DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and col1a1

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001011005.1	Gene:	col1a1 / 496414	XenbaseID:	XB-GENE-6258379	Length:	1449	Species:	Xenopus tropicalis

Alignment Length:	1510	Identity:	578/1510 - (38%)
Similarity:	669/1510 - (44%)	Gaps:	367/1510 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLYAAVIAGALVGADAQFWKTAGTAGSIQ--DSVKH---YNRNEPKFPIDDSYDIVDSAGV---- 63
            |:.|.::.....|.|           .:|  |.|:|   ||..:...|.:....:.|:..:
Frog    12 LIAATILVARCQGED-----------DVQDYDCVQHGIRYNNKDVWKPEECQICVCDNGNILCDE 65

  Fly    64 ---ARGDLPPKNCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMGF---PGMEGPSGDKGQKG 122
               ...|.|......|  .|.|.||   ||              :..|   .|:|||      ||
Frog    66 VICEDADCPDPKMVQG--ECCPMCI---GN--------------DAQFSEVTGVEGP------KG 105

  Fly   123 DPGPYGQRGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGING------KDGCDGQDGIPGLEGLS 181
            |.||   |||:|..|.||..|..|.||:.||.|.||.||:.|      ..|.|.:..     |:|
Frog   106 DIGP---RGDRGPAGPPGRDGIPGQPGIPGPPGPPGPPGLGGNFAPQMSYGYDEKSA-----GVS 162

  Fly   182 GMPGPRGYAGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGA 246
             ||||.|..|..|..|..|.|                        |||||.|..||.|:.|..||
Frog   163 -MPGPMGPMGPRGPPGPSGSP------------------------GPQGFQGPPGEPGEPGSSGA 202

  Fly   247 KGPRGEHGLKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGR 311
            .||||                ..|.||..||.||                      .|:||..|.
Frog   203 MGPRG----------------PAGPPGKNGEDGE----------------------AGKPGRPGE 229

  Fly   312 KGEPGPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPG 376
            :|.|||:|..||   .|..||||..|.||..      |..|.|||.|..|..|.||:||:.|.||
Frog   230 RGPPGPQGARGL---PGTAGLPGMKGHRGFN------GLDGAKGDSGPAGPKGEPGSPGENGAPG 285

  Fly   377 RAGATGKPGLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGL 441
            :.|..|.|          |.||.|||.||.|.||.            ||.||..|.||..|.||.
Frog   286 QVGPRGLP----------GERGRPGPSGPAGARGN------------DGAPGGAGPNGPTGPAGP 328

  Fly   442 PGRPGNEGPPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGY 506
            ||.||..               ||||..||.|..||.||:|.:|:.|.||..  |:.|.:|.||.
Frog   329 PGFPGGV---------------GPKGDAGPQGSRGPDGPQGGRGEPGAPGQA--GAAGPSGNPGS 376

  Fly   507 PGLKGSKGERGFKGNAGAPG-DSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKC 570
            .|..|:||..|..|.||||| ....|.||..|..||||.||:.|.||..|.||:.|.||:.|...
Frog   377 DGQAGAKGATGAPGIAGAPGFPGARGAPGPQGPGGAPGPKGNNGEPGAQGNKGEPGAKGESGPAG 441

  Fly   571 SSCRAGPKGDKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGAT 635
            .....||.|::|..|..|.||..|..||.||||.||.||..|.:|.:||.|..||.|..|..||.
Frog   442 VQGPPGPSGEEGKRGSRGEPGPAGPPGPAGERGAPGSRGFPGSDGASGPKGGPGERGPVGPAGAK 506

  Fly   636 GEPGKPALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGN 700
            |.||:            .|..|.||.|||||:      .|.||.|||      .|:.|.:||||.
Frog   507 GSPGE------------SGRPGEPGLPGAKGL------TGSPGSPGP------DGKTGPAGAPGQ 547

  Fly   701 DGTPGRAGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKG 765
            ||.||..|.   ||..|||  |..||.|..||.|:.|..|..|..|.||          |.|..|
Frog   548 DGRPGPPGP---PGARGQS--GVMGFPGPKGAAGEPGKSGERGVAGPPG----------AVGLPG 597

  Fly   766 EPGQTGMPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKD 830
            :.|..|..||||..|..|||      |..||.|.||.:|..|..||.||.|..|..||||:.|..
Frog   598 KDGDAGAQGPPGPAGPSGER------GEQGPAGGPGFQGLPGPPGPAGESGKPGEQGVPGDVGPS 656

  Fly   831 GLRGIPGRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGS---VGYPGDR 892
            |..|..|..|.||.||..|  .|||.||.|.||..|..|.:|..|..|.||..|.   .|.||:|
Frog   657 GPAGARGERGFPGERGAQG--PPGPQGPRGSNGAPGNDGAKGEAGASGAPGGQGPPGLQGMPGER 719

  Fly   893 GDAGLPGVSGRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGD 957
            |..||||..      |::||      .||.|..|.||.|||||..|..|.|| ||  |.||:||:
Frog   720 GAGGLPGAK------GDRGD------QGVKGSDGAPGKDGVRGLTGPIGPPG-PG--GAPGDKGE 769

  Fly   958 RGAPGNDGPKGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKG 1022
            .|..|..||   .|..||||:||.:|.|                  ||.|..|||||.|..|.||
Frog   770 AGPAGPAGP---TGARGAPGERGESGPP------------------GPAGFAGPPGADGQPGAKG 813

  Fly  1023 DQGLAGAPGQQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWP 1087
            :||.|||            ||:.|.||..||.|.||.|   |..|..||.|.||..||.|..|:|
Frog   814 EQGDAGA------------KGDAGPPGPAGPTGAPGPA---GALGATGPKGARGAPGPPGATGFP 863

  Fly  1088 GEKGLPGLAVHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAP 1152
            |        ..||.||||..|:.|..|..|..|..|.||.:|..|..|:|||.|:.|..|.||..
Frog   864 G--------ATGRVGPPGPAGNSGPPGPSGPAGKEGAKGPRGETGPAGRPGEPGAAGPAGPPGEK 920

  Fly  1153 GMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGL 1217
            |..|..|.||||   |.||.:|..|..|..||||::||      :||:|.|||.||
Frog   921 GSPGSDGPAGAP---GIPGPQGVAGSRGTVGLPGMRGE------RGFSGLPGPVGE--------- 967

  Fly  1218 PATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDI 1282
                         .|::|.:|..||:|..|.:||.|:||..|:.|.:|.||:   .|.||..|..
Frog   968 -------------PGKQGPSGPSGERGPPGPSGPPGLAGPPGEAGREGAPGS---EGAPGRDGAA 1016

  Fly  1283 GPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSK 1347
            ||:|:        :||.|..|.|                        |.||..|.|||:||||..
Frog  1017 GPKGD--------RGEGGPAGPP------------------------GAPGAPGAPGPVGPAGKS 1049

  Fly  1348 GERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQ 1412
            |:||..|..|..|..|..||   :|..||||.:|::|..|.:|::|.||.||..||:|.|
Frog  1050 GDRGETGPAGPAGPAGVAGA---RGPAGPQGPRGDKGEAGEQGERGMKGHRGFNGPAGPP----- 1106

  Fly  1413 KGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNG 1477
                |.||.:|..||.||.|.   .||:|..|..|.||..|..|.||.:.||||:|..|..|..|
Frog  1107 ----GPPGSSGEQGPSGASGP---AGPRGPPGSSGNPGKDGANGLPGPIGPPGPRGRTGDVGPAG 1164

  Fly  1478 PKGEPGRPGERGLIG 1492
            |.|.||.||..|..|
Frog  1165 PPGPPGPPGPPGASG 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	26/59 (44%)
		Collagen	322..380	CDD:189968	25/57 (44%)
		Collagen	413..465	CDD:189968	14/51 (27%)
		Collagen	499..561	CDD:189968	31/62 (50%)
		Collagen	574..632	CDD:189968	28/57 (49%)
		Collagen	657..714	CDD:189968	25/56 (45%)
		Collagen	765..824	CDD:189968	26/58 (45%)
		Collagen	854..911	CDD:189968	25/59 (42%)
		Collagen	884..943	CDD:189968	26/61 (43%)
		Collagen	923..982	CDD:189968	31/58 (53%)
		Collagen	1028..1085	CDD:189968	23/56 (41%)
		Collagen	1229..1287	CDD:189968	23/57 (40%)
		Collagen	1318..1376	CDD:189968	21/57 (37%)
		Collagen	1399..1458	CDD:189968	23/58 (40%)
		Collagen	1477..1534	CDD:189968	9/16 (56%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
col1a1	NP_001011005.1	VWC	33..87	CDD:278520	11/55 (20%)
		Collagen	222..281	CDD:189968	31/67 (46%)
		Collagen	258..311	CDD:189968	29/74 (39%)
		Collagen	342..401	CDD:189968	28/60 (47%)
		Collagen	468..521	CDD:189968	28/64 (44%)
		Collagen	498..550	CDD:189968	29/75 (39%)
		Collagen	769..822	CDD:189968	30/85 (35%)
		Collagen	846..903	CDD:189968	27/64 (42%)
		COLFI	1215..1448	CDD:279718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910