DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Col4a1 and col1a1a

DIOPT Version :9

Sequence 1:	NP_723044.1	Gene:	Col4a1 / 33727	FlyBaseID:	FBgn0000299	Length:	1779	Species:	Drosophila melanogaster
Sequence 2:	NP_954684.1	Gene:	col1a1a / 337158	ZFINID:	ZDB-GENE-030131-9102	Length:	1447	Species:	Danio rerio

Alignment Length:	1801	Identity:	622/1801 - (34%)
Similarity:	747/1801 - (41%)	Gaps:	488/1801 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLYAAVIAGALVGADAQFWKTAGTAGSIQDSVKHYNRNEPKFPIDDSYDIVDSAGVA-------- 64
            ||.|.|:.....|.|.:      |.||.....:.||..:...|......:.||..|.
Zfish    12 LLNATVLLARGQGEDDR------TGGSCTLDGQVYNDRDVWKPEPCQICVCDSGTVMCDEVICED 70

  Fly    65 RGDLPPKNCTAGYAGCVPKCIAEKGNRGLPGPLGPTGLKGEMGFPGMEGPSGDKGQKGDPGPYGQ 129
            ..|.|  |....:..|.|.|..:                 :...|.:|||      :|.||..|:
Zfish    71 TSDCP--NPVIAHDECCPVCPDD-----------------DFQEPSVEGP------RGSPGDKGE 110

  Fly   130 RGDKGERGSPGLHGQAGVP---GVQGPAGNPG--APGINGKDGCDGQDGIPGLEGLSGMPGPRGY 189
            ||.....|:.|:|.|:.:|   ...|||...|  :|.::|              |......|...
Zfish   111 RGPANPPGNDGIHEQSVLPVPTSHSGPAALGGNLSPQMSG--------------GFDEKSSPMAV 161

  Fly   190 AGQLGSKGEKGEPAKENGDYAKGEKGEPGWRGTAGLAGPQGFPGEKGERGDSGPYGAKGPRGEHG 254
            .|.:|..|.:|.|            |.||..|..|..||.|.|||.|..|..||.||.||.|::|
Zfish   162 PGPMGPMGPRGAP------------GPPGPSGPQGFTGPPGEPGEAGAPGPMGPRGAAGPPGKNG 214

  Fly   255 LKGEKGASCYGPMKPGAPGIKGEKGEPASSFPVKPTHTVMGPRGDMGQKGEPGLVGRKGEPGPEG 319
            ..||.|       |||.|   ||:|.|             ||:|..|..|.|||.|.||.   .|
Zfish   215 EDGESG-------KPGRP---GERGPP-------------GPQGARGFPGTPGLPGIKGH---RG 253

  Fly   320 DTGLDGQKGEKGLPGGPGDRGRQGNFGPPGSTGQKGDRGEPGLNGLPGNPGQKGEPGRAGATGKP 384
            .:||||.||:.| |.||.        |.||:.|:.|..|..|..||||..|:.|.||.|||.|..
Zfish   254 FSGLDGAKGDAG-PAGPK--------GEPGAPGENGTPGAMGPRGLPGERGRAGPPGAAGARGND 309

  Fly   385 GLLGPPGPPGGGRGTPGPPGPKGPRGYVGAPGPQGLNGVDGLPGPQGYNGQKGGAGLPGRPGNEG 449
            |..|..||       |||.||.||.|:.|.||.:      |..||||..|.            ||
Zfish   310 GAAGAAGP-------PGPTGPAGPPGFPGGPGSK------GEVGPQGSRGA------------EG 349

  Fly   450 PPGKKGEKGTAGLNGPKGSIGPIGHPGPPGPEGQKGDAGLPGYGIQGSKGDAGIPGYPGLKGSKG 514
            |.|.:||   ||..||.|..||.|:.|..|..|.||..|.||.        ||.||:||.:|.
Zfish   350 PQGARGE---AGNPGPAGPAGPAGNNGADGAPGAKGAPGAPGI--------AGAPGFPGPRGP-- 401

  Fly   515 ERGFKGNAGAPGDSKLGRPGTPGAAGAPGQKGDAGRPGTPGQKGDMGIKGDVGGKCSSCRAGPKG 579
                              ||..|||||||.||:.|..|.||.||:.|.||:.|.:......||.|
Zfish   402 ------------------PGAAGAAGAPGPKGNTGEAGAPGAKGEAGAKGEAGAQGVQGPPGPPG 448

  Fly   580 DKGTSGLPGIPGKDGARGPPGERGYPGERGHDGINGQTGP---PGEKGEDGRTGLPGATGEPGKP 641
            ::|..|..|.||..|||||.||||.||.||..|.:|..||   |||:|..|..|..|||||||:
Zfish   449 EEGKRGPRGEPGAGGARGPTGERGAPGARGFPGADGAAGPRGAPGERGGPGVVGPKGATGEPGR- 512

  Fly   642 ALCDLSLIEPLKGDKGYPGAPGAKGVQGFKGAEGLPGIPGPKGEFGFKGEKGLSGAPGNDGTPGR 706
                          .|.||.||:||:      .|.||.|||      .|:.|..||||.||.||.
Zfish   513 --------------NGEPGMPGSKGM------TGSPGSPGP------DGKTGPGGAPGQDGRPGP 551

  Fly   707 AGRDGYPGIPGQSIKGEPGFHGRDGAKGDKGSFGRSGEKGEPGSCALDEIKMPAKGNKGEPGQTG 771
            .|..|        .:|:||..|..|.||                         |.|..|:||:.|
Zfish   552 PGPVG--------ARGQPGVMGFPGPKG-------------------------AAGEAGKPGERG 583

  Fly   772 MPGPPGEDGSPGERGYTGLKGNTGPQGPPGVEGPRGLNGPRGEKGNQGAVGVPGNPGKDGLRGIP 836
            :.|..|..|:||:.|..|..|..||.||.|..|.:|..||.|.:|..|..|..|.|||.|.:|.|
Zfish   584 VMGAIGATGAPGKDGDVGAPGAPGPAGPAGERGEQGAAGPPGFQGLPGPQGATGEPGKSGEQGAP 648

  Fly   837 GRNGQPGPRGEPGISRPGPMGPPGLNGLQGEKGDRGPTGPIGFPGADGSVGYPGDRGDAGLPGVS 901
            |..|.|||.|    ||       |..|..||:|..||.||:|..|:.||.|..|.:|::   |.:
Zfish   649 GEAGAPGPSG----SR-------GDRGFPGERGAPGPAGPVGARGSPGSAGNDGAKGES---GAA 699

  Fly   902 GRPGIVGEKGDVGPIGPAGVAGPPGVPGIDGVRGRDGAKGEPGSPGLVGMPGNKGDRGAPGNDGP 966
            |.|               |..||||:.|:            ||..|..|:||.|||||..|..|.
Zfish   700 GAP---------------GAQGPPGLQGM------------PGERGAAGLPGLKGDRGDQGAKGA 737

  Fly   967 KGFAGVTGAPGKRGPAGIPGVSGAKGDKGATGLTGNDGPVGGRGPPGAPGLMGIKGDQGLAGAPG 1031
            .|.||..|..|..||.|.||.:||.||||.:|..|..||.|.|||||..|..|..|..|.||.|
Zfish   738 DGAAGKDGIRGMTGPIGPPGPAGAPGDKGESGAQGLVGPTGARGPPGERGETGAPGPAGFAGPP- 801

  Fly  1032 QQGLDGMPGEKGNQGFPGLDGPPGLPGDASEKGQKGEPGPSGLRGDTGPAGTPGWPGEKGLPGLA 1096
              |.||:||.||..|..|..|..|.||.|...|..|..||.|..|..|..|..|.||..|.||.|
Zfish   802 --GADGLPGAKGEPGDNGAKGDAGAPGPAGATGAPGPQGPVGATGPKGARGAAGPPGATGFPGAA 864

  Fly  1097 VHGRAGPPGEKGDQGRSGIDGRDGINGEKGEQGLQGVWGQPGEKGSVGAPGIPGAPGMDGLPGAA 1161
              ||.||||..|:.|..|..|..|..|:||.:|..|..|:.||   |||.|.|||||..|.|||.
Zfish   865 --GRVGPPGPSGNSGPPGPPGPAGKEGQKGNRGETGPAGRTGE---VGAAGPPGAPGEKGNPGAE 924

  Fly  1162 GAPGAVGYPGDRGDKGEPGLSGLPGLKGETGPVGLQGFTGAPGPKGERGIRGQPGLPATVPDIRG 1226
            ||.|..|.||.:|..|:.|:.||||.:||      :||.|.|||.||
Zfish   925 GATGPAGIPGPQGIGGQRGIVGLPGQRGE------RGFPGLPGPSGE------------------ 965

  Fly  1227 DKGSQGERGYTGEKGEQGERGLTGPAGVAGAKGDRGLQGPPGASGLNGIPGAKGDIGPRGEIGYP 1291
                .|::|.:|..||:|..|..||.|:||..|:.|.:|.||..|..|..||.|..|.|||
Zfish   966 ----IGKQGPSGPSGERGPPGPMGPPGLAGPPGEPGREGTPGNEGSAGRDGAAGPKGDRGE---- 1022

  Fly  1292 GVTIKGEKGLPGRPGRNGRQGLIGAPGLIGERGLPGLAGEPGLVGLPGPIGPAGSKGERGLAGSP 1356
                .|..|.||.||.                  ||.|         |||||||..|:||..|..
Zfish  1023 ----TGPSGTPGAPGP------------------PGAA---------GPIGPAGKTGDRGETGPA 1056

  Fly  1357 GQPGQDGFPGAPGLKGDTGPQGFKGERGLNGFEGQKGDKGDRGLQGPSGLPGLVGQKGDTGYPGL 1421
            |.||..| |..|  :|.:||.|.:|::|..|..|::|.||.||..|..|.|         |.||.
Zfish  1057 GVPGPAG-PSGP--RGPSGPAGARGDKGETGEAGERGMKGHRGFTGMPGPP---------GPPGP 1109

  Fly  1422 NGNDGPVGAPGERGFTGPKGRDGRDGTPGLPGQKGEPGMLPPPGPKGEPGQPGRNGPKGEPGRPG 1486
            :|..||.||.|.   .||:|..|..|:.|..|..|.||.:.||||:|..|:.|..||.|.||.|
Zfish  1110 SGESGPAGASGP---AGPRGPAGSAGSAGKDGMSGLPGPIGPPGPRGRNGEIGPAGPPGPPGPP- 1170

  Fly  1487 ERGLIGIQGERGEKGERGLIGETGNVGRPGPKGDRGEPGERGYEGAIGLIGQKGEPGAPAPAALD 1551
                                      |.|||.|.       |::  ||.|.|..|. ||.|
Zfish  1171 --------------------------GAPGPSGG-------GFD--IGFIAQPQEK-APDP---- 1195

  Fly  1552 YLTGILITRHSQSETVPACSAGHTELWTGY--------SLLYVDG---NDYAHNQDLGSPGSCVP 1605
                   .||.:::..........|:.|..        |::..||   |.....:||   ..|.|
Zfish  1196 -------FRHFRADDANVMRDRDLEVDTTLKSLSQQIESIISPDGTKKNPARTCRDL---KMCHP 1250

  Fly  1606 RFST-----LPVLSCGQNNV---CN--------------------YASRNDK------------- 1629
            .:.:     .|...|.|:.:   ||                    |.|:|.|
Zfish  1251 DWKSGEYWIDPDQGCNQDAIKVYCNMETGETCVNPTESAIPKKNWYTSKNIKEKKHVWFGEAMTD 1315

  Fly  1630 --TFWLTTNAAIPMMPVENIEIRQYISRCVVCEAPANVIAVHSQTIEVPDCPNGWEGLWIGYSFL 1692
              .|...:..:.|    |::.|:....|.:..||..| |..|        |.|.     |.|
Zfish  1316 GFQFEYGSEGSKP----EDVNIQLTFLRLMSTEASQN-ITYH--------CKNS-----IAY--- 1359

  Fly  1693 MHTAVGNGGGGQALQSPGSCLEDFRATPFIECNGAKGTCHFYETMT 1738
            |..|.||  ..:||...||...:.|         |:|...|..::|
Zfish  1360 MDQASGN--LKKALLLQGSNEIEIR---------AEGNSRFTYSVT 1394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Col4a1	NP_723044.1	Collagen	104..161	CDD:189968	19/61 (31%)
		Collagen	322..380	CDD:189968	26/57 (46%)
		Collagen	413..465	CDD:189968	17/51 (33%)
		Collagen	499..561	CDD:189968	24/61 (39%)
		Collagen	574..632	CDD:189968	31/60 (52%)
		Collagen	657..714	CDD:189968	25/56 (45%)
		Collagen	765..824	CDD:189968	25/58 (43%)
		Collagen	854..911	CDD:189968	19/56 (34%)
		Collagen	884..943	CDD:189968	14/58 (24%)
		Collagen	923..982	CDD:189968	24/58 (41%)
		Collagen	1028..1085	CDD:189968	24/56 (43%)
		Collagen	1229..1287	CDD:189968	24/57 (42%)
		Collagen	1318..1376	CDD:189968	21/57 (37%)
		Collagen	1399..1458	CDD:189968	21/58 (36%)
		Collagen	1477..1534	CDD:189968	12/56 (21%)
		C4	1555..1662	CDD:128421	27/160 (17%)
		C4	1663..1777	CDD:128421	20/76 (26%)
col1a1a	NP_954684.1	VWC	33..88	CDD:278520	11/56 (20%)
		Collagen	190..247	CDD:189968	33/79 (42%)
		Collagen	220..279	CDD:189968	35/93 (38%)
		Collagen	454..523	CDD:189968	39/83 (47%)
		Collagen	508..579	CDD:189968	39/130 (30%)
		Collagen	628..687	CDD:189968	30/69 (43%)
		Collagen	778..836	CDD:189968	28/60 (47%)
		Collagen	823..875	CDD:189968	25/53 (47%)
		Collagen	<1047..1090	CDD:189968	18/45 (40%)
		COLFI	1213..1446	CDD:279718	46/217 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BAFZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900