DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and col17a1b

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_697241.4	Gene:	col17a1b / 568794	ZFINID:	ZDB-GENE-030131-7145	Length:	1542	Species:	Danio rerio

Alignment Length:	1329	Identity:	414/1329 - (31%)
Similarity:	522/1329 - (39%)	Gaps:	439/1329 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FWK----RLLYAAVIAGALVGADA---QFWKTAGTAGSIQDSVKHYNRNEPKF--PIDDSYDIVD 59
            :||    .||...::.|.|.|..|   :..|......:::......|.:..:.  |||.    :|
Zfish   523 WWKWLLGFLLGLLLLLGLLFGLIALSEEVKKLKSRVSTLEAMSSSMNAHTSRLSAPIDG----ID 583

  Fly    60 SAGVARGDLPPKNCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEG--PSGDKGQKG 122
            ..|          ..|.|...:...: ...|.||...:... ::.||....|..  .|..|.::|
Zfish   584 EVG----------SKAAYVNSLDSAV-NSDNIGLQRNVQQI-VRAEMQSEQMRAYLASSVKAERG 636

  Fly   123 DPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPR 187
            .|||      ||:.||||..|..|.||:.||   ||.||.:|:||..|:.|..|..|..|.   |
Zfish   637 LPGP------KGDSGSPGTRGDNGFPGIPGP---PGMPGHSGRDGQKGEKGSAGEHGAEGF---R 689

  Fly   188 GYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGE 252
            |..||.|.:||.|.|       ..|||||.|..|..||.||.|..|..|..|:.||.|.:|..|.
Zfish   690 GRDGQPGPRGEPGPP-------GAGEKGERGSPGLPGLIGPPGAKGSSGLHGEQGPQGFRGEPGP 747

  Fly   253 HGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGP 317
            .|.||::|.       ||.|||||:.|:                ||:.|..|.||:|||:|..|.
Zfish   748 AGPKGDRGL-------PGLPGIKGDHGD----------------RGENGLPGIPGVVGRQGPAGE 789

  Fly   318 EGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLP---GNPGQKGEPGRAG 379
            :||                     :|:.||.|:.|:||.|||||..|||   |.||..|:||::|
Zfish   790 KGD---------------------KGSAGPQGADGEKGQRGEPGSIGLPGIRGPPGPHGDPGQSG 833

  Fly   380 ATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGR 444
            |   ||:.||||.|    |.||.|||||..|..|    :.:|.....           ...:||.
Zfish   834 A---PGIQGPPGLP----GNPGQPGPKGETGEAG----RVINAAGST-----------SVAIPGP 876

  Fly   445 PGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGL 509
            ||:.|||   |..|:.||:||   :||.|.|||||.:|.|||.|.||.|:  :.|:.       |
Zfish   877 PGSAGPP---GPPGSPGLSGP---VGPAGLPGPPGVKGDKGDQGEPGIGV--NTGET-------L 926

  Fly   510 KGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCR 574
            ..::.||.:    ||......|.||.||..|.||:.||: |||.|
Zfish   927 VSTRAERQY----GAVNVGGTGLPGPPGPPGPPGRPGDS-RPGPP-------------------- 966

  Fly   575 AGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGA----T 635
                                  |||||.||          |:.||.|||||.|.. :|.:    .
Zfish   967 ----------------------GPPGEPGY----------GRPGPKGEKGEPGNF-VPNSGTFFA 998

  Fly   636 GEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKG----EFGFKGEKGLSG 696
            |.||.|            |..|..|..|.:|.:|:.|..|.||:||..|    |:|.  .:|..|
Zfish   999 GPPGPP------------GPTGPKGPTGPQGPRGYTGEPGQPGLPGSSGRVISEYGV--AQGPPG 1049

  Fly   697 APGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAK 761
            .||..|.|||.||.|.||:||.|.     |.|....                           |.
Zfish  1050 PPGPPGPPGREGRKGDPGVPGTST-----FQGESRV---------------------------AA 1082

  Fly   762 GNKGEPGQTGMPGPPGEDGSPGE--------RGY------TG-----LKGNTGPQGPPG----VE 803
            .::|.||.   |||||..|:||:        |.|      :|     |.|..||.||||    ||
Zfish  1083 THQGRPGP---PGPPGPPGAPGQSSGSAADYRRYIMEYMQSGSMRQHLSGIQGPPGPPGASVSVE 1144

  Fly   804 GPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPG-------L 861
                          ..|..|.....:.|:.|........||:|.     |||.||||       :
Zfish  1145 --------------DVASRVIAYIQRSGISGGSISQSAQGPQGP-----PGPPGPPGSITADYII 1190

  Fly   862 NGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRP-----------GIVGEKGDVGP 915
            :.||.:...|...||.|.||:               ||:||..           .::.|:|.:|.
Zfish  1191 SLLQRDDVRRYVAGPPGPPGS---------------PGISGSSFNTQEVANYVMRMMNEQGMIGR 1240

  Fly   916 IGPAGVAGPPGVPG-----IDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTG- 974
            .||.|..||||.||     |..:..|.|..|..|.|   |.||..|..|.||..|....| |:|
Zfish  1241 AGPPGPPGPPGQPGATYSDITALIQRSGIGGSIGRP---GPPGPMGPPGPPGASGGSSSA-VSGY 1301

  Fly   975 ----------APGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGA 1029
                      ..|.|||.|:|                  ||.|.:||||        ..:.|...
Zfish  1302 SLEDIQRYLQKSGFRGPPGLP------------------GPAGPQGPPG--------DTRSLVSY 1340

  Fly  1030 PGQQGLDGMPGEKGNQGFPGLD-------GPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWP 1087
            .|....:.:..|.  |.:...|       |||||||...:||.:||||.|...|..
Zfish  1341 TGSSAREQIRTEL--QDYLNSDTMRRYVQGPPGLPGPPGQKGDRGEPGYSYQNGRN--------- 1394

  Fly  1088 GEKGLPGLAVHGRAGPP-GEKGDQGRSGIDGRDGINGEKGEQGL-----QGVW-GQPGE-KGSVG 1144
                      ..|.|.. .|..|.....:...|.|.    :|||     :|.| .|.|. :|..|
Zfish  1395 ----------QYRYGTEISEPVDYSNVALKVTDYIK----DQGLLQDLTEGYWRSQAGSIQGPAG 1445

  Fly  1145 APGIPGAPG---------------MD---------GLPGAAGAPGAVGYPGDRGDKGEPGLSGLP 1185
            .||.||.||               ||         |.||.:|..|..||||.:|:||:.|.||:|
Zfish  1446 PPGPPGPPGYSRVIGAYGNVTADLMDFFRTYGTIPGPPGRSGPKGERGYPGPKGNKGDTGSSGIP 1510

  Fly  1186 GLKGETGPVGLQGFTGAPGPKGERGIRGQ 1214
            ||.|:.||         .||:||:|.:|:
Zfish  1511 GLPGQRGP---------EGPRGEKGEKGE 1530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	23/58 (40%)
		Collagen	322..380	CDD:189968	21/60 (35%)
		Collagen	413..465	CDD:189968	13/51 (25%)
		Collagen	499..561	CDD:189968	20/61 (33%)
		Collagen	574..632	CDD:189968	16/57 (28%)
		Collagen	657..714	CDD:189968	25/60 (42%)
		Collagen	765..824	CDD:189968	25/81 (31%)
		Collagen	854..911	CDD:189968	19/74 (26%)
		Collagen	884..943	CDD:189968	20/74 (27%)
		Collagen	923..982	CDD:189968	26/74 (35%)
		Collagen	1028..1085	CDD:189968	19/63 (30%)
		Collagen	1229..1287	CDD:189968
		Collagen	1318..1376	CDD:189968
		Collagen	1399..1458	CDD:189968
		Collagen	1477..1534	CDD:189968
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
col17a1b	XP_697241.4	Collagen	708..764	CDD:189968	28/62 (45%)
		Collagen	737..796	CDD:189968	31/102 (30%)
		Collagen	776..840	CDD:189968	35/87 (40%)
		Collagen	1480..1527	CDD:189968	25/55 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910