DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Col4a1 and col27a1b

DIOPT Version :9

Sequence 1:NP_723044.1 Gene:Col4a1 / 33727 FlyBaseID:FBgn0000299 Length:1779 Species:Drosophila melanogaster
Sequence 2:NP_001074044.1 Gene:col27a1b / 560145 ZFINID:ZDB-GENE-100119-2 Length:1658 Species:Danio rerio


Alignment Length:1618 Identity:548/1618 - (33%)
Similarity:688/1618 - (42%) Gaps:479/1618 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 GEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKG 276
            |.|||||..|..|..|..|.||::|.||.|||:|..||                   ||.||.||
Zfish   427 GLKGEPGLPGPPGPPGQPGLPGKRGPRGPSGPHGKPGP-------------------PGTPGPKG 472

  Fly   277 EKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGR 341
            :||.|.    :.|      .|...|.||:||||                     ||||.||..||
Zfish   473 KKGNPG----ISP------GRAPSGIKGDPGLV---------------------GLPGQPGQPGR 506

  Fly   342 QGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKPGLLGPPGPPGGGRGTPGPPGPK 406
            :|..|.||.:|..||:   |:.|..|:||.||.|||.|.         |||.|.       .|||
Zfish   507 KGQKGHPGPSGHPGDQ---GIRGPDGSPGAKGYPGRQGL---------PGPIGN-------MGPK 552

  Fly   407 GPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEGPPGKKGEKGTAGLNGPKGSIGP 471
            |.||::|.||..||.|.||..|..|..|:||..|.||.||:                        
Zfish   553 GVRGFIGIPGIFGLPGADGERGLPGVPGKKGKMGRPGFPGD------------------------ 593

  Fly   472 IGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTP 536
            .|..|||||:|..|:.|.|        |..||||:      .|:.|..|..|.||  .:|..|.|
Zfish   594 FGERGPPGPDGNPGEIGAP--------GPVGIPGF------IGDMGPVGMVGPPG--LIGPKGVP 642

  Fly   537 GAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGE 601
            |..|.||.|||.|..|.||:.|:.|.:||            ||.:|:.||||:.||      ||.
Zfish   643 GNPGEPGLKGDKGELGLPGEPGEPGFQGD------------KGIQGSPGLPGVQGK------PGP 689

  Fly   602 RGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKG 666
            :|..|:||.||:.|..||         .|.||..|.||:                        .|
Zfish   690 QGKIGDRGPDGLPGPLGP---------EGFPGDIGPPGQ------------------------NG 721

  Fly   667 VQGFKGAEGLPGIPGPKGEFGFKGEK---GLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHG 728
            |:|.||..|:.|||||.|..|.:|::   |.:||||.:|.|||.|..|.||..|  :|||||..|
Zfish   722 VEGPKGNAGVRGIPGPGGLPGLEGDQGPVGPAGAPGLEGRPGRKGISGNPGEEG--MKGEPGMTG 784

  Fly   729 RDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGN 793
            ..|..|::|..|..|..||.|          ..|.||:.|:||.||||||.|:.|..|..|.:|.
Zfish   785 NPGMLGERGPVGFVGPFGEMG----------LAGEKGDRGETGQPGPPGEKGAMGHPGAPGERGL 839

  Fly   794 TGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGP 858
            :||.|.||..|.|||:|.||.||.:||.|..|..|:.|:.|:.|..|.||.:             
Zfish   840 SGPAGAPGPHGSRGLSGTRGPKGTRGARGPDGPVGEKGMMGMKGPEGPPGKQ------------- 891

  Fly   859 PGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAG 923
             ||:|..|:.|:.|..||.||.|..|..|.||.:|..|.||..|.||::|..|::|.||..|.||
Zfish   892 -GLSGQMGKIGETGEAGPTGFTGVQGPTGPPGAKGILGEPGPQGSPGVLGPLGEIGAIGLPGKAG 955

  Fly   924 PPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVS 988
            ..|:|      |..|.||..||||.:|..|..|.||.||.||..|.:|..||.|::|..|:.|.|
Zfish   956 DQGLP------GEPGEKGAVGSPGNIGEQGLIGPRGDPGVDGEAGPSGPDGAKGEQGDVGLEGES 1014

  Fly   989 GAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGP 1053
               |:||..|..|.:|..|.      |||:|:||.:   |.||:.|..|.|||||::|       
Zfish  1015 ---GEKGVIGFKGTEGRTGD------PGLIGVKGPE---GKPGKIGERGKPGEKGSKG------- 1060

  Fly  1054 PGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGR 1118
                    .:||.||.|..|.:|||                                        
Zfish  1061 --------HQGQLGEMGALGEQGDT---------------------------------------- 1077

  Fly  1119 DGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSG 1183
             |..|.||.:|..|..|.||:.|..|.||:.|..|..|..|:.|:||..|..|::||.|:  :.|
Zfish  1078 -GFIGPKGSRGTTGFMGAPGKMGQQGEPGLVGYEGHQGPQGSLGSPGPKGEKGEQGDDGK--VEG 1139

  Fly  1184 LPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGL 1248
            .||..|:.|||            |.||.||:||.|                ||.|.:|.|||||.
Zfish  1140 PPGPSGDIGPV------------GNRGDRGEPGDP----------------GYPGLEGVQGERGK 1176

  Fly  1249 TGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGL 1313
            .|..||.|..|.||..||.|:.|..   |.||...||||        .|.:|.||..|..|.:|:
Zfish  1177 EGAPGVPGNSGPRGFPGPKGSKGNK---GPKGKNSPRGE--------SGNRGSPGPVGVPGPRGV 1230

  Fly  1314 IGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQG 1378
            ||..|..||.||.|.||:.|..|:||.:   |..|:.||.|.||..|..|.||.||::|..||  
Zfish  1231 IGREGFEGEPGLDGAAGKDGAKGMPGDL---GRDGDVGLPGKPGPQGNAGAPGLPGVQGSFGP-- 1290

  Fly  1379 FKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRD 1443
                            ||:||:.|.||.||..|..|..|:||..|:.|..|.||:          
Zfish  1291 ----------------KGERGITGHSGPPGKRGLNGGMGFPGKQGDQGFKGQPGD---------- 1329

  Fly  1444 GRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGE 1508
                    .|::|.||:|...||:|.||.   .||.|..|..|.:||:|:||..|..   |:||.
Zfish  1330 --------AGEQGFPGVLGIFGPQGPPGD---FGPVGIQGPKGPQGLMGMQGAIGPV---GIIGP 1380

  Fly  1509 TGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGEPGAPAPAALDYLTGILITRHSQSETVPACSAG 1573
            :||   |||:||:|..||.|.:|..|..|.:|.||.|.                    :||.:..
Zfish  1381 SGN---PGPQGDKGNKGEMGVQGPRGPPGPRGPPGPPG--------------------LPAVAFS 1422

  Fly  1574 HTELWTGYSLLYVDGNDYAHN---QDLGSP----GSCVPRFSTLPVLS----------------- 1614
            |.....|.:|...|......:   ||...|    ||.:  |.||..||                 
Zfish  1423 HENEALGAALHVFDSRSALRSEMYQDTDLPLLDQGSEI--FKTLHYLSILIHSIKNPLGTQENPA 1485

  Fly  1615 --CGQNNVCNYASRNDKTFWLTTNAAIPMMPVENIEIR-QYISRCVVCEAP-------------- 1662
              |.....|.: ..||.|:|:..|.....   :|||:. .:.|....|..|              
Zfish  1486 RMCRDLLECEH-RLNDGTYWIDPNLGCSS---DNIEVTCSFTSGGQTCLKPVTASKLEIGVSLIQ 1546

  Fly  1663 -----------ANVIAVHSQTIEVPDCPNGWEGLWIGYSFLMHTAVGNGGGGQALQSPGSCLEDF 1716
                       ..:|.||...:.|          |               ..:..::|.|.:..|
Zfish  1547 MNFIHLLSSEAVQIITVHCLNVSV----------W---------------ASEDSKTPSSSMVYF 1586

  Fly  1717 RATP--------FIECNGAKGTC-----HFYETMTSF-----------WMYNLESSQP 1750
            :|..        |||.:..|..|     .:::|...|           .:|||.|::|
Zfish  1587 KAWDGQIIEAGGFIEPDLLKDECWITDGRWHQTQFIFRTQDPNLLPIVEIYNLPSTKP 1644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Col4a1NP_723044.1 Collagen 104..161 CDD:189968
Collagen 322..380 CDD:189968 25/57 (44%)
Collagen 413..465 CDD:189968 18/51 (35%)
Collagen 499..561 CDD:189968 26/61 (43%)
Collagen 574..632 CDD:189968 21/57 (37%)
Collagen 657..714 CDD:189968 25/59 (42%)
Collagen 765..824 CDD:189968 32/58 (55%)
Collagen 854..911 CDD:189968 23/56 (41%)
Collagen 884..943 CDD:189968 25/58 (43%)
Collagen 923..982 CDD:189968 26/58 (45%)
Collagen 1028..1085 CDD:189968 20/56 (36%)
Collagen 1229..1287 CDD:189968 25/57 (44%)
Collagen 1318..1376 CDD:189968 26/57 (46%)
Collagen 1399..1458 CDD:189968 18/58 (31%)
Collagen 1477..1534 CDD:189968 26/56 (46%)
C4 1555..1662 CDD:128421 28/133 (21%)
C4 1663..1777 CDD:128421 21/112 (19%)
col27a1bNP_001074044.1 LamG 42..214 CDD:304605
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 308..332
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 345..364
Triple-helical region 424..1417 498/1358 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 427..550 69/191 (36%)
Collagen 493..551 CDD:189968 33/97 (34%)
Collagen 523..581 CDD:189968 31/73 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 571..614 21/74 (28%)
Collagen 631..689 CDD:189968 31/77 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..1332 342/925 (37%)
Collagen 679..730 CDD:189968 28/89 (31%)
Collagen 760..819 CDD:189968 29/70 (41%)
Collagen 811..869 CDD:189968 31/57 (54%)
Collagen 874..932 CDD:189968 25/71 (35%)
Collagen 913..969 CDD:189968 26/61 (43%)
Collagen 946..1004 CDD:189968 29/63 (46%)
Collagen 985..1044 CDD:189968 28/70 (40%)
Collagen 1081..1137 CDD:189968 24/57 (42%)
Collagen 1139..1196 CDD:189968 33/84 (39%)
Collagen 1178..1235 CDD:189968 27/67 (40%)
Collagen 1226..1283 CDD:189968 27/59 (46%)
Collagen 1262..1327 CDD:189968 32/82 (39%)
Collagen 1316..1375 CDD:189968 27/79 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1377..1415 19/40 (48%)
COLFI 1459..1657 CDD:295304 39/217 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.