DRSC/TRiP Functional Genomics Resources

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Protein Alignment Col4a1 and col11a1a

DIOPT Version :9

Sequence 1:NP_723044.1 Gene:Col4a1 / 33727 FlyBaseID:FBgn0000299 Length:1779 Species:Drosophila melanogaster
Sequence 2:XP_005162870.1 Gene:col11a1a / 565402 ZFINID:ZDB-GENE-070209-167 Length:1814 Species:Danio rerio


Alignment Length:1705 Identity:618/1705 - (36%)
Similarity:755/1705 - (44%) Gaps:428/1705 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 AGTAGSIQDSVKHYNRNEPKFPIDDSYDI--VDSAGVAR-----------GDLPPKNCTAGYAGC 80
            :|||..|  .|..|:..|        ||:  .|..|:.:           |::.| |.|:.|...
Zfish   356 SGTADPI--GVDSYDFKE--------YDLKEYDVTGLDKNQYEYGPYDEFGNVAP-NPTSNYEDT 409

  Fly    81 V-PKCIAE----KGNRGLPGPLGPTGLKGEMGF--PGM--EGPSGDKGQKGDPGPYGQRGDKGER 136
            . |...||    :.:.|....||..|.|||...  |||  |||||..|..|.|||          
Zfish   410 FGPGVAAETDIAETDLGGGAALGQKGEKGEPAVIEPGMLIEGPSGPPGPAGLPGP---------- 464

  Fly   137 GSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQL----GSKG 197
                       ||:|||.|..|.||..|.   .|:.|:||.:||   |||.|....|    |..|
Zfish   465 -----------PGLQGPPGLAGDPGDRGP---PGRAGLPGADGL---PGPPGTMLMLPFRFGGDG 512

  Fly   198 EKGEPAKENGDYAK--------GEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHG 254
            |||.........|:        ..:|.||..|..|.:||.|.||..|.:|:||.:|.:||||   
Zfish   513 EKGPVVSAQEAQAQAILSQARLAMRGPPGPMGLTGRSGPVGLPGPPGLKGESGDHGPQGPRG--- 574

  Fly   255 LKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEG 319
                                                  :.||.|.:|:.|:.|..|..|..|..|
Zfish   575 --------------------------------------IQGPPGQIGKPGKRGRAGADGARGMPG 601

  Fly   320 DTGLDGQKGEKGLPGGPGDRGRQGN---FGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGAT 381
            ::|..|.:|..||||.||::|.:|.   .||||.||:.|.|||         .|:.|..|.||.:
Zfish   602 ESGSKGDRGFDGLPGLPGEKGHRGETGPAGPPGPTGEDGPRGE---------DGEIGPRGLAGES 657

  Fly   382 GKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPG 446
            |..|||||.||       |||||..|..|..|..||:|..|..|.|||.|..|..||.||||..|
Zfish   658 GPRGLLGPRGP-------PGPPGQPGIAGVDGPQGPKGNMGPQGEPGPPGQQGIPGGQGLPGPQG 715

  Fly   447 NEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKG 511
            ..||||:||.:|.:||.|..|:.||.||||..||.|:||..|.|     |.:|..|.||..|:||
Zfish   716 PIGPPGEKGPQGRSGLPGLPGADGPPGHPGKEGPPGEKGALGQP-----GPQGPIGYPGPRGVKG 775

  Fly   512 SKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAG 576
            :.|.||.||.                       ||:.|..|.||.|||||:              
Zfish   776 ADGVRGLKGG-----------------------KGEKGEDGFPGFKGDMGL-------------- 803

  Fly   577 PKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKP 641
             |||:|..||.|..|:||..||         :|..|.||::||.|..||.|:.|:||..|.||: 
Zfish   804 -KGDRGELGLAGPRGEDGPEGP---------KGRAGPNGESGPQGSAGEKGKLGVPGLPGYPGR- 857

  Fly   642 ALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGR 706
                    :..||..|:||.|||.|.:|.:|..|..|..|.:|..|.:|.:|..|..|..|..|.
Zfish   858 --------QGPKGSTGFPGFPGANGEKGGRGVAGKAGPRGQRGPTGPRGARGARGPTGKPGPKGT 914

  Fly   707 AGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTG 771
            ||.||.||.||:.           |.:|.:|..|..|.||.|                |.||:.|
Zfish   915 AGNDGPPGPPGER-----------GPQGPQGPVGFPGPKGPP----------------GPPGKDG 952

  Fly   772 MPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIP 836
            :|      |.||:||.||.:|.|||.||.||.||:   ||.||.|..|..|.||.||..|.:|:|
Zfish   953 LP------GHPGQRGETGFQGKTGPPGPGGVVGPQ---GPTGETGPIGERGHPGPPGPPGEQGLP 1008

  Fly   837 GRNGQPGPRGEPG-ISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGAD------GSVGYPGDRGD 894
            |..|:.|.:|:|| ...||..|||||.|..||:|..|.|||.|..||:      |.||.||:||.
Zfish  1009 GAGGKEGAKGDPGPQGSPGKDGPPGLRGFPGERGLPGVTGPPGLKGAEGPQGPPGPVGSPGERGA 1073

  Fly   895 AGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRG 959
            ||..|..|.||..|.:   ||.||||..|.||..|..|..||||.:|.      ||:||..|.:|
Zfish  1074 AGSAGPIGLPGRTGPQ---GPPGPAGEKGAPGERGPLGPAGRDGVQGP------VGLPGPAGPQG 1129

  Fly   960 APGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQ 1024
            .||.||.|            |..|.||..|:|.|||.   .|..||.|.:||.||||..|..|: 
Zfish  1130 PPGEDGDK------------GEVGEPGQKGSKADKGE---QGPPGPPGLQGPIGAPGPAGADGE- 1178

  Fly  1025 GLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGE 1089
              .|..||||:.|..|::|::||||..||.||      :|..|.||..|..||.||.|.||.||.
Zfish  1179 --PGPRGQQGMFGQKGDEGSRGFPGPPGPIGL------QGLPGPPGEKGENGDVGPMGPPGPPGP 1235

  Fly  1090 KGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGM 1154
            :        |..||||..|.||..|..|..|..|||||||..|..|.|||.|..|..|..|..|.
Zfish  1236 R--------GPQGPPGADGPQGPPGGIGGMGAVGEKGEQGEAGNPGPPGEPGPGGPKGERGEKGE 1292

  Fly  1155 DGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPA 1219
            .|.|||||..|..|.|||.|.||.||..|.||..|..|..|:.|..|.||.|||.|..||||.| 
Zfish  1293 AGPPGAAGPAGPKGPPGDDGPKGNPGPVGFPGDPGPPGEPGVAGIDGGPGEKGEDGESGQPGPP- 1356

  Fly  1220 TVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGP 1284
                           |.:||.|..|..|..||.|..||:|.:|.:|..|.:||.|.||..|.:||
Zfish  1357 ---------------GPSGEAGPPGPPGKRGPPGAHGAEGRQGEKGAKGEAGLEGPPGKTGPVGP 1406

  Fly  1285 RGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGE 1349
            :|..|.|                 |.:||.|.||.:||:|||   |.||..|.|||:||      
Zfish  1407 QGPSGKP-----------------GPEGLRGIPGPVGEQGLP---GAPGQDGPPGPMGP------ 1445

  Fly  1350 RGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGF---EGQKGDKGDRGLQGPSGLPGLVG 1411
                           ||.||||||.|.:|.||..||.|.   .|::|:||||||.||.   |..|
Zfish  1446 ---------------PGLPGLKGDPGSKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQ---GAAG 1492

  Fly  1412 QKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRN 1476
            .|||.   |::|..||:|.||..|..||:|..|..|:.|..||||:.|.:.||||.|.||:..:.
Zfish  1493 SKGDN---GISGASGPIGPPGPPGLPGPQGPKGSKGSTGPAGQKGDTGTVGPPGPPGPPGEVIQP 1554

  Fly  1477 GPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGE 1541
            .|...|.:  .|..|.:|.:..                 |...|.|| |......::..:.|..|
Zfish  1555 LPIHSPKK--SRRSIDMQADEA-----------------GTMLDYGE-GMEDIFSSLNNLKQDIE 1599

  Fly  1542 PGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYVDGNDYAHNQDLGSPGSCVPR 1606
                   .:.|..|   |:::.:.:.......|.|...|.  .|:|.|.       |..|.....
Zfish  1600 -------RMKYPMG---TQNNPARSCKDLQLAHPEFPDGE--YYIDPNQ-------GCSGDSFKV 1645

  Fly  1607 FSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIPMMPVENIEIRQYISRCVVCEAPANVIAVHSQ 1671
            :             ||:.:..:                          .|:..:..:|.:.:.|.
Zfish  1646 Y-------------CNFTAGGE--------------------------TCIFPDKKSNGVRISSW 1671

  Fly  1672 TIEVPDCPNGWEGLW 1686
            ..|||       |.|
Zfish  1672 PKEVP-------GSW 1679

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Col4a1NP_723044.1 Collagen 104..161 CDD:189968 22/60 (37%)
Collagen 322..380 CDD:189968 25/60 (42%)
Collagen 413..465 CDD:189968 27/51 (53%)
Collagen 499..561 CDD:189968 21/61 (34%)
Collagen 574..632 CDD:189968 23/57 (40%)
Collagen 657..714 CDD:189968 24/56 (43%)
Collagen 765..824 CDD:189968 29/58 (50%)
Collagen 854..911 CDD:189968 31/62 (50%)
Collagen 884..943 CDD:189968 30/58 (52%)
Collagen 923..982 CDD:189968 22/58 (38%)
Collagen 1028..1085 CDD:189968 26/56 (46%)
Collagen 1229..1287 CDD:189968 23/57 (40%)
Collagen 1318..1376 CDD:189968 23/57 (40%)
Collagen 1399..1458 CDD:189968 27/58 (47%)
Collagen 1477..1534 CDD:189968 10/56 (18%)
C4 1555..1662 CDD:128421 13/106 (12%)
C4 1663..1777 CDD:128421 7/24 (29%)
col11a1aXP_005162870.1 TSPN 43..233 CDD:214560
Collagen 571..630 CDD:189968 25/99 (25%)
Collagen 722..778 CDD:189968 28/60 (47%)
Collagen 814..873 CDD:189968 29/76 (38%)
Collagen 862..915 CDD:189968 21/52 (40%)
Collagen <1383..1425 CDD:189968 20/58 (34%)
COLFI 1586..1812 CDD:279718 23/159 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BAFZ
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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