DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Col4a1 and col8a1a

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001135846.1	Gene:	col8a1a / 557795	ZFINID:	ZDB-GENE-070912-274	Length:	711	Species:	Danio rerio

Alignment Length:	869	Identity:	301/869 - (34%)
Similarity:	361/869 - (41%)	Gaps:	301/869 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   758 MPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVG 822
            :|...|||:..:       ||....||:|..|..|..||.||||.:||   .||:|
Zfish    60 LPMHLNKGKDNK-------GETIPRGEQGVQGQPGAQGPVGPPGPQGP---PGPQG--------- 105

  Fly   823 VPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVG 887
                   :|::|.||:.|.|||.|.|||      |.||::|:.|:.||         ||..|..|
Zfish   106 -------NGIQGPPGKPGPPGPPGYPGI------GKPGMSGMPGKAGD---------PGQPGQPG 148

  Fly   888 YPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMP 952
            ..|.||:.|.||::               ||.|..||||:|||          |:||..||.|.|
Zfish   149 EQGPRGEDGQPGIA---------------GPPGPPGPPGLPGI----------GKPGGQGLPGQP 188

  Fly   953 GNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGL 1017
            ||||:                  ||.:|..|:||:.|.|||:| .||.|:.||.|..||
Zfish   189 GNKGE------------------PGHKGFPGLPGLPGPKGDRG-IGLPGSQGPKGPVGP------ 228

  Fly  1018 MGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAG 1082
                                          |||.||.||||          .|.:||.|..||||
Zfish   229 ------------------------------PGLRGPAGLPG----------VGKTGLPGIPGPAG 253

  Fly  1083 TPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPG 1147
            .||.|||.|.|     |..|||||||.||..|..|    .|..||:||.|..|.||.||..|.||
Zfish   254 VPGKPGEPGEP-----GPEGPPGEKGPQGPQGAPG----IGSPGEKGLPGQPGTPGHKGLHGPPG 309

  Fly  1148 IPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIR 1212
            :||.||:.|.       |..||||.:||:   |:.|||               |..|||||:|..
Zfish   310 LPGKPGLPGF-------GKPGYPGPKGDR---GMGGLP---------------GPQGPKGEKGHM 349

  Fly  1213 GQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPG 1277
            |||                                              |:.||||.:||   ||
Zfish   350 GQP----------------------------------------------GMMGPPGQTGL---PG 365

  Fly  1278 AKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIG 1342
            ..|.||..||:|.||  :|||.|..|..|..|..||.|.||:.|:.|.||..||||..|..||||
Zfish   366 PSGPIGATGEVGSPG--LKGEGGAGGAKGDPGPIGLTGPPGIPGQPGQPGEDGEPGPRGPQGPIG 428

  Fly  1343 PAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLP 1407
            |   |||.|..|.||.|||.|.   |||||:|||.|.:|.|                  ||:|:|
Zfish   429 P---KGEGGSNGLPGPPGQSGL---PGLKGETGPPGPEGPR------------------GPTGIP 469

  Fly  1408 GLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGR--DGTPGLPGQKGEPGMLPPPGPKGEP 1470
            ||.|       ||  |..||.|.||.:|..||.|:.|:  :|:||:.|..|.||   ||||.|.|
Zfish   470 GLAG-------PG--GLLGPPGPPGPKGEVGPPGQAGQPGEGSPGIQGPVGPPG---PPGPNGSP 522

  Fly  1471 GQPGRNGPKGEPGRPG---ERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEGA 1532
            ||||..||.|.||.||   ...|:|:..|.|                |...|.:....:..|.|.
Zfish   523 GQPGIQGPPGPPGPPGPAPSPDLMGVLPEMG----------------PALDGVKAGYKKGKYAGE 571

  Fly  1533 IGLIGQKG-------------EPGAPAPAALDYLTGILITRHSQSETVPACS-------AGH--- 1574
            ..::|..|             .|....|..||.|.......::....|..|.       |.|
Zfish   572 GDMMGANGLEMPAFTAKLTAPFPPVGTPIVLDKLLYNGRQNYNPQTGVFTCDLPGVYYFAYHVHC 636

  Fly  1575 --TELWTGYSLLYVDGNDYAHNQD 1596
              ..:|.|   ||.:|....:..|
Zfish   637 KGANVWVG---LYRNGEPVMYTYD 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968
		Collagen	322..380	CDD:189968
		Collagen	413..465	CDD:189968
		Collagen	499..561	CDD:189968
		Collagen	574..632	CDD:189968
		Collagen	657..714	CDD:189968
		Collagen	765..824	CDD:189968	19/58 (33%)
		Collagen	854..911	CDD:189968	17/56 (30%)
		Collagen	884..943	CDD:189968	19/58 (33%)
		Collagen	923..982	CDD:189968	21/58 (36%)
		Collagen	1028..1085	CDD:189968	17/56 (30%)
		Collagen	1229..1287	CDD:189968	12/57 (21%)
		Collagen	1318..1376	CDD:189968	32/57 (56%)
		Collagen	1399..1458	CDD:189968	25/60 (42%)
		Collagen	1477..1534	CDD:189968	15/59 (25%)
		C4	1555..1662	CDD:128421	10/54 (19%)
		C4	1663..1777	CDD:128421
col8a1a	NP_001135846.1	Collagen	320..376	CDD:189968	34/122 (28%)
col8a1a	NP_001135846.1	C1Q	581..711	CDD:128420	15/80 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910