DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col24a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_038959798.1	Gene:	Col24a1 / 499723	RGDID:	1565539	Length:	1731	Species:	Rattus norvegicus

Alignment Length:	1665	Identity:	558/1665 - (33%)
Similarity:	678/1665 - (40%)	Gaps:	550/1665 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 MEGPSGDKGQKGDPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIP 175
            :.||.||.|..|.|||         .|.||..|:.|..|:.||.||||.|
  Rat   504 LRGPKGDTGPPGPPGP---------MGIPGPSGKRGPRGIPGPHGNPGLP--------------- 544

  Fly   176 GLEGLSGMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGD 240
                  |:|||         ||.||:|....|..|.||||:|   |..||.||.|..||||.:|.
  Rat   545 ------GLPGP---------KGPKGDPGLSPGQAASGEKGDP---GLLGLVGPPGLQGEKGLKGH 591

  Fly   241 SGPYGAKGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGE 305
            :                            |.||::||:|.|                |..|..|.
  Rat   592 T----------------------------GLPGLRGEQGIP----------------GLAGNVGS 612

  Fly   306 PGLVGRKGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPG 370
            ||..||:|..||||:   .|.||.:|..|.||:.|:   .||.|..|..|.||:.|..|..|.||
  Rat   613 PGYPGRQGLAGPEGN---PGSKGVRGFIGSPGEAGQ---LGPEGERGTPGVRGKKGPKGRQGFPG 671

  Fly   371 QKGEPGRAGATGKPGLLGPPGPPG--GGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYN 433
            ..|:.|.||..|.|||:|..||||  |.||..||.||.||   .|.|||.||:|..|.||.:|..
  Rat   672 DFGDRGPAGLDGSPGLVGGIGPPGFPGIRGNVGPAGPVGP---PGVPGPMGLSGSRGPPGIKGDK 733

  Fly   434 GQKGGAGLPGRPGNE------GPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGY 492
            |::|.||.||.||..      |.||..|.:|.:|.:|..|..||.|..|||||||..||.|:||.
  Rat   734 GEQGVAGEPGEPGYPGDKGAIGSPGPPGIRGKSGPSGQPGDPGPQGPTGPPGPEGFPGDIGIPGQ 798

  Fly   493 ----GIQGSKGDAGIPGYPGLKGSKGERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGT 553
                |.:|..|..|.||.|||||::||.|           .:|..|..|:.|.||:||..|.||.
  Rat   799 NGPEGPKGHLGSRGPPGPPGLKGTQGEEG-----------PIGPFGELGSRGKPGRKGYMGEPGP 852

  Fly   554 PGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTG 618
            .|.||:.|.:||:         |..|:.|..||||..|..|:.|..||||.|         |..|
  Rat   853 EGLKGETGDQGDI---------GKIGETGPVGLPGEVGITGSIGEKGERGSP---------GPLG 899

  Fly   619 PPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPK 683
            |.||||.                              .||||.|||               |||.
  Rat   900 PQGEKGV------------------------------MGYPGPPGA---------------PGPM 919

  Fly   684 GEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEP 748
            |..|..|..|..||||:.|.                 ||:.|..|.||..||:|..|
  Rat   920 GPIGLPGLVGARGAPGSPGP-----------------KGQRGPRGPDGLAGDQGGHG-------- 959

  Fly   749 GSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRG 813
                       |||.||..|:.|:||..|:.|||||||.
  Rat   960 -----------AKGEKGNQGKRGLPGRAGKTGSPGERGV-------------------------- 987

  Fly   814 EKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIG 878
                         .||.||:|:||.:|..||.||     |||.|.||..||.||.|..||
  Rat   988 -------------QGKPGLQGLPGSSGDMGPAGE-----PGPRGLPGDAGLPGEMGVEGP----- 1029

  Fly   879 FPGADGSVGYPGDRGDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEP 943
                      ||..||:||.|..|..|.||..|..|..|..|..|.||.||.:|::|:||.||.|
  Rat  1030 ----------PGTEGDSGLQGEPGAKGDVGPTGSEGATGEPGPRGEPGAPGEEGLQGKDGLKGAP 1084

  Fly   944 GSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGG 1008
            |..||.|..|.||:.|.||..||.|..|..|.||..|..|.||..|..|.||..|.||..|..|.
  Rat  1085 GGSGLPGEDGEKGEMGLPGTAGPVGRPGQMGPPGSEGIVGTPGERGRTGKKGDKGQTGPVGEAGS 1149

  Fly  1009 RGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSG 1073
            ||.||..|..|.||.:|..||.|..||.|..||            ||:||   .:|.:|:|||||
  Rat  1150 RGSPGRVGDSGPKGARGTRGAVGPLGLMGPEGE------------PGIPG---YRGLEGQPGPSG 1199

  Fly  1074 LRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPG 1138
            |   .||.|..|:|||....       .||||.:|:.            |..||:|.:|..|:.|
  Rat  1200 L---PGPKGEKGYPGEDSTV-------LGPPGPRGEP------------GPMGERGERGEHGEEG 1242

  Fly  1139 EKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAP 1203
            .||.:|.||:.||.|..|.||.         |||:|::         |||||.|..|.||..|.|
  Rat  1243 YKGHMGVPGLRGAAGQQGPPGE---------PGDQGEQ---------GLKGERGSEGPQGKKGVP 1289

  Fly  1204 GPKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPG 1268
            ||.|:.||.|.||||                                        |.:||||..|
  Rat  1290 GPSGKPGIPGLPGLP----------------------------------------GPKGLQGYHG 1314

  Fly  1269 ASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPG 1333
            ..||:|.||..|              :.|::||||..|..||.||.|:|   |.:|..|.:|.||
  Rat  1315 VDGLSGYPGKPG--------------LLGKQGLPGTTGSPGRTGLAGSP---GPQGGKGSSGPPG 1362

  Fly  1334 LVGLPGPIGPAGSKGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDR 1398
            ..|:|||      |||:||.|.||.|||         :|..|.||.:|.||..|.:||.|:.|::
  Rat  1363 SPGVPGP------KGEQGLPGQPGIPGQ---------RGQRGTQGDQGRRGEPGLKGQPGEHGNQ 1412

  Fly  1399 GLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPP 1463
            ||.|..|.||..|.:||.|..|:.|..|||   |:||.|||.||:
  Rat  1413 GLTGFQGFPGPRGPEGDAGIIGIVGPKGPV---GQRGNTGPLGRE-------------------- 1454

  Fly  1464 PGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERG 1528
                                     |:||..|..|.:||:|..|||      ||:|.||:|
  Rat  1455 -------------------------GIIGPTGGTGPRGEKGFRGET------GPQGPRGQP---- 1484

  Fly  1529 YEGAIGLIGQKGEPGAPAPAA---LDYLTGILITRHS-------QSETVPACSAGHTELWTGYSL 1583
                    |..|.||||.|..   ::...|.||..:|       |:..|...|.| ||:  ..:|
  Rat  1485 --------GPPGPPGAPGPRRQMDINAAIGALIESNSAQQMESYQNTEVTFLSQG-TEI--SKTL 1538

  Fly  1584 LYVDGNDYAHNQDLGSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTN------------ 1636
            .|:.....:....||:..:        |...|.....|.| ..:|..:|:..|
  Rat  1539 AYLSSLLSSIKNPLGTREN--------PARICKDLLSCQY-EVSDGKYWIDPNLGCSSDAFEVFC 1594

  Fly  1637 -------AAIPMMPVENIE-----IRQYISRCVVCEAPANVIAVH--------SQTIEVPDCP-- 1679
                   ..:..:.|..:|     ::......:..|| .::|.:|        ....:.|:.|
  Rat  1595 NFSAGGQTCVSPVSVTKLEFGVGKVQMNFLHLLSSEA-THIITLHCLNTPRRTGTPADGPELPIS 1658

  Fly  1680 -NGW-----------------------EGLWIGYSFLMHT 1695
             .||                       :|.|....||.||
  Rat  1659 FKGWNGQIFEENTLLEPQVLSDDCKIQDGSWHKAKFLFHT 1698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	21/49 (43%)
		Collagen	322..380	CDD:189968	23/57 (40%)
		Collagen	413..465	CDD:189968	25/57 (44%)
		Collagen	499..561	CDD:189968	26/61 (43%)
		Collagen	574..632	CDD:189968	22/57 (39%)
		Collagen	657..714	CDD:189968	19/56 (34%)
		Collagen	765..824	CDD:189968	13/58 (22%)
		Collagen	854..911	CDD:189968	23/56 (41%)
		Collagen	884..943	CDD:189968	26/58 (45%)
		Collagen	923..982	CDD:189968	30/58 (52%)
		Collagen	1028..1085	CDD:189968	23/56 (41%)
		Collagen	1229..1287	CDD:189968	12/57 (21%)
		Collagen	1318..1376	CDD:189968	22/57 (39%)
		Collagen	1399..1458	CDD:189968	23/58 (40%)
		Collagen	1477..1534	CDD:189968	17/56 (30%)
		C4	1555..1662	CDD:128421	24/137 (18%)
		C4	1663..1777	CDD:128421	12/67 (18%)
Col24a1	XP_038959798.1	LamG	41..227	CDD:419873
		Collagen	528..590	CDD:396114	35/94 (37%)
		Collagen	575..629	CDD:396114	29/100 (29%)
		Collagen	605..660	CDD:396114	26/60 (43%)
		Collagen	638..687	CDD:396114	22/51 (43%)
		Collagen	720..769	CDD:396114	20/48 (42%)
		Collagen	845..900	CDD:396114	26/72 (36%)
		Collagen	929..985	CDD:396114	30/91 (33%)
		PHA03169	958..>1112	CDD:223003	83/231 (36%)
		Collagen	1115..1171	CDD:396114	26/55 (47%)
		Collagen	1157..1212	CDD:396114	30/72 (42%)
		Collagen	1245..1301	CDD:396114	31/73 (42%)
		Collagen	1275..1330	CDD:396114	30/108 (28%)
		Collagen	1374..1430	CDD:396114	28/64 (44%)
		COLFI	1548..1730	CDD:413320	25/161 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910