DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and Col4a3

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	XP_038939824.1	Gene:	Col4a3 / 363265	RGDID:	71085	Length:	1671	Species:	Rattus norvegicus

Alignment Length:	1817	Identity:	794/1817 - (43%)
Similarity:	955/1817 - (52%)	Gaps:	281/1817 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PP---KNCTA-GYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQ 129
            ||   |.|.. |...|:  |...||.:|..|..||.|..|:.||||.||..|.:|.||.||..|.
  Rat    24 PPVVSKGCVCEGKGKCL--CWGTKGEKGEIGFPGPPGFPGQKGFPGPEGLPGPQGPKGSPGLPGL 86

  Fly   130 RGDKGERGSPGLHGQAGVPGVQGPAGNPGAPGINGKDGCDGQDGIPGLEGLSGMPGPRGYAGQLG 194
            .|.||.||..||.|.||.||:.|..|.||.||:.|..||:|..|..|..|:.|.||..|..|..|
  Rat    87 TGPKGIRGITGLPGFAGPPGLPGIPGYPGPPGLAGLPGCNGSKGEQGFPGIPGTPGYAGLPGPDG 151

  Fly   195 SKGEKGEPAK-ENGDY-AKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHGLKG 257
            .||:||:||: |:|:: .||:.|.||..|..||.||.||||..|..|..|.:|..|..|..|.||
  Rat   152 LKGQKGKPAQGEDGEFNGKGDPGPPGAPGFQGLPGPPGFPGPAGPPGPPGFFGFPGAMGPRGPKG 216

  Fly   258 EKGASCYGPMKPGAPGIKGEKGEPASSFPVKPT-------HTVMGPRGDMGQKGEPGLVGRKGEP 315
            ..|.|..|  :.|..|:||..|.|....||..|       ....|.:||.|::|||      |.|
  Rat   217 RMGDSTIG--QEGEKGVKGLTGPPGLPGPVIFTLRHPYRKSDFQGQKGDEGERGEP------GPP 273

  Fly   316 GPEGDTGLDGQKGEKGLPGGPGDRGRQGNFGP---PGSTGQKGDRGEPGLNGLPGNPGQKGEPGR 377
            ||.|..| |....|||.||.||.||:.|..|.   ||:.|.||.||.|||.|..|..|.||:
  Rat   274 GPSGPPG-DSYGSEKGAPGEPGPRGKPGKDGAPGFPGTEGAKGTRGFPGLRGEAGIKGWKGD--- 334

  Fly   378 AGATGKPGLLGPPGPPG------------GGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQ 430
                     :||||.||            |.:|.||||||||.|      ||:|.:|..|:||..
  Rat   335 ---------IGPPGFPGPTEECYDAHLQKGDKGMPGPPGPKGVR------GPRGPSGPPGVPGSP 384

  Fly   431 GYNGQKGGAGLPGRPGNEGP------PGKKGEKGTAGLN--GPKGSIGPIGHPGPPGPEGQKGDA 487
            |          |.|||..||      .|.|||:|..|::  ||.||:|..|.||||||.|..|..
  Rat   385 G----------PSRPGLRGPVGWPGLKGSKGERGPPGIDTVGPPGSLGCPGSPGPPGPPGPPGRP 439

  Fly   488 G----LPG-YGIQGSKGDAGIPGYPGLKGSKGERG--------FKGNAGAPGDSKL-GRPGTPGA 538
            |    .|| .|..|:.||.|.||.||:.|.|||.|        ..|..|.||...| |..|.||.
  Rat   440 GDTVFQPGPPGDHGAPGDIGPPGVPGVDGPKGEPGQPCTECHCIPGPPGVPGVPGLDGVKGIPGG 504

  Fly   539 AGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKGDKGTSGLP----GIPGKDGARGPP 599
            .||||.||:.|.||..|..|..|..||.|      ..|.|||||.:.||    |.||..|.||.|
  Rat   505 RGAPGVKGNPGSPGNAGLPGFAGFPGDQG------HPGLKGDKGDTPLPWGQVGDPGDPGHRGLP 563

  Fly   600 GERGYPGERGHDGINGQTGPPGE------KGEDGRTGLPGATGEPGKPALCDLSLIEPLKGDKGY 658
            |.:|:.|..|..|..|..||.||      ||:.|..|.||:.|.|| ||           |..|.
  Rat   564 GRKGFDGSPGGPGAKGPRGPRGEPALSGRKGDQGPPGAPGSPGPPG-PA-----------GPAGP 616

  Fly   659 PGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLS----GAPGNDGTPGRAGRDGYPGIPGQS 719
            ||. |.:|..|.|||:|:||..||.||.|.|||...|    |.||..|.||:||..|.||:||..
  Rat   617 PGY-GPQGEPGPKGAQGVPGALGPPGEAGLKGESSASIPVLGPPGPPGPPGQAGPRGLPGLPGPV 680

  Fly   720 IKGEPGFHGRDGAK-----GDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGED 779
            ...:||..|.||..     |..|:.|..|::|.||:..|          .|.||:||.||.|||.
  Rat   681 GTCDPGHPGPDGEPGIPEVGFPGARGPKGDQGFPGTIGL----------PGYPGETGRPGYPGEM 735

  Fly   780 GSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGL---RGIPGRNGQ 841
            |.||.:|...: |..|..|.||..|.||.:|..|:.|..|..|.||.|||||.   .|.||::|.
  Rat   736 GVPGAKGEPSV-GRPGEPGKPGFPGERGNSGENGDIGLPGLPGPPGTPGKDGFDGPPGDPGQSGP 799

  Fly   842 PGPRGEPGISRPGPMGP---PGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGR 903
            ||.:|.||...|||.|.   ||||||:|:.|.||.|||               :||.|:||:. |
  Rat   800 PGAKGPPGRCIPGPRGTQGLPGLNGLKGQPGRRGDTGP---------------KGDPGIPGMD-R 848

  Fly   904 PGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKG 968
            .|:.||:            ||||.||:.|..|..|.||.||.||..|:||.||:.|..|..|..|
  Rat   849 SGVPGER------------GPPGTPGLPGEMGPPGQKGYPGPPGFPGLPGEKGEVGIMGYPGTTG 901

  Fly   969 FAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQ 1033
            ..|:.|.||.:|..|..|:.|.||::|..|:.|..|..|..|||.||.|.|.||:      ||.:
  Rat   902 LPGLPGKPGSQGQRGNLGIPGVKGERGRPGVKGERGEKGKPGPPHAPHLKGDKGE------PGLK 960

  Fly  1034 GLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPG-LAV 1097
            |..|.||||||:|.|||.||.||.|   ..|..|.|||   |||||.:|.||.||.:|||| :..
  Rat   961 GFVGNPGEKGNRGNPGLPGPKGLEG---VPGLPGSPGP---RGDTGSSGDPGRPGPQGLPGSMGN 1019

  Fly  1098 HGRAGPPGEKGDQGRSGIDGRDGI------NGEKGEQGL-----------QGVWGQPGEKGSVGA 1145
            .|..||.|.||..|..|:.||.|:      .|:|||.|.           :|..|.||:||..|.
  Rat  1020 MGVPGPKGRKGTSGFPGVAGRPGLPGIPGPQGDKGEPGYSEGASPGPPGPKGDPGLPGDKGKKGE 1084

  Fly  1146 PGIPGAP------GMDGLPGAAGAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPG 1204
            .|:||.|      |.||.||:.|:||..|.||..||.|..|..|.||..|.|||.|..|..|.||
  Rat  1085 RGLPGPPGHSGPAGPDGAPGSPGSPGHPGRPGPDGDSGLKGQKGFPGPPGSTGPPGPPGLPGLPG 1149

  Fly  1205 PKGERGIRGQPGLPATVPDIRGDKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGA 1269
            |.|.||.:||.|:|          |..||:|.||..|  ...|..|..||.|.|||||:   ||.
  Rat  1150 PMGMRGDQGQDGIP----------GPPGEKGETGLLG--AHPGQKGSPGVPGVKGDRGV---PGL 1199

  Fly  1270 SGLNGIPGAKGDIGPRGEIGYPGVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGL 1334
            |||.|..|..||:||:|.   ||.|     ||||.||..|..    .||..|.||||||.|.||.
  Rat  1200 SGLPGRKGTMGDVGPQGP---PGTT-----GLPGPPGLPGTI----VPGPKGNRGLPGLRGNPGE 1252

  Fly  1335 VGLPGPIGPAGS--KGERGLAGSPGQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGD 1397
            .|.|||.||.|.  ||::|..|.||.      .|.||:.||||..|..|..|:.|..|.:||.|.
  Rat  1253 PGPPGPPGPVGEGIKGDKGFMGLPGS------RGLPGMVGDTGAPGQPGAPGIPGLPGVRGDPGF 1311

  Fly  1398 RGLQGPSGLPGLVGQKGDTGYPGLNGNDGPVGAPGERGFTGPKGRDGR------DGTPGLPGQKG 1456
                  .|.||:.|:||:.|:.|..|:.|||   |.:|..||:|:.|.      .|:||.||..|
  Rat  1312 ------PGFPGVKGEKGNPGFLGSIGHPGPV---GPKGPPGPQGKPGTLKVISLPGSPGPPGAPG 1367

  Fly  1457 EPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDR 1521
            :||:...|||.|.||.||..||:|:||:.|:.|..|..|.:|.||.:|..|..|..|.||.|
  Rat  1368 QPGVKGDPGPLGPPGIPGPCGPRGQPGKDGKPGAPGPPGVKGSKGSKGEQGPPGLDGLPGLK--- 1429

  Fly  1522 GEPGERGYEGAIGLIGQKGEPGAPAPAALDYLTGILITRHSQSETVPACSAGHTELWTGYSLLYV 1586
            |:||:||                 .||....:.|.:.|||||:...|:|..|...|::|:|||:|
  Rat  1430 GKPGDRG-----------------TPANGTRMRGFIFTRHSQTTANPSCPEGTQPLYSGFSLLFV 1477

  Fly  1587 DGNDYAHNQDLGSPGSCVPRFSTLPVLSCGQNNVCNYASRNDKTFWLTTNAAIP--MMPVENIEI 1649
            .||::||.||||:.|||:.||:|:|.|.|..:||||:|||||.::||:|.|.:|  |.|:....:
  Rat  1478 QGNEHAHGQDLGTLGSCLQRFTTMPFLFCNVDNVCNFASRNDYSYWLSTPAPMPMDMAPITGRAL 1542

  Fly  1650 RQYISRCVVCEAPANVIAVHSQTIEVPDCPNGWEGLWIGYSFLMHTAVGNGGGGQALQSPGSCLE 1714
            ..|:|||.|||.||..|||||||..:|.||.||..||.|:||:|.|:.|:.|.||||.|||||||
  Rat  1543 EPYVSRCTVCEGPAMAIAVHSQTTAIPPCPQGWVSLWKGFSFVMFTSAGSEGAGQALASPGSCLE 1607

  Fly  1715 DFRATPFIECNGAKGTCHFYETMTSFWMYNLESSQPFERPQQQTIKAGERQSHVSRCQVCMK 1776
            :|||:|||||:| :|||::|....|||:.:|...:.|.:|...|:|||:.:..:||||||||
  Rat  1608 EFRASPFIECHG-RGTCNYYSNSYSFWLASLNPERMFRKPIPSTVKAGDLEKIISRCQVCMK 1668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	30/56 (54%)
		Collagen	322..380	CDD:189968	28/60 (47%)
		Collagen	413..465	CDD:189968	20/59 (34%)
		Collagen	499..561	CDD:189968	32/70 (46%)
		Collagen	574..632	CDD:189968	29/67 (43%)
		Collagen	657..714	CDD:189968	30/60 (50%)
		Collagen	765..824	CDD:189968	27/58 (47%)
		Collagen	854..911	CDD:189968	25/59 (42%)
		Collagen	884..943	CDD:189968	20/58 (34%)
		Collagen	923..982	CDD:189968	29/58 (50%)
		Collagen	1028..1085	CDD:189968	30/56 (54%)
		Collagen	1229..1287	CDD:189968	28/57 (49%)
		Collagen	1318..1376	CDD:189968	30/59 (51%)
		Collagen	1399..1458	CDD:189968	24/64 (38%)
		Collagen	1477..1534	CDD:189968	24/56 (43%)
		C4	1555..1662	CDD:128421	55/108 (51%)
		C4	1663..1777	CDD:128421	64/114 (56%)
Col4a3	XP_038939824.1	Collagen	286..339	CDD:396114	28/64 (44%)
		PRK14959	<629..>755	CDD:184923	57/136 (42%)
		Collagen	904..958	CDD:396114	24/59 (41%)
		Collagen	952..1008	CDD:396114	35/67 (52%)
		Collagen	982..1036	CDD:396114	29/59 (49%)
		Collagen	1080..1129	CDD:396114	21/48 (44%)
		Collagen	1274..1328	CDD:396114	25/65 (38%)
		C4	1447..1553	CDD:396133	52/105 (50%)
		C4	1557..1667	CDD:396133	60/110 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3842
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1348	1.000	Inparanoid score	I128
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D41315at33208
OrthoFinder	1	1.000	-	-		FOG0000443
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100768
Panther	1	1.100	-	-	O	PTHR24023
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1239
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970