DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and col2a1a

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_571367.1	Gene:	col2a1a / 562496	ZFINID:	ZDB-GENE-980526-192	Length:	1491	Species:	Danio rerio

Alignment Length:	1716	Identity:	615/1716 - (35%)
Similarity:	746/1716 - (43%)	Gaps:	439/1716 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GSIQDSVKHYNR----NEP-KFPIDDS----------YDIVDSAG--VARGDLPPKNCTAGYAGC 80
            |.:||..::.:|    .|| :..:.||          .|:.|.|.  ::.|:            |
Zfish    37 GCVQDGQQYADRAVWKPEPCRVCVCDSGTVLCDEVICEDLNDCANPIISPGE------------C 89

  Fly    81 VPKCIAEKGNRGLPGPLGPTGLKGEMGFP-------GMEGPSGDKGQKGDPGPYGQRGDKGERGS 138
            .|.|.|:..:     |:|..|.||:.|.|       |..||:|..|..|:.|..|:||.|||:||
Zfish    90 CPICPADTDD-----PIGSLGAKGQKGEPGDITDVVGPRGPAGPMGPPGEQGTRGERGAKGEKGS 149

  Fly   139 PGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQ---------DGIPGLEGLSGMPGPRGYAGQLG 194
            ||..|:.|.||..|..|.||.||.||..|..|.         |...|...:..|.||      :|
Zfish   150 PGPRGRDGEPGTPGNPGPPGPPGPNGPPGLGGNFAAQMAGGFDEKAGGAQMGVMQGP------MG 208

  Fly   195 SKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEK 259
            ..|.:|.|                  |.:|..|||||.|..||.|:.||.||.||||
Zfish   209 PMGPRGPP------------------GPSGAPGPQGFQGNPGETGEPGPAGALGPRG-------- 247

  Fly   260 GASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLD 324
                    .||.||              ||        |..|:.|:||..|.:|.|||:
Zfish   248 --------PPGPPG--------------KP--------GSDGEAGKPGKAGERGPPGPQ------ 276

  Fly   325 GQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGP 389
               |.:|.|            |.||..|.||.||.|||:|..|..|..|..|.||:.|:.|..||
Zfish   277 ---GARGFP------------GTPGLPGIKGHRGHPGLDGAKGEAGAAGAKGEAGSNGESGAPGP 326

  Fly   390 PGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKK 454
            .||    ||.|      |.||..||.|..|..|.||||||.|..|..|.||.||.||:   ||.|
Zfish   327 MGP----RGLP------GERGRPGATGAAGARGNDGLPGPAGPPGPVGPAGAPGFPGS---PGSK 378

  Fly   455 GEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFK 519
            ||.|..|..||:|:.||.|..|.||..|..|.:|.|           |..|.||.|||.|..|..
Zfish   379 GEAGPTGARGPEGAQGPRGEAGTPGSPGPAGASGNP-----------GTDGIPGAKGSAGASGIA 432

  Fly   520 GNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTS 584
            |..|.||..  |.||..||.|..|.||.:|.||.||.||:.|.||:.|........||.|::|..
Zfish   433 GAPGFPGPR--GPPGPQGATGPLGPKGQSGDPGIPGFKGEAGPKGERGVLGPQGPPGPSGEEGKR 495

  Fly   585 GLPGIPGKDGARGPPGERGYPGER---GHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDL 646
            |..|.||..|..|||||||.||.|   |.||:.|..|.||::|..|.:|..|.||:||:|
Zfish   496 GPRGEPGSAGPLGPPGERGAPGNRGFPGQDGLAGAKGAPGDRGVPGLSGPKGGTGDPGRP----- 555

  Fly   647 SLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDG 711
                      |.||.|||:            |:.|..|:.|.:|:.|.:||||.||.||..|..|
Zfish   556 ----------GEPGLPGAR------------GLTGRPGDAGAQGKVGATGAPGEDGRPGPPGPLG 598

  Fly   712 YPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPP 776
                    .:|:||..|..|.|      |.:||.|:|             |.||..|:||:.|.|
Zfish   599 --------ARGQPGVMGFPGPK------GANGEPGKP-------------GEKGLVGRTGLRGLP 636

  Fly   777 GEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQ 841
            |:|            |.|||.|||   ||.|..|.|||:         |.||..|.:|:||..|.
Zfish   637 GKD------------GETGPSGPP---GPVGAVGERGEQ---------GQPGPSGFQGLPGPTGA 677

  Fly   842 PGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGP---IGFPGADGSVGYPGDRGDAGLPGVSGR 903
            |   ||||  :||..|.|      ||.|..|||||   .||||..|..|..|.:|..||||.
Zfish   678 P---GEPG--KPGDQGVP------GEGGAAGPTGPRGERGFPGERGGAGPQGLQGPRGLPGT--- 728

  Fly   904 PGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKG 968
            ||..|.||.:||.|.||..||||:.|:            ||..|.||:.|.|||||..|..||:|
Zfish   729 PGTDGPKGAIGPAGAAGAQGPPGLQGM------------PGERGAVGISGAKGDRGDSGEKGPEG 781

  Fly   969 FAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQ 1033
            ..|..|:.|..||.|.||.||..|.||.||..|:.|..|.||.||..|.:|..|..|.||.|
Zfish   782 APGKDGSRGLTGPIGPPGPSGPNGAKGETGPIGSIGAPGARGAPGDRGEIGAPGPAGFAGPP--- 843

  Fly  1034 GLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVH 1098
            |.||.||.||.||..|..|..|.||.....|..|..||:|:.|..|..|..|.||..|.||.|
Zfish   844 GADGQPGNKGEQGESGQKGDSGAPGPQGPSGAPGPVGPTGVTGPKGARGAQGAPGATGFPGAA-- 906

  Fly  1099 GRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGA 1163
            ||.||||..|:.|.:|..|..|.:|.|   |::|..|.||..|..|..|.|||||..|..|..|.
Zfish   907 GRVGPPGPNGNPGAAGPAGPSGKDGPK---GVRGDAGPPGRAGDAGLRGPPGAPGEKGEAGEDGP 968

  Fly  1164 PGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDK 1228
            ||..|..|..|..|:.|:.||||.:||      :||.|.|||.||.|.:|.||
Zfish   969 PGPDGPSGPAGLAGQRGIVGLPGQRGE------RGFPGLPGPSGEPGKQGAPG------------ 1015

  Fly  1229 GSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGV 1293
            || |:|   |..|..|..|||||||..|.:|:.|..||||..|..|:.|.:|:.||
Zfish  1016 GS-GDR---GPPGPVGPPGLTGPAGETGREGNPGSDGPPGRDGAAGVKGERGNTGP--------- 1067

  Fly  1294 TIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQ 1358
                                ||||            |.||..|.||.:||.|.:|:||..|..|.
Zfish  1068 --------------------IGAP------------GAPGAPGAPGSVGPIGKQGDRGENGPQGP 1100

  Fly  1359 PGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNG 1423
            .|.   ||..|.:|..||||.:|::|..|..|::|.||.||..|..||||..|..||      .|
Zfish  1101 AGP---PGPAGARGMVGPQGPRGDKGEAGEAGERGQKGHRGFTGLQGLPGPPGSPGD------QG 1156

  Fly  1424 NDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGER 1488
            ..||.|..|.:|.:||.|..|:||:      .|:||.:.||||:|..|:.|..||.|.||.||.
Zfish  1157 AAGPAGPSGAKGPSGPVGPAGKDGS------NGQPGPIGPPGPRGRSGESGPVGPPGNPGPPGP- 1214

  Fly  1489 GLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGEPGAPAPAALDYL 1553
                                      |||.|    || .......||  .:.|.| |.|
Zfish  1215 --------------------------PGPPG----PG-IDMSAFAGL--SQPEKG-PDP------ 1239

  Fly  1554 TGILITRHSQSETVPACSAGHTELWTGYSLLYVDGNDYAHNQDLGSP-GSCVPRFSTLPVLSCGQ 1617
                 .|:.:::...:....| ::....:|..::|    ..:|:.|| ||     ...|..||..
Zfish  1240 -----LRYMRADEASSSLRQH-DVEVDATLKSING----QIEDIRSPDGS-----RKNPARSCRD 1289

  Fly  1618 NNVCNYASRNDKTFWLTTNAAIPMMPVENIEIRQYISRCVVCEAPANVIAVHSQTIEVPDCPNGW 1682
            ..:| :.......:|:..|.......::           |.|........|...|.::|. .|.|
Zfish  1290 LKLC-HPEWKSGDYWVDPNLGSAADAIK-----------VFCNMETGETCVKPSTPKIPR-KNWW 1341

  Fly  1683 -------EGLWIGYSFLMHTAVGNGG 1701
                   :.:|.|.|.       |||
Zfish  1342 TSKSKAQKHVWFGESM-------NGG 1360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	28/63 (44%)
		Collagen	322..380	CDD:189968	20/57 (35%)
		Collagen	413..465	CDD:189968	27/51 (53%)
		Collagen	499..561	CDD:189968	29/61 (48%)
		Collagen	574..632	CDD:189968	29/60 (48%)
		Collagen	657..714	CDD:189968	22/56 (39%)
		Collagen	765..824	CDD:189968	22/58 (38%)
		Collagen	854..911	CDD:189968	26/59 (44%)
		Collagen	884..943	CDD:189968	23/58 (40%)
		Collagen	923..982	CDD:189968	24/58 (41%)
		Collagen	1028..1085	CDD:189968	24/56 (43%)
		Collagen	1229..1287	CDD:189968	27/57 (47%)
		Collagen	1318..1376	CDD:189968	19/57 (33%)
		Collagen	1399..1458	CDD:189968	22/58 (38%)
		Collagen	1477..1534	CDD:189968	13/56 (23%)
		C4	1555..1662	CDD:128421	17/107 (16%)
		C4	1663..1777	CDD:128421	11/46 (24%)
col2a1a	NP_571367.1	VWC	38..93	CDD:278520	13/66 (20%)
		Collagen	262..336	CDD:189968	39/104 (38%)
		Collagen	372..428	CDD:189968	29/69 (42%)
		Med15	<381..>704	CDD:312941	165/424 (39%)
		Collagen	496..555	CDD:189968	30/58 (52%)
		Collagen	670..729	CDD:189968	33/72 (46%)
		PRK07764	<772..966	CDD:236090	91/201 (45%)
		Collagen	820..879	CDD:189968	28/61 (46%)
		Collagen	856..907	CDD:189968	21/52 (40%)
		Collagen	937..1010	CDD:189968	36/78 (46%)
		COLFI	1255..1490	CDD:366624	27/136 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810