DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Col4a1 and col-135

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_001255859.1	Gene:	col-135 / 3565413	WormBaseID:	WBGene00000708	Length:	660	Species:	Caenorhabditis elegans

Alignment Length:	922	Identity:	329/922 - (35%)
Similarity:	392/922 - (42%)	Gaps:	326/922 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 IPGKDGARGPPGERGYPGERGHDGINGQTGPPGEKGEDGRTGLPGATGEPGKPALCDLSLIEPLK 653
            :||..|..||||..  .|:.|..|.||:.|.||:||:         ||:               |
Worm    59 LPGPPGPPGPPGTG--TGKDGVPGTNGKDGTPGDKGD---------TGD---------------K 97

  Fly   654 GDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGRAGRDGYPGIPGQ 718
            ||||..||||.                            |:.|.||..|.||..|:||..|.||.
Worm    98 GDKGDTGAPGV----------------------------GVKGDPGAQGPPGEKGKDGDKGAPGA 134

  Fly   719 SIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTGMPGPPGEDGSPG 783
            .     |..|.||.||||||.|..||||.||.          ||:|||.|:.|..|.||..|..|
Worm   135 K-----GSKGDDGKKGDKGSSGEKGEKGSPGQ----------KGDKGEKGEKGSNGSPGSKGDKG 184

  Fly   784 ERGYTGLKGNTGPQGPPGVEGPRGLN---GPRGEKGNQGAVGVPGNPGKDGLRGIPGRNGQPGPR 845
            |:   |..||.||:|..|.:|.:|.:   |.:|:||:.||.|..||||..|..|..|..|..|.:
Worm   185 EK---GADGNPGPKGDKGADGAKGADGTPGSKGDKGSDGAKGADGNPGSKGDTGDKGEKGSDGAK 246

  Fly   846 GEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVSGRPGIVGEK 910
            |:           .|.||..|.|||:|..|..|..||||:   ||.:||.|..|..|..|..|:|
Worm   247 GD-----------KGANGTPGSKGDKGEKGADGAKGADGT---PGSKGDKGADGAKGADGTPGQK 297

  Fly   911 GDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGPKGFAGVTGA 975
            ||                  .|.:|.||.||:.|:.|..|..|:|||:||   ||.|   |..|.
Worm   298 GD------------------KGEKGLDGPKGDKGADGTPGAKGDKGDKGA---DGAK---GADGT 338

  Fly   976 PGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPGQQGLDGMPG 1040
            ||.:|..|..|:.|.||||||      ||..|..|.|||      |||:|..|..|.:|.||.||
Worm   339 PGSKGDKGEKGLDGPKGDKGA------DGAKGANGTPGA------KGDKGEKGTDGAKGADGTPG 391

  Fly  1041 EKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLAVHGRAGPPG 1105
            .||::|..|||||                     :||.|..||||..|:|
Worm   392 AKGDKGEKGLDGP---------------------KGDKGADGTPGAKGDK--------------- 420

  Fly  1106 EKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAAGAPGAVGYP 1170
                                            ||||:.||.|..|.||..|..||.||.||.|.|
Worm   421 --------------------------------GEKGADGAKGADGTPGSKGDKGADGAKGADGTP 453

  Fly  1171 GDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRGDKGSQGERG 1235
            |.:|||||.||.                     ||||::|..|.||       .:|||
Worm   454 GQKGDKGEKGLD---------------------GPKGDKGADGTPG-------AKGDK------- 483

  Fly  1236 YTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYPGVTIKGEKG 1300
              ||||..|.:|..|..|..|.|||:||.||.|..|.:|.||:|||.|.:|:||.|
Worm   484 --GEKGADGAKGADGTPGSKGDKGDKGLDGPKGDKGADGTPGSKGDKGEKGDIGQP--------- 537

  Fly  1301 LPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSPGQPGQDGFP 1365
                                                     |..|.|||:|..|.|||.||||.|
Worm   538 -----------------------------------------GQKGDKGEKGQDGQPGQKGQDGQP 561

  Fly  1366 GAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGLNGN---DGP 1427
                                    ||||||||:| ||..|..|..||||..|.||..|:   .|.
Worm   562 ------------------------GQKGDKGDKG-QGEKGQDGQPGQKGQDGQPGQKGDKGEKGD 601

  Fly  1428 VGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPGERGLIG 1492
            :|.||::|..|.||:||:      |||||:.|.   ||.||:.||||:.|.|||.|.
Worm   602 IGQPGQKGDKGDKGQDGQ------PGQKGQDGQ---PGQKGQDGQPGQKGDKGEKGE-------- 649

  Fly  1493 IQGERGEKGERG 1504
             :||:||||::|
Worm   650 -KGEKGEKGQKG 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968
		Collagen	322..380	CDD:189968
		Collagen	413..465	CDD:189968
		Collagen	499..561	CDD:189968
		Collagen	574..632	CDD:189968	17/42 (40%)
		Collagen	657..714	CDD:189968	15/56 (27%)
		Collagen	765..824	CDD:189968	26/61 (43%)
		Collagen	854..911	CDD:189968	23/56 (41%)
		Collagen	884..943	CDD:189968	19/58 (33%)
		Collagen	923..982	CDD:189968	23/58 (40%)
		Collagen	1028..1085	CDD:189968	20/56 (36%)
		Collagen	1229..1287	CDD:189968	25/57 (44%)
		Collagen	1318..1376	CDD:189968	15/57 (26%)
		Collagen	1399..1458	CDD:189968	28/61 (46%)
		Collagen	1477..1534	CDD:189968	12/28 (43%)
		C4	1555..1662	CDD:128421
		C4	1663..1777	CDD:128421
col-135	NP_001255859.1	Collagen	154..211	CDD:189968	28/69 (41%)
		Collagen	205..263	CDD:189968	25/68 (37%)
		Collagen	238..296	CDD:189968	26/71 (37%)
		Collagen	313..371	CDD:189968	31/69 (45%)
		Collagen	364..422	CDD:189968	33/131 (25%)
		Collagen	397..455	CDD:189968	34/125 (27%)
		Collagen	436..494	CDD:189968	34/94 (36%)
		Collagen	511..568	CDD:189968	35/130 (27%)
		Collagen	579..638	CDD:189968	30/67 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I1466
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100768
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810