRGHRGTP------GDQGLRGAPGL---KGQPGEHGDQ 1414

  Fly  1399 GLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPP 1463
            ||.|..|.||..|.:||.|..|:.|..||:   |:||.|||.||:
Mouse  1415 GLAGFQGFPGPRGPEGDAGIVGIVGPKGPI---GQRGNTGPLGRE-------------------- 1456

  Fly  1464 PGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERG 1528
                                     |:||..|..|.:||:|..|||      ||:|.||:|
Mouse  1457 -------------------------GIIGPTGGTGPRGEKGFRGET------GPQGPRGQP---- 1486

  Fly  1529 YEGAIGLIGQKGEPGAPAP-------AALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYV 1586
                    |..|.||||.|       ||:..|             :.:.||...|     |....
Mouse  1487 --------GPPGPPGAPGPRRQMDINAAIRAL-------------IESNSAQQME-----SYQNT 1525

  Fly  1587 DGNDYAHNQDLGSPGSCVPRFSTLPVLS-------------------CGQNNVCNYASRNDKTFW 1632
            :|...:|:.|:         |.||..||                   |.....|.| ..:|..:|
Mouse  1526 EGTLISHSSDI---------FKTLTYLSSLLSSIKNPLGTRENPARICKDLLSCQY-KVSDGKYW 1580

  Fly  1633 LTTNAAIP-----------------MMPVENIEIRQYISRC------VVCEAPANVIAVH----- 1669
            :..|....                 :.||...::...:|:.      ::.....:.|.:|
Mouse  1581 IDPNLGCSSDAFEVFCNFSAGGQTCLSPVSVTKLEFGVSKVQMNFLHLLSSEATHTITIHCLNTP 1645

  Fly  1670 ---SQTIEVPDCP---NGW-----------------------EGLWIGYSFLMHT 1695
               |...:.|:.|   .||                       :|.|....||.||
Mouse  1646 RWSSTWADGPELPISFKGWNGQIFEENTLLEPQVLSDDCKIQDGSWHKAKFLFHT 1700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	21/49 (43%)
		Collagen	322..380	CDD:189968	22/57 (39%)
		Collagen	413..465	CDD:189968	26/57 (46%)
		Collagen	499..561	CDD:189968	26/61 (43%)
		Collagen	574..632	CDD:189968	22/57 (39%)
		Collagen	657..714	CDD:189968	19/56 (34%)
		Collagen	765..824	CDD:189968	14/58 (24%)
		Collagen	854..911	CDD:189968	28/56 (50%)
		Collagen	884..943	CDD:189968	23/58 (40%)
		Collagen	923..982	CDD:189968	29/58 (50%)
		Collagen	1028..1085	CDD:189968	23/56 (41%)
		Collagen	1229..1287	CDD:189968	12/57 (21%)
		Collagen	1318..1376	CDD:189968	24/57 (42%)
		Collagen	1399..1458	CDD:189968	22/58 (38%)
		Collagen	1477..1534	CDD:189968	17/56 (30%)
		C4	1555..1662	CDD:128421	21/148 (14%)
		C4	1663..1777	CDD:128421	13/67 (19%)
Col24a1	NP_082046.2	LamG	41..230	CDD:389952
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..335
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..1499		523/1449 (36%)
		Collagen	531..594	CDD:189968	37/123 (30%)
		Collagen	577..634	CDD:189968	32/100 (32%)
		Collagen	613..670	CDD:189968	26/56 (46%)
		Collagen	722..771	CDD:189968	20/48 (42%)
		Glutenin_hmw	<931..1424	CDD:367362	262/714 (37%)
		Collagen	1397..1454	CDD:189968	29/62 (47%)
		COLFI	1550..1732	CDD:382971	22/152 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910